Multifunctional management of gold nanoparticles for improved applications
Keywords:
Molecular nanoprobes, imaging, detection of disease, drug delivery, gold nanoparticles, Au NPsAbstract
Increasingly, nanotechnology has the potential to be applied in disease detection or treatment. Nanotechnology advancements have resulted in novel and improved biomedical nanomaterials. Liposomes, polymeric micelles, graphene, carbon nanotubes, quantum dots, ferro ferric oxide nanoparticles, gold nanoparticles (Au NPs), and so on are some of the most commonly used nanomaterials in biomedical applications. Because of its unique optical, electrical, sensing and biological capabilities, Au NPs have been regarded as the most fascinating nanomaterial. Medical imaging, drug administration and tumour therapy are all possible applications of Au NPs in the early identification and diagnosis and treatment of illnesses. This review focuses on some recent breakthroughs in the management of Au NPs as drug carriers for the intracellular delivery of therapies and as molecular nanoprobes for the detection and monitoring of target molecules.
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Akhter, S.; Ahmad, I.; Ahmad, M.Z.; Ramazani, F.; Singh, A.; Rahman, Z.; Kok, R.J. Nanomedicines as cancer therapeutics: Current status. Curr. Cancer Drug Targets 2013, 13, 362–378. [CrossRef] [PubMed]
Verissimo, T.V.; Santos, N.T.; Silva, J.R.; Azevedo, R.B.; Gomes, A.J.; Lunardi, C.N. In vitro cytotoxicity and phototoxicity of surface-modified gold nanoparticles associated with neutral red as a potential drug delivery system in phototherapy. Mater. Sci. Eng. C 2016, 65, 199–204. [CrossRef] [PubMed]
Fratoddi, I.; Venditti, I.; Cametti, C.; Russo, M.V. How toxic are gold nanoparticles? The state-of-the-art. Nano Res. 2015, 8, 1771–1799. [CrossRef]
Hainfeld, J.F.; Slatkin, D.N.; Focella, T.M.; Smilowitz, H.M. Gold nanoparticles: A new X-ray contrast agent. Br. J. Radiol. 2005, 79, 248–253. [CrossRef] [PubMed]
Kumar, A.; Zhang, X.; Liang, X.J. Gold nanoparticles: Emerging paradigm for targeted drug delivery system. Biotechnol. Adv. 2013, 31, 593–606. [CrossRef] [PubMed]
Khalil, I.; Julkapli, N.M.; Yehye, W.A.; Basirun, W.J.; Bhargava, S.K. Graphene-gold nanoparticles hybrid-synthesis, functionalization, and application in a electroc
Wang, C.; Zhang, H.; Zeng, D.; San, L.; Mi, X. DNA nanotechnology mediated gold nanoparticle conjugates and their applications in biomedicine. Chin. J. Chem. 2016, 34, 299–307. [CrossRef]
Razzaque, S.; Hussain, S.Z.; Hussain, I.; Tan, B. Design and utility of metal/metal oxide nanoparticles mediated by thioether end-functionalized polymeric ligands. Polymers 2016, 8, 156. [CrossRef]
Austin, L.A.; Mackey, M.A.; Dreaden, E.C.; El-Sayed, M.A. The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery. Arch. Toxicol. 2014, 88, 1391–1417. [CrossRef] [PubMed]
Frens, G. Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions. Nature 1973, 241, 20–22. [CrossRef]
Nikoobakht, B.; El-Sayed, M.A. Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem. Mater. 2003, 15, 1957–1962. [CrossRef]
Ali, M.R.; Snyder, B.; El-Sayed, M.A. Synthesis and optical properties of small Au nanorods using a seedless growth technique. Langmuir 2012, 28, 9807–9815. [CrossRef] [PubMed]
Saha, B.; Bhattacharya, J.; Mukherjee, A.; Ghosh, A.; Santra, C.; Dasgupta, A.K.; Karmakar, P. In vitro structural and functional evaluation of gold nanoparticles conjugated antibiotics. Nanoscale Res. Lett. 2007, 2, 614–622. [CrossRef]
