Adverse effects of aspirin on hormonal and hastopathlogical changes in male rats
Keywords:
aspirin, hormonal, hastopathlogical, male ratsAbstract
Aspirin (Acetylsalicylic acid) is widely used in human and veterinary as anti-inflammatory cardiovascular prophylaxis, anti-clotting agent and to decrease cancer risk. However, it is frequently mis- or over-consumed to prevent pain . Many hazards linked with its use have been recorded, but there is a lack of data on its effects on androgenic studies, testicular histology, kidney histology, liver histology, and reproductions.
We tried to gather information on its adverse toxicity effects on male rat reproductive in this research. According to research, aspirin has a fatal effect on sperm production and reproductive hormones, as well as lowering testicular weight and altering blood profile. Because aspirin is a prostaglandin inhibitor, it may have an effect on the male reproductive system. Aspirin's detrimental toxic character is further revealed by liver damage.
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SedeeqBI, Sarhat ER , Wadee SA, Sarhat TR , Abass KS.Effects of Indomethacin Administration on Some Biochemical and Brain Histological Changes in Male Rats. Indian Journal of Forensic Medicine & Toxicology.2021;15( 3): 2127-2135.
Entedhar Rifaat Sarhat, Siham Ajmee Wadee, Ban Ismael Sedeeq, Thuraia Rifaat Sarhat, , Kasim Sakran Abass. Biochemical and Histological Evaluation of Indomethacin-induced Hepatotoxicity in Rats. P J M H S,2021; 15(4): 1038-1043.
Wu K. Aspirin and salicylate. Circulation. 2000;102:2022-2023.
Entedhar Rifaat Sarhat, Siham Ajmee Wadee, Ban Ismael Sedeeq, Thuraia Rifaat Sarhat, , Kasim Sakran Abass. Biochemical and Histological Evaluation of Indomethacin-induced Hepatotoxicity in Rats. P J M H S,2021; 15(4): 1038-1043.
Salim J.Khalaf, adeer Hatem Aljader, Entedhar R. Sarhat et al. Antidiabetic effect of Aqueous Extract of Medicago Sativa withEnhanced Histopathology of Pancreas in Alloxan Induced DiabeticRats. P J M H S.2021;15( 2);:492-496.
Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, et al. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature. ENGLAND; 1996 Dec;384(6610):644-648.
Alvarez-Larran A, Pereira A, Guglielmelli P, Hernandez- Boluda JC, Arellano-Rodrigo E, Ferrer-Marin F, et al. Antiplatelet therapy versus observation in low-risk essential thrombocythemia with CALR mutation. Haematologica. 2016 May;8.
Klessig DF, Tian M, Choi HW. Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals. Front Immunol. Switzerland; 2016;7:206.
Ibtisham F, Yangfen N, Wang Z, Wu J, Xiao M, An L. Animal Cloning Drawbacks An-Overview. J Dairy Vet AnimRes [Internet]. 2016;3(4):3-7.
Khalid G. Washeel, Entedhar R. Sarhat, Talal H. Jabir. Assessment of melatonin and oxidant-antioxidant markers in infertile men in Thi-Qar Province. Indian Journal of Forensic Medicine & Toxicology, .2019.13( 4) . 1495- 1499.
Roodbari F, Abedi N, Talebi AR. Early and late effects of Ibuprofen on mouse sperm parameters, chromatin condensation, and DNA integrity in mice. Iran J Reprod Med [Internet]. Yazd, Iran: Research and Clinical Center for Infertility; 2015 Nov 29;13(11):703-710.
Ahmadi R, Ahmadifar M, Safarpour E, Vahidi-Eyrisofla N, Darab M, Eini AM, et al. The Effects of Levofloxacin on Testis Tissue and Spermatogenesis in Rat. Cell J. Iran; 2016;18(1):112-116.
Lara NLM, Santos IC, Costa GMJ, Cordeiro-Junior DA, Almeida ACG, Madureira AP, et al. Duration of spermatogenesis and daily sperm production in the rodent Proechimys guyannensis. Zygote. 2016 Jun;1-11.
