Study of some microbial infections of recurrent miscarriage in women

Oruba K. Al-Bermani; Israa Adnan Ibraheam; Nada Naji Shaalan; Ali Malik Saad

doi:10.53730/ijhs.v6nS5.9074

Authors

Oruba K. Al-Bermani Dep. Biology, College of Science for Women, University of Babylon, Iraq
Israa Adnan Ibraheam Dep. Biology, College of Science for Women, University of Babylon, Iraq
Nada Naji Shaalan College of Education for Pure Sciences, University of Karbala, Iraq
Ali Malik Saad Dep. Biology, College of Science for Women, University of Babylon, Iraq

Keywords:

recurrent miscarriage, Typhoid fever, ToRCH test

Abstract

Background: some microbial infections can be passed to the fetus before or during birth and damage the fetus or cause a miscarriage, like infection with ToRCH agents and salmonella enterica. The current study aims to investigate the extent of the involvement of salmonella enteria serovars, proteus spp. and Brucella spp. in recurrent miscarriage in women during first trimester. Material and method: The 50 blood samples were collected from women age rage (19-39), who had repeated miscarriages during the first trimester during periods extended from October 2021 to February 2022,. The study control includes the 20 fertile women with no miscarried history. Two tests were conducted which are ToRCH IgM and febril antigen slid test for identification infectious agents associated with pregnancy loss. Results: The present results showed that the most frequent recurrent miscarriage (RM) was in the age group 35-39 years at a percentage 34%, while the lowest abortion rate was 18% at the age group of 25-29 years.

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References

Giakoumelou S., Wheelhouse N., Cuschieri K. et al. (2016).The role of infection in miscarriage. Hum Reprod Update;22(1):116-133.

Kolte A.M., Bernardi L.A., Christiansen O.B. et al.( 2015). Terminology for pregnancy loss prior to viability: a consensus statement from the ESHRE early pregnancy special interest group. Hum Reprod;30(3):495–8.

Silver R.M., Branch D.W., Goldenberg R., IamsJ.D.and Klebanoff M.A.(2011). Nomenclature for pregnancy outcomes: time for a change. Obstet Gynecol;118(6):1402–8.

Cohain J.S., Buxbaum R.E., Mankuta D. (2017). Spontaneous first trimester miscarriage rates per woman among parous women with 1 or more pregnancies of 24 weeks or more. BMC Pregnancy Childbirth;17(1):437.

Hussien S.S, Mohammed S.A and Salih B.M.(2020). Prevalence of Bacterial Vaginitis in Women with Recurrent Abortion in Comparison with Normal Pregnant Women Medico-Legal Update 20 (4): 1891-1895

Li T.C., Makris M., Tomsu M., Tuckerman E. and Laird S.(2002). Recurrent miscarriage: aetiology, management and prognosis. Human Reproduction Update, Vol.8, No.5 pp. 463±481

Salmanov A.G., Ishchak O.M., Shostak Y.M., Kozachenko V.V., Rud V.O., Golyanovskiy O.V. and Shkorbotun V.O.(2021). Bacterial causes of pregnancy loss and premature birth in the women in Ukrain.WLek 74(6):1355-1359

Giakoumelou S., Wheelhouse N., , Cuschieri K. ,3 Entrican G ,2,4 Sarah E.M. Howie,5 and Horne A. W. (2015).T he role of infection in miscarriage. Hum Reprod Update. 2016 Jan; 22(1): 116–133

Kumar H., Singh V A, Isha M, Mehta S, Garg R, Shinu P.(2018). Line Immunoassay: A Rapid Test for Screening TORCH Complex in Antenatal Patients with Bad Obstetric History. Mymensingh Med J. 2018 Jul;27(3):641-644

Marguerite B. Vigliani1 and Anna I. Bakardjiev2.(2013). First Trimester Typhoid Fever with Vertical Transmission of Salmonella Typhi, an Intracellular Organism Case Reports in Medicine.Hidawi

Almasi M, Masahebi M, Soheilipour Z, Hatami H, Saadat S. (2019). Septic Abortion Associated with Salmonella enterica Serotype Typhi in a Patient with Negative Widal Test ;SJMR. 4 (3) :155-159

Magnus M. C, Wilcox A. J., MorkenN.H., Weinberg C.R., Håberg S.E.(2019). Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study.BMJ364:l869

Cohain J. S., Buxbaum2 R.E. and Mankuta D.(2017). Spontaneous first trimester miscarriage rates per woman among parous women with 1 or more pregnancies of 24 weeks or more. BMC Pregnancy and Childbirth Dec 22;17(1):437

Chaouat G. (2003).Innetaly moving amay from the Th1/Th2 paradigm in pregancy. Clin Exp immunology; 131:393-5.

Delcourt C., cyr Y.J., Vo B., and Yildiz H.(2018). Salmonella enteritidis during pregnancy, a rare cause of septic abortion: case report and review of the literature. Journal of Obstetrics and Gynaecology 39(4)

yinon Y., farine D., yudin M.H and et al.(2010). Cytomegalovirus Infection in Pregnancy, SOGC CLINICAL PRACTICE GUIDELINE, No.240:348-354

Noto Llana M., Sarnacki S.H., Castañeda A. , Mdel R., Pustovrh M.C., Gartner A.S., Buzzola F.R. and et al.(2014). Salmonella enterica serovar Enteritidis enterocolitis during late stages of gestation induces an adverse pregnancy outcome in the murine model. PLoS One;9:e111282.

Kaistha N. ,1 Singla N. ,2 Bansal N. ,3 and Chander J .(2013). Salmonella Typhi Isolation in a Pregnant Woman: Determining the Importance. J Clin Diagn Res. 7(9): 2100–2101

Jain A., Jaggi N. and Maheshwari D. (2020). Partially Treated Typhoid fever Leading to Inevitable Abortion: A Case Repor . Obstetrics and Gynaecology . 14 (06)

Pejcic-Karapetrovic .B., Gurnani .K., Russell M. S., Finlay B. B., Sad S. and. Krishnan L. (2007) “Pregnancy impairs the innate immune resistance to Salmonella typhimurium leading to rapid fatal infection,” Journal of Immunology, vol. 179, no. 9, pp. 6088–6096

Chattopadhyay A., Robinson N., Sandhu J. K., Finlay B., Sad S. and Krishnan L.(2010). “Salmonella enterica serovar typhimuriuminduced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease,” Infection and Immunit. 78(5): 2292–2301