Phytochemical screening, isolation and characterization of potential bioconstituents present in hyptis suaveolens
Keywords:
hyptis suaveolens, suaveolol, methyl suaveolate, bergatonolAbstract
The phytoconstituents derived from the indigenous and traditional used plants are the indispensable source for many diseases. In the present scenario especially post Covid 19, many preferred the use of herbal constituent rather than using synesthetic medicines. The study aimed to identify the constituents derived from the leaves of Hyptis suaveolens Poit. (Lamiaceae) by separation and isolation of the three main compounds suaveolol, methyl suaveolate and bergatonol, which was achieved by means of repeated column chromatography and repeated preparative thin layer chromatography. Their chemical structures were characterised by IR, 1 H NMR, 13C NMR and LC-MS experiments.
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Sharma, P.P.; Roy, R.K.; Anurag, D.G.; Vipin, K.S. Hyptis suaveolens (L.) poit: A phyto-pharmacological review. Int. J. Chem. Pharm. Anal. 2013, 4, 1–11.
Adeolu, O.E., Adeleke, A.K., Giwa A.A.O., 2005. Chemical composition of essential oils of two Hyptis suaveolens (L.) Poit leaves from Nigeria. Flavour and Fragrance Journal 20, 528-530.
Ana Carolina Pessoa Moreira, Edeltrudes de Oliveira Lima ,Paulo Alves Wanderley, Egberto Santos Carmo and Evandro Leite de Souza . Chemical composition and antifungal activity of Hyptis suaveolens (L.) poit leaves essential oil against Aspergilllus species. Brazilian Journal of Microbiology (2010) 41: 28-33.
Ernest, T.J., Joseph, J., 1995. Chemical composition of essential oil in two ethnomedicinal species of Hyptis. Acta Pharmaceutica 45, 551-553.
Fun, C.E., Baerheim, A., Svendsen, A., 1990. The essential oil of Hyptis suaveolens Poit. Grown on Aruba West Indies. Flavour and Fragrance Journal 5 (3), 161-164.
Gowda, D.C., 1984. Poly Saccharide Components of the Seed Coat Mucilage from Hyptis suaveolens. Phytochemistry 23(2), 337-338.
Grassi, P., Urias-Reyes, T.S., Sosa, S., Tubaro, A., Hofer, O., Zitterl-Eglseer, K., 2006. Anti-inflammatory activity of two diterpenes of Hyptis suaveolens from El Salvador. Zeitschrift für Naturforschung C 61(4), 165-70.
Hameed, A., Annamalai, K., 2014. Pharmacognostical and Phytochemical Evaluation on Leaves of Three Different Geographical Races of Hyptis suaveolens (L).Poit, Lamiaceae. International Journal of Green and Herbal Chemistry 3 (2), 752-764.
Iwu, M.M., Ezeugwu, C.O., Okunji, C.O., Sanson, D.R. Tempesta, M.S., 1990. Antimicrobial activity and terpenoids of the essential oil of Hyptis suaveolens. International Journal of Crude Drug Research 28, 73-76.
Jayakumar, R.V and Nisha, B., 2005. Prevention of Diabetes Mellitus. Health Action 18(6), 19.
Jayakumar, S.V., Ganesh, S.M.K., 2012. New enolic type bioactive constituents from Hyptis suaveolens (L.) Poit. Asian Journal of Plant Science and Research 2 (4), 403-408.
Jayakumar, S.V.; Ganesh, S.K. New enolic type bioactive constituents from Hyptis suaveolens (L.) Poit. Asian J. Plant Sci. Res. 2012, 2, 403–408.
Joseph R.A., Pandiyarajan V.V., 2011. Petchimuthu K. Comparison of chemical composition of the essential oil of Hyptis suaveolens (l.) Poit leaves from different regions of Tamilnadu. International Journal of Pharmaceutical Sciences and Research 2(11), 2822-2824.
Joseph-McCarthy, D., 1999. Computational approaches to structure-based ligand design - a major success of structure-assisted drug design. Pharmacology therapies 84, 179–191.
