Assessment of estrogen receptor marker and smooth muscle actin marker in oral pyogenic granuloma

Nabaa B.  Ali alhussuini; Qaswer M. Alturaihi

doi:10.53730/ijhs.v6nS1.8485

Authors

Nabaa B. Ali alhussuini Collage of dentistry, Kufa University, Najaf/ Iraq
Qaswer M. Alturaihi Collage of medicine, Kufa University, Najaf/ Iraq

Keywords:

Pathogenesis, expression, diagnosis, tissue specimen

Abstract

Soft tissue enlargement of the oral cavity usually existent a diagnostic challenge because many group of pathologic activity can cause these lesions. An enlargement may display a variation of normal anatomic structure, cyst, inflammation, developmental anomalies and neoplasm. These lesions included a group of reactive hyperplasia which arises in response to recurring; chronic tissue injury that provokes vigorous or extreme tissue repair response .so pyogenic granuloma is one of the many common entities in charge of soft tissue enlargement. Objective: The current study aimed to detect the immunohistochemical expressions of ER and alpha smooth muscle actin (α-SMA) for lobular capillary hemangioma (pyogenic granuloma). Material and Methods: fifty cases of confirmed diagnostic pyogenic granuloma were subjected to immunohistochemically assessment by using ER marker and Smooth Muscle Actin marker. Result: The immunohistochemically finding appeared that all 50 cases were positive for SMA marker while only 14 cases were positive for ER marker. So there is no significant difference between ER marker in relation to clinical parameters (age, gender and location) and intensity.

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References

Motta A, González LF, García G, Guzmán J, Prada L, Herrera H, et al. Vascular Malformations. Atlas of Dermatology, Springer; 2022, p. 645–66.

Wollina U, Langner D, França K, Gianfaldoni S, Lotti T, Tchernev G. Pyogenic Granuloma - A Common Benign Vascular Tumor with Variable Clinical Presentation: New Findings and Treatment Options. Open Access Maced J Med Sci 2017;5:423–6. https://doi.org/10.3889/oamjms.2017.111.

Rachappa MM, Triveni MN. Capillary hemangioma or pyogenic granuloma: A diagnostic dilemma. Contemp Clin Dent 2010;1:119.

Kamal R, Dahiya P, Puri A. Oral pyogenic granuloma: Various concepts of etiopathogenesis. J Oral Maxillofac Pathol 2012;16:79–82. https://doi.org/10.4103/0973-029X.92978.

Kavitha M, Prathima GS, Vinothini V, Vigneshwari SK. Recurrent Episodes of Oral Pyogenic Granuloma at Different Site in an 8-year-old Girl: An Unusual Presentation. Int J Clin Pediatr Dent 2021;14:730–3. https://doi.org/10.5005/jp-journals-10005-2033.

Román-Quesada N, González-Navarro B, Izquierdo-Gómez K, Jané-Salas E, Marí-Roig A, Estrugo-Devesa A, et al. An analysis of the prevalence of peripheral giant cell granuloma and pyogenic granuloma in relation to a dental implant. BMC Oral Health 2021;21:1–11.

Velez-Hoyos A, Jimenez-Tobon GA. Highlights of infectious agents in tissue. Pathology 2022.

Aly MM, Abdul-Aziz MA-WM, Elchaghaby MA. A retrospective analysis of oral and maxillofacial pathological lesions in a group of Egyptian children over 21 years. BMC Oral Health 2022;22:1–10.

Harris MN, Desai R, Chuang TY, Hood AF, Mirowski GW. Lobular capillary hemangiomas: An epidemiologic report, with emphasis on cutaneous lesions. J Am Acad Dermatol 2000;42:1012–6.

Koo MG, Lee SH, Han SE. Pyogenic Granuloma: A Retrospective Analysis of Cases Treated Over a 10-Year. Arch Craniofacial Surg 2017;18:16–20. https://doi.org/10.7181/acfs.2017.18.1.16.

Wollina U, Langner D, França K, Gianfaldoni S, Lotti T, Tchernev G. 423 ID Design 2012/DOOEL Skopje, Republic of Macedonia Open Access Macedonian Journal of Medical Sciences. Open Access Maced J Med Sci 2017;5:423–6. https://doi.org/10.3889/oamjms.2017.111.

Kafle G, Garg B, Mehta N, Sharma R, Singh U, Kandasamy D, et al. Diagnostic yield of image-guided biopsy in patients with suspected infectious spondylodiscitis: a prospective study from a tuberculosis-endemic country. Bone Joint J 2022;104:120–6.

Andrikopoulou M, Chatzistamou I, Gkilas H, Vilaras G, Sklavounou A. Assessment of angiogenic markers and female sex hormone receptors in pregnancy tumor of the gingiva. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 2013;71:1376–81. https://doi.org/10.1016/j.joms.2013.03.009.

Godinho G V, Silva CA, Noronha BR, Silva EJ, Volpato LE. Peripheral Ossifying Fibroma Evolved From Pyogenic Granuloma. Cureus 2022;14.

Usui S, Kogame T, Shibuya M, Okamoto N, Toichi E. Case of multiple disseminated cutaneous lobular capillary hemangioma that developed while taking oral contraceptive pills. J Dermatol 2019;46:e202–3. https://doi.org/10.1111/1346-8138.14762.

Abdullah Hasan Jabbar. et, al (2018), Chemical synthesis and characterization of silver nanoparticles induced biocompatibility for anticancer activity. Indian Journal of Public Health Research & Development, 9 (11). pp, 352-357.

Patrice SJ, Wiss K, Mulliken JB. Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases. Pediatr Dermatol 1991;8:267–76. https://doi.org/10.1111/j.1525-1470.1991.tb00931.x.

Alessandrini A, Bruni F, Starace M, Piraccini BM. Periungual Pyogenic Granuloma: The Importance of the Medical History. Ski Appendage Disord 2016;1:175–8. https://doi.org/10.1159/000444302.

]Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937

Zaiac MN, Walker A. Nail abnormalities associated with systemic pathologies. Clin Dermatol 2013;31:627–49. https://doi.org/10.1016/j.clindermatol.2013.06.018.

Cheney-Peters D, Lund TC. Oral Pyogenic Granuloma After Bone Marrow Transplant in the Pediatric/Adolescent Population: Report of 5 Cases. J Pediatr Hematol Oncol 2016;38:570–3. https://doi.org/10.1097/MPH.0000000000000593.