Randomized clinical trial (RCT) of a clinical pharmacist intervention to reduce drug misuse and improve inappropriate prescribing in hospitalized patients in province of Al Basra
Keywords:
clinical pharmacist, hospital care, intervention, polypharmacyAbstract
Objective: To determine if a multimodal pharmacist intervention based on medication review, patient interview, and follow-up can minimize the incidence of pharmaceutical prescribing errors between patients receiving clinical pharmacist intervention and patients receiving just usual care. Method: A randomized, controlled trial of 626 patients aged 62 and older with polypharmacy (five chronic drugs) from a general hospital was conducted. During all scheduled appointments, a clinical pharmacist meets with intervention group patients to assess their drug regimens and provide recommendations to them and their doctors. Prescription appropriateness, drug interaction, adverse drug events, medication compliance and knowledge, number of drugs, patient satisfaction, and physician receptivity were the outcome measures. Result: Inappropriate prescribing scores declined significantly more in the intervention group than in the control group (P = 0.0036) There was no difference between groups at condition of life (P = 0.68). Doctors were more receptive to the intervention and followed clinical pharmacist’s recommendations more frequently than they were for control patients (50.63% versus 49.37%). Conclusion: According to this study, involving clinical pharmacists in discovering and discussing prescription discrepancies reduced medication inconsistencies in the medical record.
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