Anti-aging herbs for skin: Experimental study on mice
Keywords:
aging, apium graveolens, carthamus tinctorious and punica granatumAbstract
Herbal remedy has been used for beauty and health purposes in the traditional and modern medicine. The range of using herbs has been escalating in the past few years . However, there are no enough scientific based evidence in this aspect, as herbs contain a wide range of phytochemicals that has to be studied in meticulous details to understand its effect on the body. In this study, three plants were chosen from the local Iraqi market and extracted, then a pharmacological study was conducted on mice. Histopathological changes were studied on all the study groups. It was concluded that the three herbal aqueous extracts of ( APIUM GRAVEOLENS, CARTHAMUS TINCTORIOUS AND PUNICA GRANATUM) gave an antiaging effect and was able to reverse aging induced by D- Galactose. PUNICA GRANATUM ( Pomegranate) gave the best result in reversing aging signs on mouse skin.
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Afzal, K., Uzair, Muhammad., Chaudhary, B. A., Ahmad, A., Afzal, S. A. M. I. N. A. and Saadullah, M. (2015). Genus Ruellia: Pharmacological and phytochemical importance in ethnopharmacology. Acta Poloniae Pharmaceutica-Drug Research, 72(5), 821-7.
Liu1,4, Qingxia Wei2,5, Junjun She2, Huaixing Cang1* and Rui Xue ZhangDose Effects of Orally Administered Spirulina Suspension on Colonic Microbiota in Healthy Mice. Front. Cell. Infect. Microbiol., 05 July 2019
Zhang, L. L., Tian, K., Tang, Z. H., Chen, X. J., Bian, Z. X., Wang, Y. T., & Lu, J. J. (2016). Phytochemistry and Pharmacology of Carthamus tinctorius L. The American journal of Chinese medicine, 44(02), 197-226.
Delshad, E., Yousefi, M., Sasannezhad, P., Rakhshandeh, H., & Ayati, Z. (2018). Medical uses of Carthamus tinctorius L.(Safflower): a comprehensive review from traditional medicine to modern medicine. Electronic physician, 10(4), 6672.
Chonpathompikunlert, P., Boonruamkaew, P., Sukketsiri, W., Hutamekalin, P., & Sroyraya, M. (2018). The antioxidant and neurochemical activity of Apium graveolens L. and its ameliorative effect on MPTP-induced Parkinson-like symptoms in mice. BMC Complementary and Alternative Medicine, 18(1), 1-12.
Kooti, W., Mansori, E., Ghasemiboroon, M., Harizi, M., & Amirzarga, A. (2014). Protective effects of celery (Apium Graveolens) on testis and cauda epididymal spermatozoa in rat. International Journal of Reproductive BioMedicine, 12(5), 365-0.
Kooti, W., Mansouri, E., Ghasemiboroon, M., Harizi, M., Ashtary-Larky, D., & Afrisham, R. (2014). The Effects of hydroalcoholic extract of apium graveolens leaf on the number of sexual cells and testicular structure in rat. Jundishapur journal of natural pharmaceutical products, 9(4).
Zeng, X., Guo, F., & Ouyang, D. (2020). A review of the pharmacology and toxicology of aucubin. Fitoterapia, 140, 104443.
Dolati, K., Rakhshandeh, H., Golestani, M., Forouzanfar, F., Sadeghnia, R., & Sadeghnia, H. R. (2018). Inhibitory effects of Apium graveolens on xanthine oxidase activity and serum uric acid levels in hyperuricemic mice. Preventive Nutrition and Food Science, 23(2), 127.
Kodeeswaran Parameshwaran,1 Michael H. Irwin,1 Kosta Steliou,2 and Carl A. Pinkert, D-Galactose Effectiveness in Modeling Aging and Therapeutic Antioxidant Treatment in Mice. 2010 Dec; 13(6): 729–735.
Jafari, M., & Rose, M. R. (2006). Rules for the use of model organisms in antiaging pharmacology. Aging cell, 5(1), 17-22.
Jafari, M., Long, A. D., Mueller, L. D., & Rose, M. R. (2006). The pharmacology of ageing in Drosophila. Current Drug Targets, 7(11), 1479-1483.
Floegel, A., Kim, D. O., Chung, S. J., Koo, S. I., & Chun, O. K. (2011). Comparison of ABTS/DPPH Assays to Measure Antioxidant Capacity in Popular Antioxidant-Rich US Foods. Journal of Food Composition and Analysis, 24(7), 1043–1048.
Finetti, C. (2011). Traditional Knowledge and the Patent System : Two Worlds Apart?. World Patent Information, 33 (1), 58–66.
Rui Zhang,Zhen-Chao Tan, Ke-Cheng Huang, Yan Wen, Xiang-Ying Li, Jun-Long Zhao,and Cheng-Lan Liu (2019). A Vortex-Assisted Dispersive Liquid-Liquid Microextraction Followed by UPLC-MS/MS for Simultaneous Determination of Pesticides and Aflatoxins in Herbal TeaMolecules. 2019 Mar; 24(6): 1029.
Fernando, C. D., & Soysa, P. (2015). Extraction Kinetics of phytochemicals andantioxidant activity during black tea (Camellia sinensis L.) brewing. Nutr J. 2015 Jul 31;14:74
Fadavi, A. (2005). Physicochemical composition of ten pomegranate cultivars (Punica granatum L.) grown in Iran. Revista de Agaroquimicay Tecnologia de Alimentos, 11(2): p. 113-119.
Embuscado, M. E. (2015). Spices and Herbs: Natural Sources of Antioxidants – A Mini Review. Journal of Functional Foods, 18, 811–819.
Collins, J. J., Evason, K., & Kornfeld, K. (2006). Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Experimental gerontology, 41(10), 1032-1039.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
Suryasa, I.W., Sudipa, I.N., Puspani, I.A.M., Netra, I.M. (2019). Translation procedure of happy emotion of english into indonesian in kṛṣṇa text. Journal of Language Teaching and Research, 10(4), 738–746
Gandamayu, I. B. M., Antari, N. W. S., & Strisanti, I. A. S. (2022). The level of community compliance in implementing health protocols to prevent the spread of COVID-19. International Journal of Health & Medical Sciences, 5(2), 177-182. https://doi.org/10.21744/ijhms.v5n2.1897
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