Association of ADH1C and ALDH2 genes with alcohol dependence in south Indian Tamilian population: A case control approach

Umamageswari Arunachalam; Aarthi Manoharan; Iyanar Kannan; Adithan Chandrasekaran

doi:10.53730/ijhs.v6nS3.8247

Authors

Umamageswari Arunachalam
leeuma6@gmail.com
Professor, Department of Pharmacology,T agore Medical College and Hospital, Rathinamangalam, Vandalur, Chennai, Tamilnadu, India. 600127
Aarthi Manoharan Research Scientist, Multidisciplinary Center for Biomedical Research, Vinayaka Mission’s Research Foundation, Aarupadai Veedu Medical College,Puducherry, India. 607402 ORCID iD: 0000-0003-2318-2786
Iyanar Kannan Associate Professor, Department of Microbiology, Tagore Medical College and Hospital, Rathinamangalam, Vandalur,Chennai, Tamilnadu, India. 600127
Adithan Chandrasekaran Former Dean Research, Sri Balaji Vidyapeeth, Pillaiyarkuppam, Puducherry, India. 607402

Keywords:

alcohol dependence, ADH1C polymorphism, ALDH2 polymorphism, genotyping, Tamilian population

Abstract

Objectives: Alcohol dependence (AD) poses a serious medical problem and significant public health issue contributing to morbidity and mortality throughout the world. The aim of the study was to establish the allele and genotype frequencies and to test the association of rs698 (ADH1C) and rs671(ALDH2) with the risk of alcohol dependence in south Indian Tamilian population. Methodology: A total of 150 alcohol dependent cases aged between 18- and 65-years fulfilling DSM-V criteria were recruited from the de-addiction centre. Blood donors (n=150) who had a history of alcohol intake with AUDIT score of less than eight were selected for the control group. The alleles were genotyped using TaqMan SNP genotyping assays by quantitative PCR. Association with alcohol dependence was evaluated with various genetic models using the Chi-square test. Multiple logistic regression analysis was performed to explore the effect of covariates. Results: The observed genotype frequency distributions of rs698 and rs671 were in agreement with Hardy Weinberg equilibrium (p>0.05).The dominant and allelic genetic model of ALDH2, rs671 between cases and controls showed a statistically significant association of the genetic variant with AD.

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