Surgical techniques and outcomes in patients with oral cavity cancer after induction chemotherapy

Mansour ELmoatasem; Omar Hamdy; Ziad Emarah; Waleed Elnahas; Sameh Roshdy; Khaled Abdelwahab

doi:10.53730/ijhs.v6nS1.8172

Authors

Mansour ELmoatasem Surgical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt.
Omar Hamdy
omarhamdy87@gmail.com
Surgical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt.
Ziad Emarah Medical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt.
Waleed Elnahas Surgical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt
Sameh Roshdy Surgical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt.
Khaled Abdelwahab Surgical Oncology Unit, Oncology Center, Mansoura University, Mansoura, Egypt.

Keywords:

Oral cancer, squamous cell carcinoma, tongue cancer, pathological complete response, survival

Abstract

Objective: Locally advanced Oral squamous cell carcinoma OSCC has a poor prognosis, surgery is mainline for treatment. The role of induction chemotherapy is still controversial. Methodology: This is a prospective study that included 25 patients with locally advanced OSCC who received induction chemotherapy with cisplatin, docetaxel & 5-FU (TPF) protocol regimen followed by surgical intervention. The epidemiological, surgical, and oncological outcomes of all the included patients were analyzed. Results: one patient showed no response, 18 patients had a partial response while 6 patients showed pathological complete response (pCR). Five out of the six patients who achieved pCR did not need reconstructive surgery and also five out of those 6 patients were operated on through a less destructive transoral approach. Consequently, those patients had less operative time, blood loss, hospital stay, and significantly less time to start oral feeding. The median disease-free survival was 15 (12-18) months in patients who attained pCR and 13 (5-24) months in the non pCR group. Conclusion: Pathological complete response after induction chemotherapy for locally advanced OSCC is associated with improvement in disease-free survival, less destructive surgery, and less need for flap reconstruction.

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