Synthesis and characterization of new 1,3-Oxazepine-4,7-dione compounds from 1,2-diaminobenzene
Keywords:
1,3-oxazepine, Schiff bases synthes, Cyclo addition, biological activityAbstract
In this research, done synthesized a series of new 1,3-oxazepine-4,7-dione derivatives as D1-D3 compounds via using [2+5] cycloaddition reaction. Synthesized compounds that have been bis azo groups [B1-B3] from 1,2-diaminobenzene via coupling its diazonium salt with phenoxide anion of 4-alkoxybenzaldehyde which Alkoxy was as pentyl, hexyl, and Heptyl groups. These compounds B1-B3 are condensed with 4-Bromoaniline in Schiff bases reactions to give bisazoimine derivatives C1-C3. The compounds C1-C3 were produced by cycloaddition reaction to produce 1,3-oxazepine-4,7-dione derivatives D1-D3. The structures of the synthesized compounds are characterized by spectroscopic methods, such as FTIR, and 1HNMR spectra with the elemental composition analysis. The compounds D1-D3 that are synthesized play a big role in the inhibition of growth.
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