Vitamin D status in children with Cerebral palsy
A tertiary care center study
Keywords:
Vit. D, antiepileptic drug, Cerebral palsyAbstract
Background: Cerebral palsy(CP) is presently defined as a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. Low vitamin D levels in children with CP are also associated with decreased muscle strength, balance, muscle pain, paresthesias, and poor muscular coordination. Materials & Method: It is the Prospective observational cross-sectional study. The patients in the study group were of both sexes and aged 6 months to 12 years. All children apart from general tests underwent investigations for serum calcium total {By an automated analyzer}, serum phosphorus {By an automated analyzer}, serum alkaline phosphatase (SAP) levels {By an automated analyzer} and 25 OH vitamin D level {By CLIA (chemi luminescence immunoassay) method}. Results: Total 141 Children who satisfied inclusion and exclusion. Male children were 96 (68%) whereas female were 45(32%).The distribution by the CP type was Quadriplegia 44.0%, Diplegia 34.8%, Hemiplegia 7.1%, Monoplegia 1.4%, Hypotonic 2.1%, Dyskinetic 0.7%, Mixed 0.7%, Evolving CP 9.2%. Ambulatory CP children were 60 (42.5%) and non ambulatory were 81 (57.5%).
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Jones MW, Morgan E, Shelton JE, Thorogood C. Cerebral palsy: introduction and diagnosis (part I). J Pediatr Health Care. 2007 May-Jun;21(3):146-52.
Maclennan, A.H.; Lewis, S.; Moreno-De-Luca, A.; Fahey, M.; Leventer, R.J.; McIntyre, S.; Ben-Pazi, H.; Corbett, M.; Wang, X.; Baynam, G.; et al. Genetic or other causation should not change the clinical diagnosis of cerebral palsy. J. Child. Neurol. 2019, 34, 472–476.
Rosenbaum, P, Paneth, N, Leviton, A. A report: the definition and classification of cerebral palsy. Dev Med Child Neurol. 2007;109:8–14.
Maddock J, Zhou A, Cavadino A, et al.: Vitamin D and cognitive function: a Mendelian randomisation study. Scientific Reports. 2017, 10.1038/s41598-017-13189-3
Stanley, F, Blair, E, Alberman, E. Cerebral palsies: epidemiology & causal pathways. In: Clinics in Developmental Medicine. Cambridge, UK: Cambridge University Press; 2000:151.
Palisano R, Rosenbaum P, Walter S, et al.: Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol, 1997, 39: 214–223.
Russell DJ, Avery LM, Rosenbaum PL, Raina PS, Walter SD, Palisano RJ. Improved scaling of the gross motor function measure for children with cerebral palsy: evidence of reliability and validity. Phys Ther 2000; 80: 873-85.
McCormick A, Brien M, Plourde J, Wood E, Rosenbaum P, McLean J. Stability of the Gross Motor Function Classification System in adults with cerebral palsy. Dev Med Child Neurol 2007; 49: 265–69.
Fatima Ibrahim Al-Yatama, Fatemah Alotaibi, Maie Dawoud Al-Bader, Kamal A. Al-Shoumer, "The Effect of Clothing on Vitamin D Status, Bone Turnover Markers, and Bone Mineral Density in Young Kuwaiti Females", International Journal of Endocrinology, 2019. 1-10.
Peterson MD, Haapala HJ, Chaddha A, Hurvitz EA. Abdominal obesity is an independent predictor of serum 25-hydroxy vitamin D deficiency in adults with cerebral palsy. Nutr Metab (Lond) 2014; 11: 22.
Anderson JL, May HT, Horne BD, Bair TL, Hall NL, Carlquist JF, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol 2010; 106: 963–8.
Akpinar P. Vitamin D status of children with cerebral palsy: Should vitamin D levels be checked in children with cerebral palsy? North Clin Istanb. 2018 Aug 8;5(4):341-347.
Fishman LN, Bousvaros A. Gastrointestinal issues in the child with cerebral palsy. Int Pedia Gastroenterol Nutrition. 1999;8:1-9.
Anju Seth, Satinder Aneja, Ritu Singh, Ritu Majumdar, Neera Sharma & Muthuselvan Gopinath. Effect of impaired ambulation and anti-epileptic drug intake on vitamin D status of children with cerebral palsy, Paediatrics and International Child Health 2017, 37:3, 193-198
Toopchizadeh V, Barzegar M, Masoumi SH, Jahanjoo F. Prevalence of Vitamin D Deficiency and Associated Risk Factors in Cerebral Palsy, A study in North-West of Iran: A Case-Control Study. Iran J Child Neurol.Spring 2018; 12(2):25-32
Laisram N, Goyal V, Bhatnagar S, Muzaffar T, Changing trends in clinical Profile of cerebral palsy. IJPMR. 2016;27(1):10-3.
Singhi P, Saini A.G. Changes in the clinical spectrum of cerebral palsy over two decades in North India- an analysis of 1212 cases. J Trop Pediatr. 2013;59(6):434-40.
Kumar R, Gupta AK, Runu R, Pandey SK, Kumar M. Clinical profile of cerebral palsy: a study from multidisciplinary clinic at tertiary care centre. Int J Contemp Pediatr 2018;5:1626-30.
Manohar S et al.Vitamin D status in children with cerebral palsy. International Journal of Contemporary Pediatrics. Int J Contemp Pediatr. 2017 Mar;4(2):615-619
Harinarayan CV, Ramalakshmi T, Prasad UV, Sudhakar D. Vitamin D status in Andhra Pradesh: a population based study. Indian J Med Res. 2008;127:211-8.
Marwaha RK, Tandon N, Reddy DHK, Aggarwal R, Singh R, Sawhney RC, et al. Vitamin D and bone mineral density status of healthy school children in northern India. Am J Clin Nutr. 2005;82:477-82.
Hendersonn AC. Vitamin D levels in non-institutionalized children with cerebral palsy. J Child Neurol. 1997;12(7):443-7.
Sahota O. Understanding vitamin D deficiency. Age Ageing 2014;43:589-91.
Min et al. Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies BMC Pediatrics, 2020; 20:97.
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