The toxic effects of bisphenol a (BPA) on some biomarker blood of rats
Keywords:
toxic, bisphenol, biomarker, bloodAbstract
This study was conducted at the College of Science, University of Al-Qadisiyah, to study the relationship between the toxic environmental effects of BPA compound on some biochemical components of the blood of female and male rats. In this study, 60 male and female rats were used, They ranged in age from 8 to 12 weeks, and their weights ranged from 145-200 grams for females and 85-150 grams for males. Rats were divided into four groups according to the dose, with males and females separated. Two control groups: these two groups, three females and three males, dosed 5.0 ml/kg body weight of corn oil per day, group A. Nine females and nine males were fed BPA orally (every day after dissolving in corn oil at 50 mg./kg body weight). Group III (B): 9 females and 9 males were given BPA orally (every day with corn oil, 100 mg/kg body weight). In group C, nine females and nine males were orally injected with a dose of 200 mg/kg BPA dissolved in corn oil every day.
Downloads
References
L. Gossec et al., “European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update,” Ann. Rheum. Dis., vol. 75, no. 3, pp. 499–510, 2016.
W. M. S. Ahmed, W. A. Moselhy, and T. M. Nabil, “Bisphenol A toxicity in adult male rats: hematological, biochemical and histopathological approach.,” Glob. Vet., vol. 14, no. 2, pp. 228–238, 2015.
C. A. Staples, P. B. Dorn, G. M. Klecka, S. T. O’Block, and L. R. Harris, “A review of the environmental fate, effects, and exposures of bisphenol A,” Chemosphere, vol. 36, no. 10, pp. 2149–2173, 1998, doi: 10.1016/S0045-6535(97)10133-3.
C. Bolognesi et al., “Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary,” Efsa J., 2015.
D. Kloukos, N. Pandis, and T. Eliades, “In vivo bisphenol-a release from dental pit and fissure sealants: a systematic review,” J. Dent., vol. 41, no. 8, pp. 659–667, 2013.
J. B. Matthews, K. Twomey, and T. R. Zacharewski, “In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors α and β,” Chem. Res. Toxicol., vol. 14, no. 2, pp. 149–157, 2001.
L. N. Vandenberg, R. Hauser, M. Marcus, N. Olea, and W. V Welshons, “Human exposure to bisphenol A (BPA),” Reprod. Toxicol., vol. 24, no. 2, pp. 139–177, 2007.
S. Biedermann, P. Tschudin, and K. Grob, “Transfer of bisphenol A from thermal printer paper to the skin,” Anal. Bioanal. Chem., vol. 398, no. 1, pp. 571–576, 2010.
L. Reddivari et al., “Perinatal bisphenol A exposure induces chronic inflammation in rabbit offspring via modulation of gut bacteria and their metabolites,” MSystems, vol. 2, no. 5, pp. e00093-17, 2017.
J. R. Rochester, “Bisphenol A and human health: a review of the literature,” Reprod. Toxicol., vol. 42, pp. 132–155, 2013.
P. Alonso-Magdalena, S. Morimoto, C. Ripoll, E. Fuentes, and A. Nadal, “The estrogenic effect of bisphenol A disrupts pancreatic β-cell function in vivo and induces insulin resistance,” Environ. Health Perspect., vol. 114, no. 1, pp. 106–112, 2006.
Marmugi et al., “Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver,” Hepatology, vol. 55, no. 2, pp. 395–407, 2012.
Marmugi et al., “Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice,” Toxicology, vol. 325, pp. 133–143, 2014.
Z. K. Hassan et al., “Bisphenol A induces hepatotoxicity through oxidative stress in rat model,” Oxid. Med. Cell. Longev., vol. 2012, 2012.
W. M. Abdel-Wahab, “Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats.,” Pak. J. Biol. Sci., vol. 17, no. 11, pp. 1152–1160, 2014.
E. R. Ashwood and C. A. Burtis, Tietz textbook of clinical chemistry. WB Saunders, 1999.
C. Winterbourn, R. E. Hawkins, M. Brian, and R. W. Carrell, “The estimation of red cell superoxide dismutase activity,” J. Lab. Clin. Med., vol. 85, no. 2, pp. 337–341, 1975.
H. Aebi, “Catalase,” in Methods of enzymatic analysis, Elsevier, 1974, pp. 673–684.
S. Mueller, H.-D. Riedel, and W. Stremmel, “Determination of catalase activity at physiological hydrogen peroxide concentrations,” Anal. Biochem., vol. 245, no. 1, pp. 55–60, 1997.