Gu, H.; Ho, P.L.; Tong, E.; Wang, L.; Xu, B. Presenting vancomycin on nanoparticles to enhance antimicrobial activities. Nano Lett. 2003, 3, 1261–1263. [CrossRef]
Chen, Y.H.; Tsai, C.Y.; Huang, P.Y.; Chang, M.Y.; Cheng, P.C.; Chou, C.H.; Wu, C.L. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol. Pharmaceut. 2007, 4, 713–722. [CrossRef] [PubMed]
Wang, F.; Wang, Y.C.; Dou, S.; Xiong, M.H.; Sun, T.M.; Wang, J. Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano 2011, 5, 3679–3692. [CrossRef] [PubMed]
Brown, S.D.; Nativo, P.; Smith, J.A.; Stirling, D.; Edwards, P.R.; Venugopal, B.; Wheate, N.J. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J. Am. Chem. Soc. 2010, 132, 4678–4684. [CrossRef] [PubMed]
Shenoy, D.; Fu, W.; Li, J.; Crasto, C.; Jones, G.; DiMarzio, C.; Amiji, M. Surface functionalization of gold nanoparticles using hetero-bifunctional poly (ethylene glycol) spacer for intracellular tracking and delivery. Int. J. Nanomed. 2006, 1, 51–57. [CrossRef]
Bhattacharya, R.; Patra, C.R.; Earl, A.; Wang, S.; Katarya, A.; Lu, L.; Mukherjee, P. Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells. Nanomed. Nanotechnol. 2007, 3, 224–238. [CrossRef]
Gu, Y.J.; Cheng, J.; Lin, C.C.; Lam, Y.W.; Cheng, S.H.; Wong, W.T. Nuclear penetration of surface functionalized gold nanoparticles. Toxicol. Appl. Pharmacol. 2009, 237, 196–204. [CrossRef] [PubMed]
Miller, A.D. Human gene therapy comes of age. Nature 1992, 357, 455–460. [CrossRef] [PubMed]
Kim, E.Y.; Schulz, R.; Swantek, P.; Kunstman, K.; Malim, M.H.; Wolinsky, S.M. Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes. Gene Ther. 2012, 19, 347–353. [CrossRef] [PubMed]
McIntosh, C.M.; Esposito, E.A.; Boal, A.K.; Simard, J.M.; Martin, C.T.; Rotello, V.M. Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters. J. Am. Chem. Soc. 2001, 123, 7626–7629. [CrossRef] [PubMed]
Han, G.; Martin, C.T.; Rotello, V.M. Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents. Chem. Biol. Drug Des. 2006, 67, 78–82. [CrossRef] [PubMed]
Rosi, N.L.; Giljohann, D.A.; Thaxton, C.S.; Lytton-Jean, A.K.; Han, M.S.; Mirkin, C.A. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 2006, 312, 1027–1030. [CrossRef] [PubMed]
Bonoiu, A.C.; Mahajan, S.D.; Ding, H.; Roy, I.; Yong, K.T.; Kumar, R.; Prasad, P.N. Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. Proc. Natl. Acad. Sci. USA 2009, 106, 5546–5550. [CrossRef] [PubMed]
Zhao, X.; Huang, Q.; Jin, Y. Gold nanorod delivery of LSD1 siRNA induces human mesenchymal stem cell differentiation. Mater. Sci. Eng. C 2015, 54, 142–149. [CrossRef] [PubMed]
Liu, L.; Li, S.; Liu, L.; Deng, D.; Xia, N. Simple, sensitive and selective detection of dopamine using dithiobis (succinimidylpropionate)-modified gold nanoparticles as colorimetric probes. Analyst 2012, 137, 3794–3799. [CrossRef] [PubMed]
Bhumkar, D.R.; Joshi, H.M.; Sastry, M.; Pokharkar, V.B. Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin. Pharm. Res. 2007, 24, 1415–1426. [CrossRef] [PubMed]
Verma, A.; Simard, J.M.; Worrall, J.W.; Rotello, V.M. Tunable reactivation of nanoparticle-inhibited β-galactosidase by glutathione at intracellular concentrations. J. Am. Chem. Soc. 2004, 126, 13987–13991. [CrossRef] [PubMed]
