Evaluation of the renoprotective effects of metformin nanoparticles in rats with diabetic nephropathy

Khalid A. Edam; Mohsin E. Aldokheily; Firas F. Al-Yaseen

doi:10.53730/ijhs.v6nS1.8311

Authors

Khalid A. Edam
khal.abd.ch@sci.utq.edu.iq
Directorate of Education Thi-Qar, Ministry of Education, Iraq
Mohsin E. Aldokheily College of Science, University of Thi-Qar, Iraq
Firas F. Al-Yaseen College of Pharmacy, University of Thi-Qar, Iraq

Keywords:

Metformin Nanoparticles, Microemulsions, Diabetic Nephropathy, rats

Abstract

A system microemulsions was used to make metformin nanoparticles. Transmission electron microscope (TEM) and Scanning Electron Microscopy were used to diagnose previously prepared nanoparticles, which found that the average size of previously prepared nanoparticles is 29.5 nm. This study looked at the effects of metformin nanoparticles on rats with diabetic nephropathy. Diabetic nephropathy was successfully developed in rats using a high-fat diet and a single dose of 30 mg/kg streptozotocin. Metformin nanoparticles was administered intragastrically for 60 days, and fasting blood sugar, fasting insulin concentration, serum urea, serum albumin, serum creatinine, albuminuria and albumin to creatinine ratio were subsequently examined at the end of administration. The current investigation found that metformin NPs therapy effectively lowered fasting blood sugar, fasting insulin concentration, serum urea, serum albumin, serum creatinine, albuminuria, and albumin to creatinine ratio in diabetic nephropathy rats, with an increase in serum albumin.

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