J. Seadlak and R. H. Lindsay, “Analytical Biochemistry. 192, Cited by Al-Zamyle, OM, Al-Nimer MS, Al-Muslih RK (2001). Detection the levelof peroxynitrite and related with antioxidant satus in the serum of patients with acute myocardial ifraction,” Nation. J. Chem, vol. 4, pp. 625–637, 1968.
S. Reitman and S. Frankel, “Determination of glutamate pyruvat transaminase and glutamate oxaloacetate transaminase,” Amer. J. Clin. Path, vol. 28, pp. 56–63, 1957.
Belfield and D. M. Goldberg, “Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine,” Enzyme, vol. 12, pp. 561–573, 1971.
P. R. N. Kind and E. King, “Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine,” J. Clin. Pathol., vol. 7, no. 4, p. 322, 1954.
Y. Aristiawan, N. Aryana, D. Putri, and D. Styarini, “Analytical method development for bisphenol a in tuna by using high performance liquid chromatography-UV,” Procedia Chem., vol. 16, pp. 202–208, 2015.
H. Kamel, M. A. Foaud, and H. M. Moussa, “The adverse effects of bisphenol A on male albino rats,” J. Basic Appl. Zool., vol. 79, no. 1, pp. 1–9, 2018.
T. Ozaydın, Y. Oznurlu, E. Sur, I. Celik, D. Uluısık, and M. O. Dayan, “Effects of bisphenol A on antioxidant system and lipid profile in rats,” Biotech. Histochem., vol. 93, no. 4, pp. 231–238, 2018.
M. Koruk, S. Taysi, M. C. Savas, O. Yilmaz, F. Akcay, and M. Karakok, “Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis,” Ann. Clin. Lab. Sci., vol. 34, no. 1, pp. 57–62, 2004.
C.-D. Zhan, R. K. Sindhu, J. Pang, A. Ehdaie, and N. D. Vaziri, “Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet,” J. Hypertens., vol. 22, no. 10, pp. 2025–2033, 2004.
S. B. Nimse and D. Pal, “Free radicals, natural antioxidants, and their reaction mechanisms,” RSC Adv., vol. 5, no. 35, pp. 27986–28006, 2015.
K. P. Steckiewicz et al., “Shape-Depended Biological Properties of Ag3PO4 Microparticles: Evaluation of Antimicrobial Properties and Cytotoxicity in In Vitro Model—Safety Assessment of Potential Clinical Usage,” Oxid. Med. Cell. Longev., vol. 2019, 2019.
V. Bindhumol, K. C. Chitra, and P. P. Mathur, “Bisphenol A induces reactive oxygen species generation in the liver of male rats,” Toxicology, vol. 188, no. 2–3, pp. 117–124, 2003.
A. Korkmaz, M. A. Ahbab, D. Kolankaya, and N. Barlas, “Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats,” Food Chem. Toxicol., vol. 48, no. 10, pp. 2865–2871, 2010.
Y. Sun et al., “Protective effect of metformin on BPA-induced liver toxicity in rats through upregulation of cystathionine β synthase and cystathionine γ lyase expression,” Sci. Total Environ., vol. 750, p. 141685, 2021.
S. E. Elswefy, F. R. Abdallah, H. H. Atteia, A. S. Wahba, and R. A. Hasan, “Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A‐induced liver fibrosis in male rats,” Int. J. Exp. Pathol., vol. 97, no. 5, pp. 369–379, 2016.
S. Khan et al., “Mitochondrial dysfunction induced by Bisphenol A is a factor of its hepatotoxicity in rats,” Environ. Toxicol., vol. 31, no. 12, pp. 1922–1934, 2016.
S. T. B. Kazmi et al., “Quercus dilatata Lindl. ex Royle ameliorates BPA induced hepatotoxicity in Sprague Dawley rats,” Biomed. Pharmacother., vol. 102, pp. 728–738, 2018.
Gede Budasi, I. & Wayan Suryasa, I. (2021). The cultural view of North Bali community towards Ngidih marriage reflected from its lexicons. Journal of Language and Linguistic Studies, 17(3), 1484–1497
Suryasa, W., Sudipa, I. N., Puspani, I. A. M., & Netra, I. (2019). Towards a Change of Emotion in Translation of Kṛṣṇa Text. Journal of Advanced Research in Dynamical and Control Systems, 11(2), 1221-1231.
Khidoyatova, M. R., Kayumov, U. K., Inoyatova, F. K., Fozilov, K. G., Khamidullaeva, G. A., & Eshpulatov, A. S. (2022). Clinical status of patients with coronary artery disease post COVID-19. International Journal of Health & Medical Sciences, 5(1), 137-144. https://doi.org/10.21744/ijhms.v5n1.1858
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
