Comparison of the interleukin-33 among the healthy and aggressive periodontitis cases: An original research

Fozia Sultana; Annavarapu Sahithi; Anas Abdul Khader; Yella Ramya; Kommuri Kavya Reddy; A Kiranamye

doi:10.53730/ijhs.v6nS1.7682

Authors

Fozia Sultana
fozia.freedom@gmail.com
Senior lecturer, Department of periodontics and Implantology, Himachal institute of dental sciences, Paonta sahib, H.P.
Annavarapu Sahithi Consultant Periodontist, Chief Faculty, Zeus Terra Dental Accademy.
Anas Abdul Khader Assistant Professor, Department of Preventive Dentistry, College of Dentistry in ArRass, Qassim University, Kingdom of Saudi Arabia
Yella Ramya Senior lecturer, Department of Periodontics and Oral Implantology, Care Dental College, Guntur, AP.
Kommuri Kavya Reddy Consultant Periodontics and Oral Implantology, Hyderabad, Telangana
A Kiranamye Consultant periodontist and implantologist, Visakhapatnam, Andhra Pradesh

Keywords:

Interleukin-33, Chronic Periodontitis, Aggressive Periodontitis

Abstract

Introduction: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection. Hence in this study we aim to compare the interleukin-3 among the healthy and aggressive periodontitis cases. Materials and Methods: We conducted a cross-sectional, biochemical, genetic study. We divided the groups to three as healthy group, chronic periodontitis patients, and generalized aggressive periodontitis patients. IL-33 concentration in GCF, as well as plasma, was quantified. Results: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33. Conclusions: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with generalized aggressive periodontitis.

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