Relationship of polymorphism of untranslated region (5-UTR) of the insulin-like growth factor (IGF-1) gene with milk production and growth traits in local black goats


  • Ruaa Nasrat Ali Diyala Agriculture Directorate, Ministry of Agriculture, Iraq
  • Zaid Mohammed Mahdi Department of Animal Production/College of Agriculture, University of Diyala, Iraq


IGF-1 gene, milk production, growth traits, local goats


             The study was conducted on a sample of 34 local goats in a private field of a breeder in Canaan sub-district / Diyala governorate. Laboratory work was conducted in the laboratory of the College of Agriculture - University of Diyala and the Office of Scientific Advancement - Al-Harithiya – Baghdad- Iraq for the period from 13/11/2021 to 1/5/ 2022 with aim of studying the genetic polymprphism of the untranslated region (5-UTR) of the IGF-1 gene and its relationship to milk traits (daily milk production - DMY and total milk production - TMY)  and growth traits (birth weight -BWT, weaning weight -WWT and weight gain pre-weaning-WG). The results of the study showed a highly significant (P < 0.01) between the genotypes, as two genotypes of  5-UTR were observed, namely, GG and AG, with frequency distribution ratios of 91% and 9%, respectively, while the frequency of the G allele was more) 94%) compared frequency A allele (6%) in the studied sample. 


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Al Jalili, Zuhair Fakhri, Jalal Elia Alqas. (1984). Sheep and goats production. Ministry of Higher Education and Scientific Research, Institution of Technical Institutes. Iraqi Republic.

Alqas, Jalal Elia, Zuhair Fakhri Al Chalabi and Aziz, Daeb Ishaq. (1993). Basics of sheep and goat production and breeding, College of Agriculture, University of Baghdad, Dar Al-Kutub Press for Printing and Publishing.

Al-Azzawi, Saleh Hassan. (2017). Genetic analysis of milk production and length of milk season for Shami goats under semi-intensive breeding conditions in central Iraq. Diyala District for Agricultural Sciences 9 (special issue): 16-24.

Jayed, Talib Ahmed, Muntaha Yaqoub Yousef, Bashar Faleh Zughair, Jaafar Muhammad Owaid.( 2011). Genetic morphology of the iron-to-blood protein transferrin (transferrin) in Arab sheep. Diyala Journal of Agricultural Sciences. 3(2): 69-76.

Bayraktar, M., & Shoshin, O. 2021. Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep. Brazilian Archives of Biology and Technology, 64.

Deng, C., Ma, R., Yue, X., Lan, X., Chen, H., & Lei, C.( 2010). Association of IGF-I gene polymorphisms with milk yield and body size in Chinese dairy goats. Genetics and molecular biology, 33, 266-270.

Di Stefano, M. V.(2017). IGF-I and its role in dairy animals: investigations on Holstein Friesian cows and Sarda sheep. IGF-I and its role in dairy animals: investigations on Holstein Friesian cows and Sarda sheep, 78.

Estany, J., Tor, M., Villalba, D., Bosch, L., Gallardo D., Jimenez, N. L., Altet, Noguera, J.L., Reixach, J., Amills, M. and Sanchez, A. (2007). Association of CA repeat polymorphism at intron 1 of insulin-like growth factor (IGF-I) gene with circulating IGF-1 concentration, growth and fatness in swine. Physiol. Genomics, 31:236-243.

Ge, W., Davis, M.E., Hines, H.C., Irvin, K.M. and Simmen, R.C. (2001).Association of a genetic marker with blood serum insulin-like growth factor-I concentration and growth traits in Angus cattle. J.Anim Sci., 79: 1757-1762.

Gootwine, E and Pollott, G. E.( 2000). Factors affecting milk production in improved Awassi dairy ewes . Animal Science, 71: 607-615.

Hashizume, T., Ohtsuki, K., and N. Matsumoto. (2000). Serum insulin-like growth factor-Iconcentrations increase during the estrous phase in goats. Domestic Animal Endocrinology. 18: 253-263.

ICAR ,( 2004) . International Committee for milk recording. Milk recording in sheep in ICAR member countries. ICAR , Rome .

Jones, J. I., and D. R. Clemmons. (1995). Insulin-like growth factors and their binding proteins: biological actions, Endocrine Review. 16(1): 3–34.

SAS. (2012). Statistical Analysis System, User's Guide. Statistical. Version 9.1th ed. SAS. Inst. Inc. Cary. N.C. USA.

Sebastiano, L., Consuelo, M. M., Luisa, P., Giovanni, C., Michella, N., & Vincenzo, C. (2020). Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep. Veterinary and Animal Science, 9, 100084.‏

Todd, B. J., Merhi, Z. O., Shu, J., Etgen, A. M., and G. S. Neal-Perry. (2010). Hypothamic insulin-like growth factor-1 receptors are necessary for hormone-dependent luteinizinghormone surges: Implications for female reproductive aging. Endocrinology. 151,449: 1356-1366.

Naicy, T., Venkatachalapathy, T., Aravindakshan, T., Raghavan, K. C., Mini, M., & Shyama, K. (2017). Association of a novel single nucleotide polymorphism at the exon-2 of Insulin-Like Growth Factor 1 (IGF1) gene with phenotypic variants in goats. Veterinarski arhiv, 87(4), 457-472.

Wathes, D. C., Reynolds, T. S., Robinson, R. S., and K. R. Stevenson. (1998). Role of the insulin-like growth factor system in uterine function and placental development in ruminants. Journal of Dairy Science. 81: 1778-1789.

Yurnalis , A. and Putra, D.E. (2017). Polymorphism of Insulin-like Growth Factor 1 Gene (IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia. Pakistan Journal of Biological Sciences,20: 210-216.

Arnawa, I.K., Sapanca, P.L.Y., Martini, L.K.B., Udayana, I.G.B., Suryasa, W. (2019). Food security program towards community food consumption. Journal of Advanced Research in Dynamical and Control Systems, 11(2), 1198-1210.

Gede Budasi, I. & Wayan Suryasa, I. (2021). The cultural view of North Bali community towards Ngidih marriage reflected from its lexicons. Journal of Language and Linguistic Studies, 17(3), 1484–1497

Gandamayu, I. B. M., Antari, N. W. S., & Strisanti, I. A. S. (2022). The level of community compliance in implementing health protocols to prevent the spread of COVID-19. International Journal of Health & Medical Sciences, 5(2), 177-182.



How to Cite

Ali, R. N., & Mahdi, Z. M. (2022). Relationship of polymorphism of untranslated region (5-UTR) of the insulin-like growth factor (IGF-1) gene with milk production and growth traits in local black goats. International Journal of Health Sciences, 6(S3), 12366–12375.



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