Effect of polarized light therapy versus low level laser therapy on oral mucositis in cancer patients receiving chemotherapy

Zakaria Mowafy Emam Mowafy; Hamed Abd Allah Hamed; Hany Mohamed Ibrahim Elgohary; Andrew Anis Fakhrey Mosaad

doi:10.53730/ijhs.v6nS1.8200

Authors

Zakaria Mowafy Emam Mowafy Physical therapy department for surgery, faculty of physical therapy, Cairo University, Egypt
Hamed Abd Allah Hamed Dermatology department, Faculty of Medicine, Cairo University, Egypt
Hany Mohamed Ibrahim Elgohary Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Delta University for Science and Technology.
Andrew Anis Fakhrey Mosaad Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Merit University

Keywords:

Bioptron light therapy, Low level laser therapy, Oral mucositis, WHO oral mucositis scale , Common toxicity criteria scale

Abstract

Purpose: to evaluate the efficacy of polarized light therapy versus low level laser therapy on oral mucositis in cancer patients receiving chemotherapy. Methods of evaluation (Measurement of the WHO oral mucositis scale and the Common toxicity criteria scale). Methods: Forty cancer patients receiving chemotherapy (Males and Females) who had oral mucositis, ulceration pain and their ages ranged from 30 to 55 years were divided into two groups. Group (A) composed of 20 patients received the low level laser therapy (LLLT) in addition to the routine medical care of oral mucositis Group (B) composed of 20 patients received Bioptron light therapy (BLT) in addition to the routine medical care of oral mucositis, duration of the BLT or LLLT application was 10 minutes applied daily for 30 days. Results and conclusion: Results showed that application of both the BLT and the LLLT had a valuable healing effect on oral mucositis in cancer patients receiving chemotherapy as evidenced by the highly decreases of the WHO oral mucositis scale and the Common toxicity criteria scale. But low level laser therapy (LLLT) was more beneficial than the Bioptron light therapy (BLT).

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References

Antonio LB, Pinheiro KH and Rodrigues FM, (2007): "Effects of Laser Therapy on Experimental Wound Healing Using Oxidized Regenerated Cellulose Hemostat" Photo-medicine and Laser Surgery 26(1): 10-13. doi:10.1089/pho.2115.

Asada KS, Yutani YA and Shimazu AP, (2007): Clinical application of Ga-Al-As 830 nm diode laser in treatment of rheumatoid arthritis. Laser Therapy; 3: 77-82.

Ballyzek MA, Vesovic VB and Johnston AA, (2005): Efficacy of polarized, polychromatic, non-coherent light in the treatment of chronic musculoskeletal neck and shoulder pain. St Petersburg Hospital, Russian Academy of Sciences, St Petersburg, Russia.

Barrick BP and Campbell EJ, (2009): “Leukocyte Proteinases in Wound Healing: Roles in Physiologic and Pathological Processes”. Wound Repair Regen, 7: Pp 410-422.

Baxter GD, (2004): Therapeutic Lasers: Theory and Practice. London, England: Churchill Livingstone; P. 27-41.

Baxter GH, Bell AH and Allen JJ, (2007): Low level laser therapy: current clinical practice in Northern Ireland. Physiotherapy.77:171–178.

Bentzen SM, Saunders MI and Dische SA, (2001): Radiotherapy-related early morbidity in head and neck cancer: quantitative clinical radiobiology as deduced from the CHART trial. Radiother Oncol. 2001; 60: 123–135.

Berardesca EF, Leveque JL and Masson PO, (2002): "EEMCO Guidance for measurement of skin microcirculation". Skin pharmacol APP skin physiol; 15:442-456.

Berg FD and Gunnarsson RL, (2008): "A method for measuring ulcer surface area". Lancet; 1445-1446.

Bjordal JM, Couppe CK and Chow RT, (2003): A systematic review of low level laser therapy with location –specific doses for pain from chronic joint disorders. Australian journal of physiotherapy; 49:107-116.

Blahnik JA and Rindge DW, (2003): Laser Therapy: A Clinical Manual. Melbourne, FL: Healing Light Seminars Inc.

Bolton PA, Young SH and Dyson MA, (2007): Macrophage responsiveness to laser therapy with varying power and energy densities. Laser Therapy.3:105–111.

Bolton PP and Young JJ, (2008): The effect of polarized light on the release of growth factors from the U-937 macrophage-like cell line. Laser Therapy; 2: 33-37.

Braams JW, Stegenga BA and Raghoebar GM, (2006): Treatment with soft laser, the effect on complaints after the removal of wisdom teeth in the mandible. Ned Tijdschr Tandheelkd.; 101(3):100-3.