Schäffler, M.; Sousa, F.; Wenk, A.; Sitia, L.; Hirn, S.; Schleh, C.; Salmona, M. Blood protein coating of gold nanoparticles as potential tool for organ targeting. Biomaterials 2014, 35, 3455–3466. [CrossRef] [PubMed]
Demenev, V.A.; Shchinova, M.A.; Ivanov, L.I.; Vorobeva, R.N.; Zdanovskaia, N.I.; Nebaikina, N.V. Perfection of methodical approaches to designing vaccines against tick-borne encephalitis. Vopr. Virusol. 1996, 41, 107–110. [PubMed]
Xu, L.; Liu, Y.; Chen, Z.; Li, W.; Wang, L.; Wu, X.; Ji, Y.; Zhao, Y.; Ma, L.; Shao, Y.; et al. Surface-engineered gold nanorods: Promising DNA vaccine adjuvant for HIV-1 treatment. Nano Lett. 2012, 12, 2003–2012. [CrossRef] [PubMed]
Shiang, Y.C.; Ou, C.M.; Chen, S.J.; Ou, T.Y.; Lin, H.J.; Huang, C.C.; Chang, H.T. Highly efficient inhibition of human immunodeficiency virus type 1 reverse transcriptase by aptamers functionalized gold nanoparticles. Nanoscale 2013, 5, 2756–2764. [CrossRef] [PubMed]
Liu, Y.; Chen, C. Role of nanotechnology in HIV/AIDS vaccine development. Adv. Drug Deliv. Rev. 2016, 103, 76–89. [CrossRef] [PubMed]
Comber, J.D.; Bamezai, A. Gold nanoparticles (AuNPs): A new frontier in vaccine delivery. J. Nanomed. Biother. Discov. 2015, 5. [CrossRef]
Sun, B.; Xia, T. Nanomaterial-based vaccine adjuvants. J. Mater. Chem. B 2016, 4, 5496–5509. [CrossRef]
Ilinskaya, A.N.; Dobrovolskaia, M.A. Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future. Toxicol. Appl. Pharmacol. 2016, 299, 70–77. [CrossRef] [PubMed]
Dykman, L.A.; Khlebtsov, N.G. Immunological properties of gold nanoparticles. Chem. Sci. 2017, 8, 1719–1735. [CrossRef] [PubMed]
Neto, L.M.M.; Kipnis, A.; Junqueira-Kipnis, A.P. Role of metallic nanoparticles in vaccinology: Implications for infectious disease vaccine development. Front. Immunol. 2017, 8. [CrossRef]
Skirtach, A.G.; Muñoz Javier, A.; Kreft, O.; Köhler, K.; Piera Alberola, A.; Möhwald, H.; Sukhorukov, G.B. Laser-induced release of encapsulated materials inside living cells. Angew. Chem. Int. Ed. 2006, 45, 4612–4617. [CrossRef] [PubMed]
Ghosh, P.; Han, G.; De, M.; Kim, C.K.; Rotello, V.M. Gold nanoparticles in delivery applications. Adv. Drug Delive. Rev. 2008, 60, 1307–1315. [CrossRef] [PubMed]
Gupta, P.; Vermani, K.; Garg, S. Hydrogels: From controlled release to pH-responsive drug delivery. Drug Discov. Today 2002, 7, 569–579. [CrossRef]
Sreejivungsa, K.; Suchaichit, N.; Moosophon, P.; Chompoosor, A. Light-regulated release of entrapped drugs from photoresponsive gold nanoparticles. J. Nanomater. 2016, 2016. [CrossRef]
Wang, D.; Xu, Z.; Yu, H.; Chen, X.; Feng, B.; Cui, Z.; Wang, J. Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods. Biomaterials 2014, 35, 8374–8384. [CrossRef] [PubMed]
Angelatos, A.S.; Radt, B.; Caruso, F. Light-responsive polyelectrolyte/gold nanoparticle microcapsules. J. Phys. Chem. B 2005, 109, 3071–3076. [CrossRef] [PubMed]
Li, W.; Zhang, X.; Zhou, M.; Tian, B.; Yu, C.; Jie, J.; Zhang, X. Functional core/shell drug nanoparticles for highly effective synergistic cancer therapy. Adv. Healthc. Mater. 2014, 3, 1475–1485. [CrossRef] [PubMed]
Park, J.; Park, J.; Ju, E.J.; Park, S.S.; Choi, J.; Lee, J.H.; Kim, C. Multifunctional hollow gold nanoparticles designed for triple combination therapy and CT imaging. J. Control. Release 2015, 207, 77–85. [CrossRef] [PubMed]
Cheng, Y.; C. Samia, A.; Meyers, J.D.; Panagopoulos, I.; Fei, B.; Burda, C. Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer. J. Am. Chem. Soc. 2008, 130, 10643–10647. [CrossRef] [PubMed]
