Comparison between post treatment vascular density, fractal dimension and choriocapillaris flow in ischemic and non-ischemic retinal vein occlusion using optical coherence tomography angiography
Keywords:
retinal vein occlusion, optical coherence tomography angiography, anti–vascular endothelial growth factor, macular edema, retinaAbstract
The aim of the study was to compare vascular density (VD), fractal dimension (FD), foveal avascular zone (FAZ) and choriocapillaris flow and using optical coherence tomography angiography (OCTA) before and after Bevacizumab therapy in patients with macular edema associated with ischemic and non-ischemic retinal vein occlusion (RVO). 15 eyes with ischemic RVO and 20 with non-ischemic RVO were included. Each patient had 3 consecutive intravitreal injections of Bevacizumab every month. Best-corrected visual acuity (BCVA), central macular thickness (CMT) and retinal microvasculature were measured using OCTA before and one month after the third injection. The BCVA and FAZ area improved significantly after treatment in both ischemic and non-ischemic cases. Although, in ischemic group, FD, superficial and deep capillary VD decreased with no statistically significant change in the choriocapillaris flow. In the non-ischemic group, there was an increase in the FD, superficial parafoveal, perifoveal VD and choriocapillaris flow with insignificant increase in the DCP VD while the foveal VD showed a statistically significant decrease. In conclusion, anti-VEGF therapy improved the BCVA, retinal FD, VD in non-ischemic case but despite improvement in BCVA it reduced the VD in the ischemic cases.
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Boyd, S.R., Zachary, I., Chakravarthy, U., et al. (2002). Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion. Arc Ophthalmol, 120(12), 1644–1650.
Chan YH. (2003). Biostatistics 102: Quantitative Data – Parametric & Non-parametric Tests. Singapore Med J, 44(8), 391-396.
Chan YH. (2003). Biostatistics 104: Correlational Analysis. Singapore Med J, 44(12), 614-619.
De Carlo, T.E., Chin, A.T., Joseph, T., et al. (2016). Distinguishing Diabetic Macular Edema From Capillary Nonperfusion Using Optical Coherence Tomography Angiography. Ophthalmic Surg Lasers Imaging Retina, 47(2), 108–114
Deng, Y., Zhong, Q.W., Zhang, A.Q., et al. (2019). Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography. Int J Ophthalmol, 12(5), 802–808.
Ghasemi, F.K., Iafe, N.A., Hubschman, J.P., et al. (2017). Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion. Invest Ophthalmol Vis Sc.i, 58(1), 30-34.
Glacet-Bernard, A., Sellam, A., Coscas, F., et al. (2016). Optical coherence tomography angiography in retinal vein occlusion treated with dexamethasone implant: a new test for follow-up evaluation. Eur J Ophthalmol, 26(5), 460–468.
Jia, Y., Tan, O., Tokayer, J. et al. (2012). Split-Spectrum Amplitude- Decorrelation Angiography with optical coherence tomography. Opt Express, 20, 4710-4725.
Kim, I., Moon, S.O., Kim, S.H., et al. (2001). Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem, 276(10), 7614–7620.
Lumbroso, B. & Rispoli, M. (2015). Fluorescein Angiography and Optical Coherence Tomography Angiography: Advantages and Disadvantages. Clinical Guide to Angio-OCT, 1st edition, Chap 9, 68-70.
Mané, V., Dupas, B., Gaudric, A., et al. (2016). Correlation between cystoid spaces in chronic diabetic macular edema and capillary nonperfusion detected by optical coherence tomography angiography. Retina, 36, Suppl 1, S102–S110.
Mastropasqua, R., Toto, L., Di Antonio, L., et al. (2016). Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions. Sci Rep, 7, 40763.
Micieli, J.A., Tsui, E., Lam, W.C., et al. (2012). Retinal blood flow in response to an intravitreal injection of ranibizumab for neovascular age-related macular degeneration. Acta Ophthalmol, 90, e13–e20.
Mir, T.A., Kherani, S., Hafiz, G., et al. (2016). Changes in retinal nonperfusion associated with suppression of vascular endothelial growth factor in retinal vein occlusion. Ophthalmology, 123, 625–634.e1
Nicolai, M., Franceschi, A., Turris, S., et al. (2019). Papillary Vessel Density Changes After Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study. J Clin Med, 8(10), 1636.
Novais, E.A., Waheed, N.K. (2016). Optical Coherence Tomography Angiography of Retinal Vein Occlusion. Dev Ophthalmol, 56, 132–138.
Papadopoulou, D.N., Mendrinos, E., Mangioris, G. et al. (2009). Intravitreal ranibizumab may induce retina arteriolar vasoconstriction in patients with neovascular age related macular degeneration. Ophthalmology, 116, 1755–1761.
Sacu, S., Pemp, B., Weigert, G., et al. (2011). Response of retinal vessels and retrobulbar hemodynamics to intravitreal anti-VEGF treatment in eyes with branch retinal vein occlusion. Invest Ophthalmol Vis Sci, 52, 3046–3050.
Sellam, A., Glacet-Bernard, A., Coscas, F., et al. (2017). Qualitative and quantitative follow-up using optical coherence tomography angiography of retinal vein occlusion treated with anti-VEGF Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion. Retina, 37(6), 1176–1184.
Sophie, R., Hafiz, G., Scott, A.W., et al. (2013). Long-term outcomes in ranibizumab-treated patients with retinal vein occlusion; the role of progression of retinal nonperfusion. Am J Ophthalmol, 156, 693–705.
Spaide, R.F. (2016). Volume-Rendered Optical Coherence Tomography of Retinal Vein Occlusion Pilot Study. Am J Ophthalmol, 165, 133–144.
Sun, Y., Jin, K., Xie, L., et al. (2003). VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest, 111(12), 1843–1851.
Suzuki, N., Hirano, Y., Tomiyasu, T., et al. (2016). Retinal Hemodynamics Seen on Optical Coherence Tomography Angiography Before and After Treatment of Retinal Vein Occlusion. Invest Ophthalmol Vis Sc, 57(13), 5681–5687.
Winegarner, A., Wakabayashi, T., Fukushima, Y., et al. (2018). Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci, 59(7), 2708-2716.
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