Assessing the efficacy of parenteral iron therapy in treating pregnancy anemia of mild to moderate severity
A clinical study
Keywords:
anemia, hemoglobin values, iron deficiency anemia, parenteral therapy, pregnant womenAbstract
Background: Anemia is a clinical condition characterized by the decreased number of red blood cells or their capacity to carry oxygen needed for physiological functions. Hemoglobin (Hb) value less than 2 standard deviations, less than the median value for healthy subjects matched for pregnancy status, smoking, altitude, gender, and age. Anemia is commonly seen in pregnancy where intravenous iron has proven to be highly effective as a treatment even in cases where oral iron seems ineffective. Aim: The present study was conducted to assess the efficacy of parenteral iron therapy in treating pregnancy anemia of mild to moderate severity. Materials and methods: The present study included 120 pregnant females having confirmed diagnoses of iron deficiency anemia. All the included subjects were given 100mg Mebendazole in a dose twice daily as an anti-helminthic therapy for 3 days duration. Also, during the therapy, folic acid was given to all the subjects. Stool examination for cyst and ova, urine culture, microscopy, and routine urine examination, Renal function test (RFT) was done for all the subjects. Results: The results of the present study showed that significant changes were seen in various hematologic parameters from baseline to follow-up.
Downloads
References
Khalafallah AA, Hyppa A, Chuang A, Hanna F, Wilson E, Kwok C. A Prospective Randomised Controlled Trial of a Single Intravenous Infusion of Ferric Carboxymaltose vs Single Intravenous Iron Polymaltose or Daily Oral Ferrous Sulphate in the Treatment of Iron Deficiency Anaemia in Pregnancy. Semin Hematol. 2018;55:223-34.
Lindgren S, Wikman O, Befrits R et al. Intravenous iron sucrose is superior to oral iron sulfate for correcting anemia and restoring iron stores in IBD patients: a randomized, controlled, evaluator-blind, multicentre study. Scand J Gastroenterol. 2009;44:838–45.
WHO (2001) Iron deficiency anemia: assessment, prevention, and control. WHO/NHD/01.3, Geneva. World Health Organization, Switzerland
Beutler E, Waalen J. The definition of anemia: what is the lower limit of normal of blood hemoglobin concentration? Blood. 2006;107:1747–50.
Bhavi SB, Jaju PB. Intravenous iron sucrose v/s oral ferrous fumarate for the treatment of anemia in pregnancy. A randomized controlled trial. BMC Pregnancy Childbirth. 2017;17:137.
Froessler B, Gajic T, Dekker G, Hodyl NA. Treatment of iron deficiency and iron-deficiency anemia with intravenous ferric carboxymaltose in pregnancy. Arch Gynecol Obstet. 2018;298:75-82.
Radhika AG, Sharma AK, Perumal V, Sinha A, Sriganesh V, Kulshreshtha V, Kriplani A. Parenteral Versus Oral Iron for Treatment of Iron Deficiency Anaemia During Pregnancy and post-partum: A Systematic Review. J Obstet Gynaecol India. 2019;69:13-24.
Onken JE, Bregman DB, Harrington RA et al. A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia. Transfusion. 2014;54:306–15.
Koutroubakis IE, Oustamanolakis P, Karakoidas C, Mantzaris GJ, Kouroumalis EA. Safety and efficacy of total-dose infusion of low molecular weight iron dextran for iron deficiency anemia in patients with inflammatory bowel disease. Dig Dis Sci. 2010;55:2327–31.
Neeru S, Nair NS, Rai L. Iron sucrose versus oral iron therapy in pregnancy anemia. Indian J Community Med. 2012;37:214-8.
Ermatov, N., Bobomuratov, T., & Sagdullaeva, M. (2022). Prolonged newborns and prolong pregnancy: A modern view on the problem. International Journal of Health & Medical Sciences, 5(1), 26-30. https://doi.org/10.21744/ijhms.v5n1.1829
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
