Synthesis and biological evaluation of 3, 4 -dihydropyrimidines thiones derivatives
Keywords:
Dihydropyrimidines, Biginelli, synthesis, antimicrobial, antifungalAbstract
3, 4-dihydropyrimidin-2(1H)-thiones, derivatives were synthesized by one pot solvent free green modified Biginelli cyclocondensation reaction catalyzed by triphenylphosphine as Lewis base. The structures of the synthesized compounds have been elucidated by IR, 1H NMR and elemental analysis. Synthesized compounds were screened for their antimicrobial screened against the E.coli and staphylococcus aureus, Salmonella typhi, Bacillus subtilis, Escherichia coli and antifungal activity against Aspergillus niger, Penecillium crysogenum, Aspergillus flavus, and Candida albicans.
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