Kundan Singh Bora & Anupam Sharma (2011) Phytochemical and pharmacological potential of Medicago sativa: A review, Pharmaceutical Biology, 49:2, 211-220.
Manchanda P.S., Fayos D.W.J., Clardy, J., 1974. Structures of Suaveolic Acid and Suaveolol. Journal of Organic Chemistry 39 (15), 2306-2308.
Manchanda, P., 2000. Heart Attack Causes and Prevention. Health Action, Indian Medical Gazette, 296-299.
Mary T.R., Anusha, K., Mallaiah K.V., Rabindranath K., Rao, M.C., 2014. Phytochemical Studies of Hyptis Suaveolens (L.) Poit. Journal of Chemical, Biological and Physical Sciences. 4, (1), 319-323
Misra T.N., Singh, R.S., Ojha, T.N., Upadhyay, J., 1981. Chemical constituents of Hyptis suaveolens spectral and biological studies on a tri-terpene acid. Journal of Natural Products 44, 735-738.
Misra, T.N., Singh, R.S., Upadhyay, J., 1983. A Natural Tri Terpene Acid From Hyptis suaveolens. Phytochemistry 22(11), 2557-2558.
Moreira A.C.P., Lima E.O., Souza P.W., Carmo E.S., Souza, E.L., 2010. Chemical composition and antifungal activity of Hyptis suaveolens (L.) Poit leaves essential oil against Aspergillus species. Brazilian Journal of Microbiology 41(1), 28-33.
Mukherjee, K.P., 2002. Quality control of herbal drugs. Business horizons. New Delhi, 2-14.
Mukherjee, K.S., Mukherjee, R.K., Ghosh, P.K., 1984. Chemistry of Hyptis suaveolens: a pentacyclic triterpene. Journal of Natural Products 47 (2), 377-378.
Nayak, S.; Kar, D.M. Evaluation of antidiabetic and antioxidant activity of aerial parts of Hyptis suaveolens Poit. Afr. J. Pharm. Pharmacol. 2013, 7, 1–7. [CrossRef]
Neucırio, R. Azevedo, Irani F.P. Campos, Heleno, D., Ferreira, Toma, ´ S.A., Portes Suzana, C., Santos, Jose C., Seraphin, Jose R., Paula, P., Ferri, H., 2001. Chemical variability in the essential oil of Hyptis suaveolens. Phytochemistry 57, 733–736.
Peerzada, N., 1997. Chemical Composition of the Essential Oil of Hyptis Suaveolens. Molecules 2, 165-168.
Ranaa V.S., Juyalb, J.P., Rashmic, Blazquezd, M.A., 2004. Volatile constituents of Hyptis suaveolens flowering twig oil. International Journal of Aromatherapy 14, 198–201.
Silva, A.F., Barbosa, L.C.A, Silva, E.A.M., Casali V.W.D., Nascimento, E.A., 2003. Chemical composition of the essential oil of Hyptis suaveolens (L.) Poit. (Lamiaceae). Revista Brasileira de Plantas Medicinais 6, 1-7
Subramanian, D.P., Venugopal, Sujatha., 2013. Antioxidant and cytotoxic studies on two known compounds isolated from Hyptis suaveolens leaves. International Journal of Pharmacy and Pharmaceutical Sciences 5(4), 283-290.
Tchoumbougnang, F., Zollo P.H.A., Boyom F.F., Nyegue M.A., Bessiere, J.M., Menut, C., 2005. Comparative study of the essential oils of four Hyptis species from Cameroon: H. lanceolata Poit., H. pectinata (L.) Poit., H. spicigera L and H. suaveolens Poit. Flavour and Fragrance Journal 20(3), 340-343.
Timsuksai, P., Suksamran, A., 2005. Chemical constituents of hyptis suaveolens (linn.) Poit. 31st Congress on Science and Technology of Thailand at Suranaree University of Technology 18- 20.
Tiwari, A.K., Rao, J.M., 2002. Diabetic mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects. Current Science 83(1), 30-38.
Chatterjee A and Pakrashi SC. “The Treatise on Indian Medicinal Plants”, Vol. 5, PID, New Delhi, 1997:15.
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