Comparison of the interleukin-33 among the healthy and aggressive periodontitis cases
An original research
Keywords:
Interleukin-33, Chronic Periodontitis, Aggressive PeriodontitisAbstract
Introduction: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection. Hence in this study we aim to compare the interleukin-3 among the healthy and aggressive periodontitis cases. Materials and Methods: We conducted a cross-sectional, biochemical, genetic study. We divided the groups to three as healthy group, chronic periodontitis patients, and generalized aggressive periodontitis patients. IL-33 concentration in GCF, as well as plasma, was quantified. Results: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33. Conclusions: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with generalized aggressive periodontitis.
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