Clindamycin phosphate, tretinoin with benzoyl peroxide versus clindamycin phosphate and tretinoin combination without benzoyl peroxide for the treatment of acne vulgaris: A comparative study

P. A. Anitha; M. Vara Prasanna Rao

doi:10.53730/ijhs.v6nS3.7739

Authors

Anitha P. A. Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advance Studies, Pallavaram, Chennai, India
M. Vara Prasanna Rao
mvprasanna90.sps@velsuniv.ac.in
Assistant Professor, Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advance Studies, Pallavaram, Chennai, India

Keywords:

clindamycin phosphate, tretinoin, benzoyl peroxide, acne topical preparations, acne antimicrobial treatment

Abstract

Introduction: Acne vulgaris (AV) is a prevalent skin disorder among adolescents. Affects around 80–90% of adolescents in the Western population. The present study aimed to compare the therapeutic efficacy of Clindamycin phosphate (CLM), Tretinoin (TN) with Benzoyl peroxide (BP) versus clindamycin phosphate and tretinoin combination without Benzoyl peroxide for treatment of AV. Methodology: 250 patients with mild to moderate acne on the face were enrolled in the study and were divided into two groups; group I (n=125); apply CLM 1.2%, TN 0.025%gel with BP 3.75% gel and group II (n=125) apply only CLM 1.2% and TN 0.025% gel without BP 3.75% gel; once daily at night for 4 weeks. The change in acne lesions was recorded every 2 weekly follow-ups using the global acne grading system and non-inflammatory (NI-L), Inflammatory (I-L) lesions count and Investigator's Static Global Assessment grading. Results: The research involved 250 patients split into two groups: 125 patients in group I and 125 patients in group II. After 4 weeks, the group I had a higher mean percent decrease in non-inflammatory, inflammatory, and total lesion count than group II.

Downloads

Download data is not yet available.

References

Simpson NB, Cunliffe WJ. Disorders of the Sebaceous glands. In: Burns T, Breathnach S, Cox N, Griffiths C editors. Rook's Textbook of Dermatology; 7th edition. Oxford: Black well scientific Publication; 2004; 43:15-42. https://iosrjournals.org/iosr-jdms/pages/19(6)Series-9.htm

Kubba R, Bajaj AK, Thappa DM, Sharma R, Vedamurthy M, Dhar S, et al . acne in india: Guidelines for management: Pathogenesis of acne. Indian J Dermatol Venereol Leprol 2009a; 75(1):S5-9. https://ijdvl.com/pathogenesis-of-acne/

The Evaluator's Global Severity Score (proposed at the Division of Dermatology Advisory Committee [DODAC] meeting of November 4 and 5, 2002). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140902/

Zaenglein AL, Graber EM, Thiboutot DM, Strauss JS. Acne Vulgaris and Acneiform Eruptions. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ editors. Fitzpatrick's Dermatology in General Medicine; 7th edition. New York: McGraw-Hill; 2008.P.690-703. https://accessmedicine.mhmedical.com/content.aspx?bookid=392&Sectionid=41138785

Piskin S, Uzunali E . A review of the use of adapalene for thetreatment of acne vulgaris. PubMed Central: Ther Clin Risk Manag 2007; 3(4):621-4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374937/

Abdel-Naser MB, Zouboulis CC. Clindamycin phosphate/ tretinoin gel formulation in the treatment of acne vulgaris. Expert Opin Pharmacother. 2008;9(16):2931–2937. https://europepmc.org/article/MED/15991883

Leyden JJ. A review of the use of combination therapies for the treatment of acne vulgaris. J Am Acad Dermatol. 2003;49(3):S200–S210. https://pubmed.ncbi.nlm.nih.gov/12963896/

Jarratt MT, Brundage T. Efficacy and safety of clindamycintretinoin gel versus clindamycin or tretinoin alone in acne vulgaris: a randomized, double-blind, vehicle-controlled study. J Drugs Dermatol. 2012;11(3):318–326. https://pubmed.ncbi.nlm.nih.gov/22395582/

Leyden JJ, Krochmal L, Yaroshinsky A. Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris. J Am Acad Dermatol. 2006;54(1):73–81. https://pubmed.ncbi.n/lm.nih.gov/16384759

Dogra S, Sumathy TK, Nayak C (2021) Efficacy and safety comparison of combination of 0.04% tretinoin microspheres plus 1% clindamycin versus their monotherapy in patients with acne vulgaris: a phase 3, randomized, double-blind study, Journal of Dermatological Treatment. 2021; 32(8): 925-33https://pubmed.ncbi.nlm.nih.gov/32020824/

Adityan B, Kumari R, Thappa DM. Scoring systems in acne vulgaris. Indian J Dermatol Venereol Leprol 2009;75:323-326. https://ijdvl.com/scoring-systems-in-acne-vulgaris/

White GM. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol 1998:39(2):S34-7. https://pubmed.ncbi.nlm.nih.gov/9703121/7

Bowman S, Gold M, Nasir A. Comparison of clindamycin/benzoyl peroxide, tretinoin plus clindamycin, and the combination of clindamycin/benzoyl peroxide and tretinoin plus clindamycin in the treatment of acne vulgaris: a randomized, blinded study. J Drugs Dermatol. 2005;4(5):611-8. https://pubmed.ncbi.nlm.nih.gov/16167420/

Bowman S, Gold M, Nasir A, Vamvakias G. Comparison of clindamycin/benzoyl peroxide, tretinoin plus clindamycin, and the combination of clindamycin/benzoyl peroxide and tretinoin plus clindamycin in the treatment of acne vulgaris: a randomized, blinded study. J Drugs Dermatol 2005;4(5):611-8. https://pubmed.ncbi.nlm.nih.gov/16167420/

Draelos ZD, Potts A, Alió Saenz AB. Randomized tolerability analysis of clindamycin phosphate 1.2%-tretinoin 0.025% gel used with benzoyl peroxide wash 4% for acne vulgaris. Cutis. 2010;86(6):310-8. https://pubmed.ncbi.nlm.nih.gov/21284283/

Aschoff R, Möller S, Haase R. Tolerability and Efficacy of Clindamycin/Tretinoin versus Adapalene/Benzoyl Peroxide in the Treatment of Acne Vulgaris. J Drugs Dermatol. 2021;20(3):295-301. https://pubmed.ncbi.nlm.nih.gov/33683070/