Study of hepatic involvement in falciparum malaria
A hospital based study in South Odisha
Keywords:
Malaria Hepatopathy, Malaria, malaria hepatitis, Malarial JaundiceAbstract
Background: Malaria is a major hindrance to economic development. It is caused due to infection with Plasmodium and transmitted to human by bite of female anopheles mosquito. Orissa contributes to about 20% of malaria cases to the national total, out of which 85% are P. falciparum cases. 40% of country's malarial deaths occur in the state. In Odisha out of 39,556 positive case and 9 deaths in year 2019. Material and Methods: This prospective case series study was conducted to understand the clinical profile of 60 complicated malaria cases presenting with jaundice out of 450 hospitalized patients diagnosed with acute severe malaria. All cases were treated with quinine dihydrochloride IV 600 mg 8 hourly for 3-4 days, then given orally for a total of 7 days. Results: In the present study forty five cases were males and 15 were females showing a male female ratio 3:1. Maximum cases around 39 (65%) belong to age group from 15-35 years. Fever was the presenting complaint in all cases in this study. The range of temperature varied between 100-103°F. Added to these the cerebral symptoms present in 24 (40%) cases would reasonably justify a clinical diagnosis of Falciparum infection.
Downloads
References
https://www.who.int/malaria/publications/world-malaria-report-2018/report/en/.
Dondorp A, Nosten F, Stepniewska K, Day N, White N. Arte-sunate versus quinine for treatment of severe falciparummalaria: a randomised trial. Lancet 2005;366:717—25.
Menezes RG, Pant S, Kanchan T, Senthilkumaran S,Kharoshah MA, Naik R, et al. Malaria: an infection withglobal impact. In: Peterson AM, Calamandrei GE, editors.Malaria: etiology, pathogenesis, and treatments. New York:Nova Science Publishers; 2011.
Menezes RG, Kanchan T, Rai S, Rao PPJ, Naik R, Shetty BSK,et al. An autopsy case of sudden unexplained death causedby malaria. J Forensic Sci 2010;55:835—8.
Menezes RG, Pant S, Kharoshah MA, Senthilkumaran S, ArunM, Nagesh KR, et al. Autopsy discoveries of death frommalaria. Leg Med (Tokyo) 2012;14:111—5.
Kausar MW, Moeed K, Asif N, Rizwi F, Raza S. Correlationof bilirubin with liver enzymes in patients of falciparummalaria. Intl J Pathol 2010;8:63—7.
Baheti R, Laddha P, Gehlot RS. Liver involvement infalciparum malaria—–a histo-pathological analysis. JIACM2003;4:34—8.
Severe falciparum malaria, World Health Organization,Communicable Diseases Cluster. Trans R Soc Trop Med Hyg2000;94:S1—90.
Gupta UC, Kataria ML. Plasmodium falciparum hepatitis during malaria epidemic. J Assoc Physicians India 1993;41:292.
Anand AC Puri,P. jaundice in malaria J Gastroenterol Hepatol 2005 ;20:1322-32
Anand AC, Ramji C, Narula AS, Singh W. Malarial hepatitis:a heterogeneous syndrome? Natl Med J India 1992;5:59—62.
Sabcharoen A, Chongsuphajaisiddhi T, Attanath P. Serum quinine concentrations following the initial dose in children with falciparum malaria. Southeast Asian J Trop Med Public Health 1989;13:556-62.
Muddaiah M, Prakash PS. A study of clinical profile ofmalaria in a tertiary referral centre in South Canara. JVector Borne Dis 2006;43:29—33.
Camara B, Diagne-Gueye NR, Faye PM, Fall ML, Ndiaye JL,Ba M, et al. Malaria severity criteria and prognostic factors among children in Dakar. Med Mal Infect 2011;41:63-7.
Golja J, Nahorski W, Felczak-korzybska I, Myjak P. Liver injury in the course of malaria. Int. Marit Health 2000;51:30-
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.