A study to determine the effectiveness of dietary supplementation in pediatric patients with nutritional and health concerns
Keywords:
B. lactis, Bone density, leukocyte, Probiotics, PediatricAbstract
Aim: The study's main objective was to see whether the well-known probiotic Bifidobacterium lactis might aid in the development of children. Method: A nine-week clinical study involving 400 children aged between 5 to 10 years, was conducted to evaluate the efficacy of food supplementation. Stage 1 participants took 150 ml of low-fat milk twice a day for three weeks as a baseline diet control. Probiotics (Bifidobacterium lactis) were added to milk during stage 2 in a usual dosage (4×1010 organisms /d) or a low dose (4×109 organisms /d) for 3 weeks. During stage 3, for three weeks, they took low-fat milk. Peripheral blood samples were used to examine changes in the ratios of tumor-cell-killing and leukocyte phagocytic activities. Result: The level of NK cells and T lymphocytes were found to be increased in the blood of the individuals. NK cell’s tumoricidal activity was also increased following B. lactis intake, as were the phagocytic capacities of mononuclear and polymorphonuclear phagocytes. Subjects with weak pretreatment immune responses had the highest improvement in immunity. Conclusion: Supplementing the diets of children with B. lactis (a probiotic) may help improve their cellular immunity and physical development.
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