A review on properties of stem cells
Keywords:
Antibodies, Mesenchymal Stem Cells, Multipotent, ProgenitorsAbstract
Stem cells are multipotent progenitors constituting a small proportion of the bone marrow and are present in both adult and fetal tissues including adipose tissue, umbilical cord blood, amniotic fluid, and fetal lung. They were first characterized by Friedenstein and colleagues more than 30 years ago and were described as fibroblast-like cells with the property of adhering to plastic when cultured. This property can be used to purify these cells and enables them to expand several-fold in vitro without losing their differentiation capacity. They can differentiate into both mesenchymal and non-mesenchymal cell lineages such as adipocytes, osteoblasts, chondrocytes, tenocytes, skeletal myocytes, neurons, and cells of the visceral mesoderm, both in vitro and in vivo.
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