Synthesis and characterization of novel metal complexes with new azo -schiff base ligand derived from isatin and toxicological studies of its complexes as antibacterial

Abstract

A New Azo-base-ligand was prepared [4-(( (Z)-(2,4-diclorophenyl)diazenyl)-3-((Z)-2-oxoindoline-3-ylidene)amino), (4DCPD)]-(Pyrimidine-2-yl)benzenesulfonamide). This ligand (4DCPS) with the metal ions Co(II), Ni(II) and Cu was also prepared in reaction to three chelate complexes (II). UV-Vis. Ligand along with its metal complexes were investigated based on spectra. In comparison to the one from free ligand, the (UV-Vis) electronic complex spectra showed bathochromic shifting. The Free ligand spectrum Mass & 1HNMR has been taken and the Ligand FTIR spectra and its chelating complexes studied, indicating that there is coordination among the metal ions and the prepared ligand. A conductivity and magnetics, an elementary micro-analysis and the metal ion percentage were identified. The geometrical structure of the co(II), Ni(II) and Cu preparations depends on the results of these projects (II) and they are octahedral. The mole-ratio (M:L) is (1:2). The conductivity measurements show non-electrical properties, for all prepared complexes.The final stage involved the study of the biological activity of prepared component to two type of pathogenic bacteria: (G+) Staph. aureus and Escherichia coli (G-) using Well diffusion methods .Three different concentration were tested  (100 ,500, 1000) ppm in Ethanol Absolute(99%) as a solvent . The prepared compounds showed different results (high, moderate, low, and inactive).