Evaluation of folate levels in patients of lung carcinoma

Rubal Singh; Jaiprakash Yogi; Bushra Fiza; Maheep Sinha

doi:10.53730/ijhs.v6nS5.9373

Authors

Rubal Singh PhD Scholar, Department of Biochemistry, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India
Jaiprakash Yogi
jpyogi20@gmail.com
Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India
Bushra Fiza Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India
Maheep Sinha Emeritus Professor, Department of Biochemistry, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India

Keywords:

Tobacco Smoking, S. Folate, Lung Carcinoma

Abstract

Introduction: Lung cancer is the leading cause of cancer death globally. It is the malignant lung tumor with numerous histological variants. Due to the increasing number of tobacco smoking it is the major risk factor for lung cancer. Two main types of Lung cancer are Non-Small cell lung carcinoma (NSCLC) and Small cell lung carcinoma (SCLC). Folate is a water-soluble natural form of vitamin B9. It plays important role in homocysteine metabolism. Its decreased level may be associated with various cancers as is linked with altered DNA methylation and synthesis, and disruption of DNA repair activities. Aims: The present study was planned to evaluate the Serum Folate levels in patients diagnosed with lung carcinoma and to explore the association of increased serum folate levels with lung carcinoma patients. Materials & Methods: Fifty patients diagnosed for lung carcinoma were enrolled according to the inclusion criteria for the study. Fifty age and sex matched healthy individuals constituted the control group. Serum folate levels were estimated for all enrolled subjects. Results obtained were compared statistically among the lung carcinoma and healthy control groups. Results: Age of the study group and control group were comparable.

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References

Zamay TN, Zamay GS, Kolovskaya OS, Zukov A, Petrova MM, Gargaun A et al. Current and Prospective Protein Biomarkers of Lung Cancer. Cancers 2017 Nov; 9: 1-22.

Brett CB, Charles SD Cruz. Lung cancer 2020 Epidemiology, etiology, and prevention. Clin Chest Med 2020 Mar; 41: 1-24.

Larsen J E, Minna J D. Molecular Biology of Lung Cancer: Clinical Implications. Clin Chest Med. 2011; 32(4):703–40.

Brzeziańska E, Dutkowska A, Antczak A. The significance of epigenetic alterations in lung carcinogenesis. MolBiol Rep. 2013; 40(1):309–25.

Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003; 349:2042–54.

Langevin SM, Kratzke RA, Kelsey KT. Epigenetics of lung cancer. Transl Res. 2015; 165(1):74–90.

Choi SW, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr. 2000; 130(2):129–132.

Li H, Dai SX, Zheng JJ, Liu JQ, Huang JF. Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency. Nutrients.2015 Aug 10; 7(8):6670–87.

Wettergren Y, Odin E, Carlsson G, Gustavsson B. MTHFR, MTR, and MTRR Polymorphisms in Relation to p16INK4A Hypermethylation in Mucosa of Patients with Colorectal Cancer. Mol Med. 2010 Sep Oct; 16(9–10):425–32.

Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y. Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population. BMC Cancer. 2011; 11:459.

Cui LH, Yu Z, Zhang TT, Shin MH, Kim HN, Choi JS. Influence of polymorphisms in MTHFR 677 C!T, TYMS 3R!2R and MTR 2756 A!G on NSCLC risk and response to platinum-based chemotherapy in advanced NSCLC. Pharmacogenomics. 2011; 12:797–808.

Rakhmonov, O. M., Shadmanov, A. K., & Juraev, F. M. (2021). Results of endoscopic treatment of benign prostatic hyperplasia in patients with metabolic syndrome. International Journal of Health & Medical Sciences, 5(1), 21-25. https://doi.org/10.21744/ijhms.v5n1.1811

Suzuki T, Matsuo K, Hiraki A, Saito T, Sato S, Yatabe Y, et al. Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study. Carcinogenesis. 2007; 28:1718–1725.

