Aspirin and celecoxib revealed anticancer and immunomodulatory effects on colon cancer cells

Rusul Kadhum; Majed K. Abbas; Kaiser N. Madlum

doi:10.53730/ijhs.v6nS1.8380

Authors

Rusul Kadhum Department of pharmacology and toxicology, College of Medicine, University of Babylon, Iraq
Majed K. Abbas Department of pharmacology and toxicology, College of Medicine, University of Babylon, Iraq
Kaiser N. Madlum
kaiser.madlum@uobabylon.edu.iq
Department of human anatomy, College of Medicine, University of Babylon, Iraq

Keywords:

SW 480, colon cancer, Asprin, celecoxib, NSAIDs, anti-inflammatory

Abstract

Colorectal cancer is one of the most common malignancies in the world. Clinical evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs ) were found to reduce the risk of colonic adenoma and colorectal cancer occurrence or recurrence and are more beneficial in acute inflammatory disorders than in chronic inflammatory diseases, implying that NSAIDs target the early stages of the inflammatory response. Celecoxib inhibits tumor initiation and tumor cell proliferation. Aspirin inhibits the constitutive isoform of the platelet enzyme cyclooxygenase- 1 (COX-1) and the inducible isoform cyclooxygenase-2 (COX-2) which is expressed by cytokines, and some growth factors. In this study, different concentrations of both Celecoxib and Aspirin in various sets were applied to investigate their effects on colon cancer cells (SW480) proliferation and cytokines production. Our result reported a significant decrease in cells viability after the treatment with aspirin and celecoxib alone or in combination. Celecoxib significantly decreased IL-6 levels, while Aspirin treatment showed no significant change in IL-6, IL-12, and TNF- α levels. In conclusion, non-steroidal anti-inflammatory drugs (NSAIDs) have pronounced anti-proliferative effects on colorectal cancer cell lines.

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