In vitro and in vivo studies on the wound healing activity of leaf extracts of Homalium zeylanicum benth
Keywords:
homalium zeylanicum, leaf extract, wound healing activity, cell lineAbstract
In this study, the Indian medicinal herb Homalium zeylanicum benth was tested for its ability to cure wounds. A variety of solvents have been used to extract the leaves of the plant. Leaf extract was used for wound healing research both in the laboratory and in animals. HaCaT cells were used to investigate the cytotoxicity of plant extracts, and the IC50 values for the various leaf ethyl acetate extracts were determined. All doses of the test samples indicated reduced cytotoxicity on the tested cell line. Scratch assays were used to measure the migration rates of HaCaT cells. During an in vivo study, animals treated with ethyl acetate leaf extract had higher percentages of wound contraction power and tensile strength.. According to this study, the plant's leaf extract may have wound-healing properties, which is in line with its traditional medicinal uses.
Downloads
References
Gupta, A., Singh, R.L., and Raghubir, R. Antioxidant status during cutaneous wound healing in immunocompromised rats. Mol. Cell. Biochem., 2002, 241:1-7.
Russo, A., Longo, R., and Vanella, A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterpia., 2002, 73: S21-S29.
Meenakshi, S., Raghavan, G., Virendra, N., Ajay Kumar, S.R., and Shanta, M. Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum. Journal of Ethnopharmacology., 2006, 107:67-72.
Kumar, B., Vijay kumar, M., Govidarajan, R., and Pushpangadan, P. Ethanopharmacological approaches to wound healing- exploring medicinal plants of india. Journal of Ethnopharmacology., 2007, 114:103-113.
International plant name index [homepage on internet]. 2004. Available from: http://www.ipni.org/ipni/idplantnamesearcg.do.
Sue Zmarzty Don Krikup, herbarium, Kew. Interactive Key to Genera of Salicaceaesensulato and Achariaceaesensulato. www.kew.org/herbarium/ keys/flacs/_baks/index.html.0006.d323.bak.
Sililan K. Homaliumzeylanicum (Gardner) Bentham. J Linn Soc Bot.1859:(4):35
SwathiPothireddy, International Journal of Research and Development in Pharmacy and Life Sciences,2014:3(3):1004-1010.
Rachalavinodkumar, phytochemical constituents and biological activities of Homaliumzeylanicumbenth, Int J Pharm Bio Sci,2014:5(3):176 – 182
K. Siva Sankara Prasad, assessment of the analgesic and anti-inflammatory effect of Homaliumzeylanicum, JGTPS,2014:5(3): 1886 –1890
Kumar dileep, Clinical evolution of Sarpagandhachurna in the management of Yoshaapasmara vis-à-vis hysterical neurosis, IRJP, 2014:5(3):174-177.
Natava Rajesh, In -vitro and In-vivo Studies on the Antidiabetic Activity of Stem Bark of Homaliumzeylanicum in STZ Induced Diabetic Rats, Asian Journal of Biochemical and Pharmaceutical Research,2014:4(3):76-90.
Tim Mosmann. Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. Journal of lmmunological Methods, 65 (1983) 55-63.
M. Harishkumar, Y. Masatoshi, S. Hiroshi, et al., Revealing the mechanism of in vitro wound healing properties of citrus tamurana extract, BioMed Res. Int. (2013) 2013
Cooper., and Gunn’s. In: Carter, S.L. (Ed.), Dispensing for Pharmaceutical Students, 12th ed. CBS Publisher and Distributors, Delhi, 1987, 199–200.
S. Hemalata, N. Subramanian, V. Ravichandran, and K. Chinnaswamy, “Wound healing activity of Indigofera ennaphylla Linn,” Indian Journal of Pharmaceutical Sciences, vol. 63, no. 4, pp. 331–333, 2001.
Kondo, T., Timing of skin wounds. Legal Medicine., 2007, 9, 109–114.
Arnawa, I.K., Sapanca, P.L.Y., Martini, L.K.B., Udayana, I.G.B., Suryasa, W. (2019). Food security program towards community food consumption. Journal of Advanced Research in Dynamical and Control Systems, 11(2), 1198-1210.
Damayanti, I. A. M., Indrayoni, P., Antari, N. W. S., & Padmiswari, A. A. I. M. (2021). Effectiveness of Averrhoa bilimbi leaf extract on spermatogenic cells of mice (Mus Musculus L.) hyperglycemia. International Journal of Health & Medical Sciences, 4(2), 273-279. https://doi.org/10.21744/ijhms.v4n2.1747
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
