The protective effect of aqueous of Moringa Oleifera seeds extract against levofloxacin drug-induced liver damage in male white rats

Abstract

Objective The goal of this study is to find out how effective Moringa seed (Moringa oleifera) aqueous Extract is in protecting liver tissue from oxidative stress caused by levofloxacin drug . Methods:    24 male albino rats were placed into four groups at random, with six rats in each group being treated for 30 days: Group 1 was a control group, whereas Group 2 was given levofloxacin at a dosage of 10 mg/kg orally by gavage. , The third group received aqueous extracts of   Moringa seeds 650 mg/kg, while the fourth group received aqueous extracts of Moringa seeds 650 mg/kg dose before 4 hours of receive orally at a 10 mg/kg per day dose . Results: The albino rat was considerably protected from levofloxacin-induced liver damage when given the aqueous extract Moringa seeds orally at a concentration of 650 mg/kg body weight. The action of the extract also protected the liver damage caused by the medication, which was indicated by congestion central vein degeneration hepatic cell, necrosis hepatic cell, irregular hepatocyte organization, dilatation and congestion of portal vein , Expandation of sinusoids and increased infiltration of inflammatory cells on histological examination.