Efficacy of propranolol plus flunarizine combination and valproate monotherapy in migraine prophylaxis in a tertiary care teaching hospital in Western Odisha
Keywords:
flunarizine, propranolol, migraineAbstract
Background: Among various types of headaches, Migraine is very common, universal, and disabling neurological disorder. The average prevalence of migraine is about 18% in women and 6% in men. This study was conducted to evaluate efficacy of propranolol plus flunarizine combination and valproate monotherapy in migraine prophylaxis in a tertiary care teaching hospital in Western Odisha. Materials & Methods: For the present study 58 adult and adolescent (age > 12 years) patients diagnosed with migraine were enrolled equally into 2 groups. Group I patients received Valproate 500 mg once daily dose and group II received Propranolol 40 mg plus Flunarizine 10 mg once daily dose. Parameters such as complete blood count, blood sugar, liver function test, urea, creatinine, sodium, potassium estimation, 12 lead ECG etc. was performed. MIDAS score was also recorded. Results: Group I had 19 males and 10 females and group II had 18 males and 11 females.
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Ichikawa M, Katoh H, Kurihara T, Ishii M. Clinical Response to Valproate in Patients with Migraine. J Clin Neurol. 2016;12(4):468-475.
Bhat, Majid F, Sidhu, Harpreet S, Goyal M. Evaluation of propranolol, flunarizine and divalproex sodium in prophylaxis of migraine. International Journal of Basic & Clinical Pharmacology. 2017;10(6):2463-9.
Dakhale GN, Sharma VS, Thakre MN, Kalikar M. Low-dose sodium valproate versus low-dose propranolol in prophylaxis of common migraine headache: A randomized, prospective, parallel, open-label study. Indian J Pharmacol 2019; 51:255-62.
Reveiz-Herault L, Cardona AF, Ospina EG, Carrillo P. Effectiveness of flunarizine in the prophylaxis of migraine: A meta-analytical review of the literature. Rev Neurol. 2003;36(10):907–12.
Mitsikostas DD, Polychronidis I. Valproate versus flunarizine in migraine prophylaxis: a randomized, double-open, clinical trial. Funct Neurol. 1997; 12(5):267–76.
Aluisio AR, Zehtabchi S. Valproate for Adult Migraine Prophylaxis. Am Fam Physician. 2016;94(9):22
Chowdhury MI, Anwar Ullah AKM, Omar Hassan KM, Majumder S. Sodium Valproate in Migraine Prevention: Efficacy is the same as Propranolol. JAFMC Bangladesh.2012;8(2):32- 8. 8. Bordini CA, Arruda MA, Ciciarelli MC, Speciali J. Propranolol vs flunarizine vs flunarizine plus propranolol in migraine without aura prophylaxis. A double-blind trial. GArq Neuropsiquiatr. 1997;55(3B):536-41.
D’Amico D, Usai S, Grazzi L, et al. The impact of primary headaches on patients’ lives: Italian experience with the MIDAS and the SF-36 questionnaires. Headache Care. 2004;1:123–8. 10. Dakhale GN, Sharma VS, Thakre MN, Kalikar M. Low-dose sodium valproate versus low-dose propranolol in prophylaxis of common migraine headache: A randomized, prospective, parallel, open-label study. Indian journal of pharmacology. 2019 Jul;51(4):255.
Lucas C, Géraud G, Valade D, Chautard MH, Lantéri-Minet M. Recognition and therapeutic management of migraine in 2004, in France: results of FRAMIG 3, a French nationwide population-based survey.Headache. 2006; 46(5):715-25.
Ratul Banerjee, Abhijit Das, Shankar Prasad Nandi, Ananya Mandal. Comparing Efficacy of Propranolol Plus Flunarizine Combination and Valproate Monotherapy in Migraine Prophylaxis in Rural Bengal -A Randomized Control Trial. International Journal of Health and Clinical Research, 2020;3(10):46-53.
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