Hasanin NA, Sayed NM, Ghoneim FM, Al-Sherief SA. Histological and Ultrastructure Study of the Testes of Acrylamide Exposed Adult Male Albino Rat and Evaluation of the Possible Protective Effect of Vitamin E Intake. J Microsc Ultrastruct. 2018;6(1):23-34. doi:10.4103/JMAU.JMAU_7_18
Entedhar Rifaat Sarhat, Siham A. Wadi, B.I. Sedeeq, Th.R. Sarhat and N.A. Jasim.Study of histopathological and biochemical effect of Punica granatum L. extract on streptozotocin -induced diabetes in rabbits .Iraqi Journal of Veterinary Sciences,2019. 33( 1):189-194.
Entedhar Rifaat Sarhat, Siham A. Wadi, Ayhan R. Mahmood .Effect of Ethanolic Extraction of Moringa oleifera on Paraoxonase and Arylesterase enzyme activity in High Fat Diet-induced Obesity in Rats. Research J. Pharm. and Tech.2018; 11(10): 4601- 4604
Didolkar AK, Gurjar A, Joshi UM, Sheth AR, Roychowdhury D. Effects of aspirin on blood plasma levels of testosterone, LH and FSH in maturing male rats. Int J Androl. DENMARK; 1980 Jun;3(3):312-318.
Mazaud-Guittot S, Nicolaz CN, Desdoits-Lethimonier C, Coiffec I, Maamar M Ben, Balaguer P, et al. Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent. J Clin Endocrinol Metab. 2013;98(11):1757-1767.
Lyon MF, Glenister PH, Lamoreux ML. Normal spermatozoa from androgen-resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis. Nature. ENGLAND; 1975 Dec;258(5536):620-622.
. O’Shaughnessy PJ, Morris ID, Huhtaniemi I, Baker PJ, Abel MH. Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice. Mol Cell Endocrinol. Ireland; 2009 Jul;306(1-2):2-8.
El-Sharaky AS, Newairy AA, Elguindy NM, Elwafa AA. Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats. Food Chem Toxicol [Internet]. 2010 Dec;48(12):3354-3361.
De Gendt K, Swinnen J V, Saunders PTK, Schoonjans L, Dewerchin M, Devos A, et al. A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A. United States; 2004 Feb;101(5):1327-132.
Meng J, Holdcraft RW, Shima JE, Griswold MD, Braun RE. Androgens regulate the permeability of the blood-testis barrier. Proc Natl Acad Sci U S A. United States; 2005 Nov;102(46):16696-16700.
Al-Rubaee, E. A. (2005). Effect of Alcoholic Extract of Fenugreek Seeds on Fertility in Albino Male Mice. MSc Thesis, University of Baghdad, College of Science for Women, University of Baghdad.
Yen-s, S. C.; Jaffe, R. B. and Barbieri, R. L. (1999). Reproductive endocrinology. Physiology, pathophysiology and clinical management. 4th Ed. W.B. Saunders Company. Biol. Reprod., 54: 1347–55.
Elftman H. Sertoli cells and testis structure. Am J Anat [Internet]. Wiley Subscription Services, Inc., A Wiley Company; 1963;113(1):25-33. Available from: http://dx.doi.org/10.1002/aja.1001130104.
Asok Kumar R, Chinoy NJ. Effects of acetylsalicylic acid on reproductive organs of adolescent male rats. Endocrinol Exp. CZECHOSLOVAKIA; 1988 Sep;22(3):187-195.
Hai Y, Hou J, Liu Y, Liu Y, Yang H, Li Z, et al. The roles and regulation of Sertoli cells in fate determinations of spermatogonial stem cells and spermatogenesis. Semin Cell Dev Biol [Internet]. Elsevier Ltd; 2014;29:66-75.Availablefrom: http://dx.doi.org/10.1016/j.semcdb.2014.04.007.
Rebourcet D, Wu J, Cruickshanks L, Smith SE, Milne L, Fernando A, et al. Sertoli cells modulate testicular vascular network development, structure and function to influence circulating testosterone concentrations in adult male mice. Endocrinology. 2016 May;en20161156.
Marettova E, Maretta M, Legath J. Toxic effects of cadmium on testis of birds and mammals: a review. Anim Reprod Sci. Netherlands; 2015 Apr;155:1-10.
Li N, Mruk DD, Lee WM, Wong CKC, Cheng CY. Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis? Semin Cell Dev Biol [Internet]. Elsevier Ltd; 2015;1-16. Available from:http://dx.doi.org/10.1016/j.semcdb.2016.01.003
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