Influence of progestin use on the IL-10 level in peritoneal endometriosis

Paula Medina Poeta Fermino; Lia Karina Volpato; Anna Paula Piovezan; Verônica Vargas Horewicz; Daniel Fernandes Martins; Rodrigo Dias Nunes

doi:10.53730/ijhs.v6nS1.7671

Authors

Paula Medina Poeta Fermino Postgraduate Program in Health Science - Universidade do Sul de Santa Catarina (UNISUL), Palhoça, Santa Catarina (SC), Brasil
Lia Karina Volpato
lia.volpato@unisul.br
Postgraduate Program in Health Science - Universidade do Sul de Santa Catarina (UNISUL), Palhoça, Santa Catarina (SC), Brasil & Hospital Regional Homero de Miranda Gomes, São José - SC, Brasil
Anna Paula Piovezan Postgraduate Program in Health Science - Universidade do Sul de Santa Catarina (UNISUL), Palhoça, Santa Catarina (SC), Brasil
Verônica Vargas Horewicz Postgraduate Program in Health Science - Universidade do Sul de Santa Catarina (UNISUL), Palhoça, Santa Catarina (SC), Brasil
Daniel Fernandes Martins Postgraduate Program in Health Science - Universidade do Sul de Santa Catarina (UNISUL), Palhoça, Santa Catarina (SC), Brasil
Rodrigo Dias Nunes Hospital Regional Homero de Miranda Gomes, São José - SC, Brasil

Keywords:

endometriosis, peritoneum, cytokines, IL-10, progestin

Abstract

Purpose: How can progestin influence the anti-inflammatory cytokine IL-10 level in the peritoneum with endometriosis? Methods: A cross-sectional study with a laboratory analysis carried out in tertiary hospitals in southern Brazil with clinical-demographic data compilation and sample collection of peritoneal lavage and a peritoneum biopsy from 40 patients — 22 with endometriosis (11 with progestin and 11 without it) and 18 in the control group — was conducted. For the sample analysis, the ELISA was performed, and a comparison of the average IL-10 concentrations by ANOVA followed by Bonferroni was carried out. Results: There was a higher concentration of IL-10 among patients with endometriosis compared to the control group (p ≤ 0.05), and statistical significance was observed with a reduction of IL-10 in the peritoneal lavage of patients with endometriosis in the use of progestin (8.1 ± 7.4 pg/ml) compared to those with endometriosis without using progestin (17.9 ± 10.5 pg/ml). Considering the disease stage, a higher level of IL-10 (p ≤ 0.05) was observed both in the initial stages (12.1 ± 10.5 pg/ml) and in advanced stages (15.4 ± 9.7 pg/ml) compared to the control (1.7 ± 1.8 pg/ml), which was significantly higher for advanced endometriosis.

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