Clinical presentation of hypoglycemic brain injury suggested by neuroimaging in unanticipated term neonates: A retrospective study

Sushree Smita Behura; Avantika Dhanawat; Rama Krushna Gudu; Santosh Kumar Panda

doi:10.53730/ijhs.v6nS1.8719

Authors

Sushree Smita Behura Assistant Professor, Department of Paediatrics, KIMS Hospital Bhubaneswar, Odisha
Avantika Dhanawat Senior Resident, Department of Paediatrics, KIMS Hospital Bhubaneswar, Odisha
Rama Krushna Gudu Senior Resident, Department of Paediatrics, KIMS Hospital Bhubaneswar, Odisha
Santosh Kumar Panda Associate Professor, Department of Paediatrics, KIMS Bhubaneswar, Odisha

Keywords:

Neonatal hypoglycemia, Hypoglycemic brain injury (HBI), Magnetic Resonance Imaging(MRI), Antiepileptic drugs

Abstract

Objective- To evaluate the clinical characteristics of hypoglycemic brain injury (HBI) in unanticipated term neonates, confirmed by neuroimaging. Methodology- We reviewed Magnetic resonance imaging (MRI) of brain of term neonatal encephalopathy cases, from January 2018 to November 2020. Neonates with MRI topography suggestive HBI and documented hypoglycemia from case records were enrolled in study. Perinatal data, clinical characteristics and management of cases was recorded. Descriptive statistics was used to analyse the data. Result-Total 13 term neonates had brain MRI suggestive of HBI conducted at median postnatal age of 7 days. The mean birth weight of HBI neonates was 2582 ± 285 gram, mean gestational age 38.15± 0.48 weeks and five (38.4%) babies were low birth weight. Eight (61.5%) babies were delivered by caesarean section, eleven (84.6%) were first born, twelve (92.3%) were male and nine (69.2%) were on exclusive breastfeeding. Out of thirteen neonates twelve (92.3%) were outborn, mean age of symptom noticed was 2.83±0.53 days and mean age of admission was 3.84± 0.82 days. Mean blood glucose at admission was 28.84±3.23 mg/dl and four (30.7%) were diagnosed with hypoglycemia at referral hospital.

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