Kawano, T.; Yamagata, M.; Takahashi, H.; Niidome, Y.; Yamada, S.; Katayama, Y.; Niidome, T. Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses. J. Control. Release 2006, 111, 382–389. [CrossRef] [PubMed]
Wu, P.; Hwang, K.; Lan, T.; Lu, Y. A DNAzyme-gold nanoparticle probe for uranyl ion in living cells. J. Am. Chem. Soc. 2013, 135, 5254–5257. [CrossRef] [PubMed]
Guo, Y.; Li, S.; Liu, J.; Yang, G.; Sun, Z.; Wan, J. Double functional aptamer switch probes based on gold nanorods for intracellular ATP detection and targeted drugs transportation. Sens. Actuators B Chem. 2016, 235, 655–662. [CrossRef]
Kong, F.Y.; Xu, M.T.; Xu, J.J.; Chen, H.Y. A novel lable-free electrochemical immunosensor for carcinoembryonic antigen based on gold nanoparticles-thionine-reduced graphene oxide nanocomposite film modified glassy carbon electrode. Talanta 2011, 85, 2620–2625. [CrossRef] [PubMed]
Kong, F.Y.; Xu, M.T.; Xu, J.J.; Chen, H.Y. Gold nanoparticle/DNA/methylene blue nanocomposites for the ultrasensitive electrochemical detection of carcinoembryonic antigen. Electrochim. Acta 2011, 56, 9386–9390. [CrossRef]
Huefner, A.; Septiadi, D.; Wilts, B.D.; Patel, I.I.; Kuan, W.L.; Fragniere, A.; Mahajan, S. Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes. Methods 2014, 68, 354–363. [CrossRef] [PubMed]
Indrasekara, A.S.D.S.; Paladini, B.J.; Naczynski, D.J.; Starovoytov, V.; Moghe, P.V.; Fabris, L. Dimeric gold nanoparticle assemblies as tags for SERS-based cancer detection. Adv. Healthc. Mater. 2013, 2, 1370–1376. [CrossRef] [PubMed]
Xie, W.; Wang, L.; Zhang, Y.; Su, L.; Shen, A.; Tan, J.; Hu, J. Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering. Bioconj. Chem. 2009, 20, 768–773. [CrossRef] [PubMed]
Lee, N.; Choi, S.H.; Hyeon, T. Nano-Sized CT Contrast Agents. Adv. Mater. 2013, 25, 2641–2660. [CrossRef] [PubMed]
Jing, L.; Liang, X.; Deng, Z.; Feng, S.; Li, X.; Huang, M.; Dai, Z. Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer. Biomaterials 2014, 35, 5814–5821. [CrossRef] [PubMed]
Kim, D.; Jeong, Y.Y.; Jon, S. A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 2010, 4, 3689–3696. [CrossRef] [PubMed]
Wang, H.; Zheng, L.; Peng, C.; Guo, R.; Shen, M.; Shi, X.; Zhang, G. Computed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles. Biomaterials 2011, 32, 2979–2988. [CrossRef] [PubMed]
Peng, C.; Zheng, L.; Chen, Q.; Shen, M.; Guo, R.; Wang, H.; Shi, X. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. Biomaterials 2012, 33, 1107–1119. [CrossRef] [PubMed]
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937
Wang, H.; Zheng, L.; Peng, C.; Shen, M.; Shi, X.; Zhang, G. Folic acid-modified dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human lung adencarcinoma. Biomaterials 2013, 34, 470–480. [CrossRef] [PubMed]
Wen, S.; Li, K.; Cai, H.; Chen, Q.; Shen, M.; Huang, Y.; Shi, X. Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging applications. Biomaterials 2013, 34, 1570–1580. [CrossRef] [PubMed]
The effect of reproductive health education with multimedia video learning on the improvement of fluor albus prevention behavior young woman pathologist
Zhang, J.; Li, C.; Zhang, X.; Huo, S.; Jin, S.; An, F.F.; Guo, F. In vivo tumor-targeted dual-modal fluorescence/CT imaging using a nanoprobe co-loaded with an aggregation-induced emission dye and gold nanoparticles. Biomaterials 2015, 42, 103–111. [CrossRef] [PubMed]
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