Correlation between CK-MB, TSH, LDL, HDL, Troponin T, Troponin I and myocardial infarction
Keywords:
high-sensitivity cardiac troponin T, troponin I, myocardial infarction, CKMB, TSH, LDHAbstract
Introduction: The assessment of patients with acute chest pain of possible cardiac cause continues to be a challenge and positive diagnosis has psychological, social and legal implications. The presence of ST segment elevation in the ECG is highly specific (but only about 50% sensitive) for acute myocardial infarction (MI). However, many patients presenting to coronary care units has chest pain without ST elevation in the ECG. The diagnostic possibilities in these cases include: acute coronary syndrome in evolution, or ‘non-ischaemic’ chest pain. The World Health Organization defines for diagnosing AMI, the presence of two of the three enlisted features namely, symptoms of myocardial ischemia, elevated levels of cardiac marker (protein or enzyme) concentrations in the blood, and a typical electrocardiographic pattern involving the development of Q waves or persistent T wave changes. Methods: In this Prospective study, the data of the registry maintained in the Department of biochemistry, Tertiary care Teaching Hospital were analysed. The WHO case definition was used to assign a diagnosis in 430 patients presenting to the emergency department with symptoms of cardiac ischemia.
Downloads
References
Thygesen, K., et al., Universal definition of myocardial infarction. Eur Heart J 2007. 28(20): p. 2525-2538.
Mohammed, A.A. and J.L. Januzzi, Jr., Clinical applications of highly sensitive troponin assays. Cardiol Rev 2010. 18(1): p. 12-9.
Waxman, D.A., et al., A model for troponin I as a quantitative predictor of in-hospital mortality. J Am Coll Cardiol 2006. 48(9): p. 1755-62.
Melanson, S.E., D.A. Morrow, and P. Jarolim, Earlier detection of myocardial injury in a preliminary evaluation using a new troponin I assay with improved sensitivity. Am J Clin Pathol 2007. 128(2): p. 282-6.
Wallace, T.W., et al., Prevalence and determinants of troponin T elevation in the general population. Circulation 2006. 113(16): p. 1958-65.
Moe KT et al "Current trends in diagnostic biomarkers of acute coronary syndrome"(PDF). Ann. Acad. Med. Singap. ;2010; 39 (3): 210–5.
Munther K. et al ;Tufts-New England Medical Center Spring. 2008;
Mehta, PK; Wei, J; Wenger, NK ;Ischemic heart disease in women: A focus on risk factors.". Trends in Cardiovascular Medicine ;(2014);"25 (2): 140–151.
Dernellis J et al ; Effects of thyroid replacement therapy on arterial blood pressure in patients with hypertension and hypothyroidism, Am Heart J, ;2002; ;143:718–24.
Klein I, Danzi S,; Thyroid disease and the heart, Circulation, ; 2007; 116:1725–35.
Pantos C, Mourouzis I, Cokkinos DV. Rebuilding the post-infarcted myocardium by activating ‘physiologic’ hypertrophic signaling pathways: the thyroid hormone paradigm.
Pantos C, Mourouzis I, Cokkinos DV. New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider.
Pantos C, Mourouzis I, Saranteas T, Brozou V, Galanopoulos G, Kostopanagiotou G, Cokkinos D. Acute T3 treatment protects the heart against ischemia–reperfusion injury via TRalpha1 receptor. Molecular and Cellular Biochemistry 2011 In Press.
Ezekowitz JA, Kaul P, Bakal JA, Armstrong PW, Welsh RC, Mcalister FA. Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction. Journal of the American College of Cardiology 2009 53 13–20.
Reddy2T8T et al 2T;Ischemia-modified albumin levels in overt and subclinical hypothyroidism;8TJournal of Endocrinological Investigation8T10T 2T10T2015 2T10T;10T(4);1-6
Hauck, J.S. and Bartke, A. ;Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase. Free. Rad. Biol. Med., ;(2000); 28: 970-979.
Sayfullaevich, P. S. (2021). Clinical and pathogenetic approaches to early rehabilitation of ischaemic stroke patients. International Journal of Health & Medical Sciences, 4(4), 373-380. https://doi.org/10.21744/ijhms.v4n4.1788
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