Liu CS, Tsai CW, Hsia TC, Wang RF, Liu CJ, Hang LW, et al. Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients. Cancer Genomics Proteomics. 2009; 6:325–329.

Shi Q, Zhang Z, Li G, Pillow PC, Hernandez LM, Spitz MR, Wei Q. Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis. Pharmacogenetic Genomics. 2005; 15(8):547–55.

Shi Q, Zhang Z, Li G, Pillow PC, Hernandez LM, Spitz MR, Wei Q. Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms. Cancer Epidemiol Biomarkers Prev. 2005; 14(6):1477–84.

Shen H, Wei Q, Pillow PC, Amos CI, Hong WK, Spitz MR. Dietary folate intake and lung cancer risk in former smokers: a case-control analysis. Cancer Epidemiol Biomarkers Prev. 2003;12(10):980–6.

Tastekin D, Erturk K, Bozbey HU, Olmuscelik O, Kiziltan H, Tuna S, et al. Plasma homocysteine, folate and vitamin B12 levels in patients with lung cancer. ExpOncol. 2015;37(3):218–22.

Jatoi A, Daly BD, Kramer G, Mason JB. Folate status among patients with non-small cell lung cancer: a case-control study. J Surg Oncol. 2001;77:247–252.

Marchand LL, Yoshizawa CN, Kolonel LN, Hankin JH, Goodman MT. Vegetable consumption and lung cancer risk: a population-based case-control study in Hawaii. J Natl Cancer Inst. 1989; 81(15): 1158–64.

Bandera EV, Freudenheim J L, Marshall J R, Zielezny M, Priore R, Brasure J, et al. Diet and alcohol consumption and lung cancer risk in the New York State Cohort. Cancer Causes Control. 1997;8:828–840.

Johansson M, Relton C, Ueland PM, Vollset SE, Midttun Ø, Nygård O, et al. Serum B vitamin levels and risk of lung cancer. JAMA. 2010;303(23):2377–2385 doi: 10.1001/jama.2010.808

Hartman TJ, Woodson K, Stolzenberg-Solomon R, Virtamo J, Selhub J, Barrett M J, et al. Association of the B-vitamins pyridoxal 5′-phosphate (B(6)), B(12), and folate with lung cancer risk in older men. Am J Epidemiol. 2001;153:688–694.

Kabat GC, Miller AB, Jain M, et al. Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer. 2008; 99: 816–821.

Slatore CG, Littman AJ, Au DH, Satia JA, et al. Long-Term Use of Supplemental Multivitamins, Vitamin C, Vitamin E, and Folate Does Not Reduce the Risk of Lung Cancer. Am J RespirCrit Care Med. 2008; 177: 524–530.

Roswall N, Olsen A, Christensen J, et al. Source-specific effects of micronutrients in lung cancer prevention. Lung Cancer. 2010; 67: 275–281.

Takata Y, Xiang YB, Yang G, et al. Intakes of Fruits, Vegetables, and Related Vitamins and Lung Cancer Risk: Results from the Shanghai Men's Health Study (2002–2009). Nutr Cancer. 2013; 65: 51–61.

Rinartha, K., Suryasa, W., & Kartika, L. G. S. (2018). Comparative Analysis of String Similarity on Dynamic Query Suggestions. In 2018 Electrical Power, Electronics, Communications, Controls and Informatics Seminar (EECCIS) (pp. 399-404). IEEE.

Dai W, Yang B, Chu X, Wang Y, Zhao M, Chen L, et al. Association between folate intake, serum folate levels and the risk of lung cancer: a systematic review and meta-analysis. Chin Med J. 2013;126(10):1957–1964

Pfeiffer CM, Fazili Z, Zhang M. Folate analytical methodology In: Bailey L.B., editor. Folate in Health and Disease. 2nd. CRC Press; Boca Raton, FL, USA; 2010. pp. 179–204.