Formulation and evaluation of inclusion complexed repaglinide with β-cyclodextrin transdermal patches

Simanchal Panda; Sreemoykanti Das

doi:10.53730/ijhs.v6nS1.8590

Authors

Simanchal Panda
simachal@lincoln.edu.my
PhD Scholar, Faculty of Pharmacy, Lincoln University College, Malaysia
Sreemoykanti Das Faculty of Pharmacy, Lincoln University College, Malaysia.

Keywords:

Transdermal drug delivery, penetration enhancers, Diabetes Mellitus, Hypertension

Abstract

Chronic diseases such as diabetes mellitus have high prevalence all over the world. The purpose of the study is to prepare a transdermal patch that can be used to treat diabetes, reducing pill burden and increasing patient compliance. Based on positive results of a feasibility study, including doctor’s opinion and prescription survey, repaglinide was selected as the active ingredients for developing a transdermal patch. The complexation of repaglinide and β cyclodextrin was done by grinding method. The present study was designed to develop Matrix type systems of transdermal patch containing repaglinide- β cyclodextrin complexes, using different polymeric combinations such as Hydroxy Propyl Methyl cellulose (HPMC), Ethyl Cellulose (EC), and Eudragit L100 with Poly vinyl pyrolidone (PVP) by solvent evaporation technique. The patches were subjected to physicochemical parameters, in-vitro drug release and in-vitro skin permeation studies. Good results were obtained in all the evaluated parameters. The developed transdermal delivery system containing complex of repaglinide and β cyclodextrin can further be studied for launching it in market.

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References

Monika B, Amit R, Sanjib B, Alisha B, Mihir P, Dhanushram T. Transdermal drug delivery system with formulation and evaluation aspects: overview. Res J Pharm Technol. 2012;5(9):1168–76.

Prithviraj C, K DB, Sanjib B, Suresh T, Sudip D. Design , Development , Physicochemical and In Vitro Evaluation of Transdermal Patches Containing Verapamil Hydrochloride in Ethyl Cellulose - Povidone Matrices. Res J Pharm Technol. 2009;2(1):168–72.

Ghosal K, Rajan R, Nanda A. Effects of chemical enhancers on the release of glipizide through matrix patch. Int J ChemTech Res. 2009;1(4):1128–30.

Lohora D, Attri K, Yadav M. Preparation and characterization of transdermal patches of repaglinide for the treatment of diabetes. SPER J Pharm Res. 2016;1(1):24–8.

Mishra MK, Sharma R, Ray D. Improved delivery of repaglinide through different polymeric devices. Lat Am J Pharm. 2011;30(7):1291–7.

Mura P, Faucci MT, Parrini PL, Furlanetto S, Pinzauti S. Influence of the preparation method on the physicochemical properties of ketoprofen-cyclodextrin binary systems. Int J Pharm. 1999;179(1):117–28.

Mukherjee B, Mahapatra S, Gupta R, Patra B, Tiwari A, Arora P. A comparison between povidone-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation. Eur J Pharm Biopharm. 2005 Apr;59(3):475–83.

Cherukuri S, Batchu UR, Mandava K, Cherukuri V, Ganapuram KR. Formulation and evaluation of transdermal drug delivery of topiramate. Int J Pharm Investig. 2017;7(1):10–7.

Vijayan V, Jayachandran E, Anburaj J, Rao DS, Jayaraj Kumar K. Transdermal Delivery of Repaglinide from Solid Lipid Nanoparticles in Diabetic Rats: In Vitro and In Vivo Studies. J Pharm Sci Res. 2011;3(3):1077–81.

Iman I, Nadia A, Ebtsam M. Formulation and stability study of chlorpheniramine maleate transdermal patch. Asian J Pharm. 2010;4(1):17–23.

Ghosal K, Rajabalaya R, Maiti AK, Chowdhury B, Nanda A. Evaluation of physicochemical properties and in-vitro release profile of glipizide-matrix patch. Brazilian J Pharm Sci. 2010;46(2):213–8.

Anitha P, Satyanarayana S V. Proniosomal gel mediated transdermal delivery of glibenclamide and atenolol combination: Exvivo and pharmacodynamic studies. Int J Appl Pharm. 2021;13(1):242–8.

Bagchi A, Dey BK. Formulation, in-vitro evaluations and skin irritation study of Losartan potassium Transdermal patches. Iran J Pharm Sci. 2010;6(3):163–70.

Bahadur S, Roy A, Baghel P, Chanda R. Formulation of Glipizide Tablets using Fenugreek Seed Mucilage: Optimization by Factorial Design. Asian J Pharm. 2016;10(4):S662–8.

Bahadur S, Roy A, Baghel P, Choudhury A, Saha S, Chanda R. Formulation and evaluation of glipizide tablets utilizing Hibiscus rosasinensis leaves mucilage. Indones J Pharm. 2018; 29(1):23–8.

Badwaik H R, Sakure K, Nakhate K T, Dhongade H, Kashayap P, Tripathi D K. Microwave assisted eco-friendly synthesis, characterization and in vitro release behavior of carboxymethyl xanthan gum. Curr Microw Chem. 2016; 3(3):203-211.

Badwaik H R, Sakure K, Nakhate K T, Kashayp P, Dhongade H, Alexander A, Tripathi D K. Effect of Ca+ 2 ion on the release of diltiazem hydrochloride from matrix tablets of carboxymethyl xanthan gum graft polyacrylamide. Int J Biol Macromol. 2017; 94:691-697.

Kumar, S. (2022). A quest for sustainium (sustainability Premium): review of sustainable bonds. Academy of Accounting and Financial Studies Journal, Vol. 26, no.2, pp. 1-18

Allugunti, V.R. (2019). Diabetes Kaggle Dataset Adequacy Scrutiny using Factor Exploration and Correlation. International Journal of Recent Technology and Engineering, Volume-8, Issue-1S4, pp 1105-1110.

Sun Y, Du L, Liu Y, Li X, Li M, Jin Y, et al. Transdermal delivery of the in situ hydrogels of curcumin and its inclusion complexes of hydroxypropyl-β-cyclodextrin for melanoma treatment. Int J Pharm. 2014; 469:31-39.