Outcome of high-flow nasal cannula therapy in children with acute respiratory distress in a tertiary care centre
A prospective cohort study
Keywords:
Comfort Score, Clinical Respiratory Score (CRS), High flow nasal cannula, Respiratory distressAbstract
Background: High-flow nasal cannula (HFNC) therapy is a relatively non-invasive new therapy for respiratory distress and has shown potential in reducing invasive ventilation. Recent studies have suggested that HFNC therapy can also be effectively and safely used in patients having respiratory distress with a wider age range of severity and etiologies. Aim: To assess the outcomes of patients placed on a high flow nasal cannula as a primary mode of treatment for children with respiratory distress. Methods: This is a prospective observational study was conducted on patients with acute respiratory distress who require hospitalization in Age groups from 1 month to 12 years old between August 2021 and December 2021 at Tertiary Pediatric Center in Hyderabad. The study was approved by the ethical committee and parental consent was obtained prior to initiation. We calculated a sample size of 350 using 0.05 alpha error and 90% power. Statistical analysis was performed using IBM SPSS23 version (IBM 2015) and significance was assessed at the 0.05 level. Results: A total of 362 children (176girls and 186boys) started HFNC therapy. The HFNC failure occurred in 20 (5.5%) children after a median (IQR) time of 2 (1.75-24) hours.
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