Braun EV, Kasper DL and Jameson JL (2009): Principles of Wound Healing and laser. McGraw-Hill, chapter 4, pp. 1414-1425.

Brem HP, Kirsner RS, and Falanga VM, (2007):” Protocol for the successful treatment of skin ulcers.” The American Journal of Surgery, 188(1), P: 1-8.

Brown AT, Shupe AJ and Sims ER, (2006): In vitro effect of chlorhexidine and amikacin on oral gram negative bacilli from bone marrow transplant recipients. Oral Surg Oral Med Oral Pathol; 20:112-9.

Browse NL, Bernard KJ and Wilson N M, (2009): “Physiology and functional anatomy, Skin Diseases”. Oxford University Press, New York, PP. 49–65.

Bucalo BW, Eaglstein WH and Falanga VS, (2003): “Inhibition of Cell Proliferation by Chronic Wound Fluid”. Wound Repair Regen. 1: Pp 181-186.

Bulk BJ, (2006):"Skin ulcers Pathophysiology" Wound Repair Regen. 3: Pp 187-201.

Stanberry KB, Scanelli JA, and Vinik AI (2001). "Nitric oxide production mediates neurogenic vasodilatation in human skin but is not impaired in type 2 diabetes". Diabetes, 49, A33.

Stiff PJ, (2006): Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting. J Clin Oncol. 2006; 24: 5186–5193.

Stokman MA, Sonis ST and Dijkstra PV, (2005): Assessment of oral mucositis in clinical trials: impact of training on evaluations in a multi-centre trial. Eur J Cancer. 2005; 41: 1735–1738.

Trelles MA, Salas PG and Shirk TA, (2007): Infrared diode laser in low reactive-level laser (LLLT) for knee osteoarthrosis. Laser Therapy; 3: 149-153.

Trotti AB, Bellm LA and Epstein JB, (2003): Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol. 2003; 66: 253–262.

Tuner JA and Hode LG, (2002): Laser Therapy: Clinical Practice and Scientific Background. Gransgesberg, Sweden: Prima Books. P. 189- 96.

Vasiliev AF and Streltsova NJ, (2006): Low-level laser therapy in patients with ischaemic heart disease and possible mechanism of hypolipidaemic action.” Vopr Kurortol Fiz; 1:37–8.

Vera-Lynch MZ, Ester GC and Hagiwara AQ, (2006): Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer. 2006; 106: 329–336.

Wadleigh RG, Redman RS and Graham ML, (2009): Vitamin E in the treatment of chemotherapy induced mucositis. Am Med; 11:121- 9.

Walker GG and Vibeti Gk, (2004): "Pathophysiology of microvascular disease: In Chronic complication of DM. Pick up, Williams G (Eds). Blackwell Scientific Publications PP: 10-39.

Wang NA, Bytler JP and Ingher DE (2006): "Mechanotransduction across the cell surface and through the cytoskeleton, Science 260:1124.

Wayne PA, (2001):" Healing and Chronic Wound Management" 3rd ed. Health Management Publications, Pp 7-17.

Wilson FD and Pratten SQ, (2009): "Bacteria in supragingival plaque samples can be killed by low-power laser light in the presence of a photosensitizer. J Appl Bacteriol; 11; 323-331.

Wingard JR, Niehaus CS and Peterson DE, (2009): Oral mucositis after bone marrow transplantation: a marker of treatment toxicity and predictor of hepatic veno-occlusive disease. Oral Surg Oral Med Oral Pathol; 12: 210-26.

Woo SB, Sonis ST and Monopoli MM, (2008): A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients. Cancer; 11: 311-9.

Young MJ, (2000): "Classification of ulcers and its relevance to management. In Boulton AJ.M. Cavangh P.R., Connor H (Eds) the foot in diabetes.

Young SA, Bolton PD and Dyson MH, (2009): Macrophage responsiveness to light therapy. Lasers Surg Med.9:497–505.

Yurt RT, (2004): Role of the mast cell in trauma. In Dineen, Pan Hildick-Smith, G (eds): The Surgical Wound. Lea and Febiger, Philadelphia, p.37.

Zambezi PC, Machetes FM and Ceridian SH, (2009): "invasive surgical management of primary skin ulcers vs. laser treatment: a randomized clinical trial" Eur J Vasc Endovasc Surg.5: 313-8.

Zerbe MB, Parkerson SG and Ortlieb ML, (2012): Relationships between oral mucositis and treatment variables in bone marrow transplant patients. Cancer Nurs; 10:116-22.

Ziskin MC and Michel SL, (2005): "Bacteria, light and low level laser therapy. J Appl Bacteriol; 58; 467-501.