Role of cerebro-placental ratio in prediction of perinatal outcome in high-risk Pregnancies with intrauterine growth restriction
Keywords:
cerebro-placental ratio, growth restriction, high-risk pregnancies, intrauterine, perinatal outcomeAbstract
Background: Antenatal surveillance using Doppler ultrasound velocimetry of the uteroplacental umbilical and fetus arteries has been commonplace. The cerebroplacental ratio has been investigated as a way to predict newborn outcomes. Aim and objectives: In this research, we wanted to see whether the cerebro-placental ratio may help predict perinatal outcomes in high-risk gestation with intrauterine growth restriction. Subjects and methods: This was case-control research done at Al-Hussein University Hospital's Department of Obstetrics and Gynecology; The obstetric color Doppler investigation might be examined in two groups of 100 high-risk pregnant wome: Group Ⅰ - study group: 50 high risk pregnant women with IUGR and Group Ⅱ - control group: 50 high risk pregnant women without IUGR. Results: CPR achieved significance at cutoff point of 1.03 for predicting IUGR with sensitivity of 87.2% and specificity of 71.6% with PPV 83% and NPV 79%. Conclusion: Intrauterine growth restriction in high-risk gestations, the cerebral-placental ratio has a significant prognostic value for perinatal outcome.
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References
Sharma D, Shastri S, Sharma P. Intrauterine growth restriction: antenatal and postnatal aspects. Clinical Medicine Insights: Pediatrics, 2016; 10: CMPed-S40070,
ACOG (American College of Obstetricians and Gynecologists). Intrauterine growth restriction. Practice Bulletin. 2000, No. 12.
Devaskar SU and Chu A. Intrauterine growth restriction: hungry for an answer. Physiology. 2016; 31(2):131-46,
McCowan LM, Figueras F, and Anderson NH. Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy. American journal of obstetrics and gynecology. 2018; 28; 218(2):S855-68.
Tamblyn, Jennifer A, and R. Katie Morris. "Small for gestational age and intrauterine growth restriction." David M. Lusely and Mark D Kilby. Obstetrics & Gynecology an Evidence based text for MRCOG. 3rd edition. Taylor& Francis Group. London UK 2016; 38: 281-88.
Schlaudecker EP, Munoz FM, Bardají A, Boghossian NS, Khalil A, Mousa H, et al. Small for gestational age: Case definition & guidelines for data collection, analysis, and presentation of maternal immunisation safety data. Vaccine, 2017; 35(48):6518-28,
Zhang S, Regnault TR, Barker PL, Botting KJ, McMillen IC, McMillan CM, et al. Placental adaptations in growth restriction. Nutrients, 2015; 7(1):360-89.
Castel, A., Frank, Y. S., Feltner, J., Karp, F. B., Albright, C. M., et al. Monitoring fetal electroencephalogram intrapartum: a systematic literature review. Frontiers in Pediatrics, 2020.
El-Kady M, Hamdy E, Eltaieb E. Role of cerebro-placental ratio in prediction of perinatal outcome in high-risk pregnancies with intrauterine growth restriction. Evidence Based Women's Health Journal. 2020; 10. 162-169. 10.21608/ebwhj.2020.22950.1075.
Bharatnur S, Rani CK, Hebbar S. Study of Cerebro-Placental Ratio in Pregnancies with Abnormal Umbilical Artery Doppler in Predicting Adverse Perinatal Outcome: Are we here yet? J Preg Child Health 2021; 04: 118. DOI: 10.29011/JPCH-118.100018.
Mari G, Hanif F, Kruger M, Cosmi E, Santolaya-Forgas J, Treadwell M. Middle cerebral artery peak systolic velocity: a new Doppler parameter in the assessment of growth restricted fetuses. Ultrasound Obstet Gynecol, 2007; 29: 310–316.
Saha SC, Rai R, Bagga R, Jain A, Mukhopadhyay K, Kumar P. Pregnancy Outcome of Rh D Alloimmunized Pregnancies: A Tertiary Care Institute Experience of a Developing Country. J Obstet Gynaecol India. 2021; 71(6):583-590. doi: 10.1007/s13224-021-01455-4. Epub 2021 Jul 21. PMID: 34898895; PMCID: PMC8617237.
Tolu LB, Ararso R, Abdulkadir A, Feyissa GT, Worku Y. Perinatal outcome of growth restricted fetuses with abnormal umbilical artery Doppler waveforms compared to growth restricted fetuses with normal umbilical artery Doppler waveforms at a tertiary referral hospital in urban Ethiopia. PLoS ONE 2020; 15(6): e0234810.
Contro E, Cha DH, De Maggio I, Ismail SY, Falcone V, Gabrielli S, Farina (2014)A. Uterine artery Doppler longitudinal changes in pregnancies complicated with intrauterine growth restriction without preeclampsia. Prenat Diagn. 2014 Dec;34(13):1332-6. doi: 10.1002/pd.4476. Epub 2014 Aug 27. PMID: 25098960.
El Ktatny HHM, Khaled MA, Mostafa AA. Umbilical and Middle Cerebral Artery Doppler Indices at Late Third Trimester in the Prediction of Perinatal Outcome in Growth Restricted Fetuses The Egyptian Journal of Hospital Medicine (October 2020) Vol. 81 (2), Page 1426-1431 1426 Received: 22 /6 /2020 Accepted:21 /8/2020.
Ebrashy O, Azmy O, Ibrahim M. Middle cerebral umbilical artery resistance index ratio as sensitive parameter for fetal well-being and neonatal outcome in patients with the eclampsia. Case Control Study. Croat J Med J.2005; 46 (5): 826-831.
Bernstein IM, Goran MI, Amini SB, Catalano PM. Differential growth of fetal tissues during the second half of pregnancy. Am J Obstet Gynecol 1997; 176: 28– 32.
Larciprete H, Valensise G, Di Pierro B, Vasapollo B, Casalino D, Arduini S ET AL. Intrauterine growth restriction and fetal body composition, First published, 2005.
Sengodan SS, Mathiyalagan S. Doppler study (cerebroplacental ratio) as a predictor of adverse perinatal outcome. Int J Reprod Contracept Obstet Gynecol 2020; 9:5068-74.
Natthicha C, Chusana P. The relationship between intrapartum cerebroplacental ratio and adverse perinatal outcomes in term fetuses. Eur J Obstet Gynecol Reprod Biol. 2018; 228
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