Benzimidazole-Urea derivatives as anti-cancer agents
In-silico study, synthesis and in-vitro evaluation
Keywords:
Benzimidazole, Urea, Lipinski’s rule, OSIRIS property explorer, Pre ADMET, Antiproliferative activity, T.E.S.T toolAbstract
A new series of urea derivatives containing benzimidazole group as potential anticancer agents have been designed and synthesized. The structures of the synthesized compounds were characterized and confirmed by spectroscopic techniques such as 1H NMR, and Mass spectrometry. A new series of urea derivatives containing benzimidazole group were design with an intention to search new antiproliferative lead compound. Drug like properties and bioactivity score for drug targets of designed compounds were calculated by molinspiration tool and obtained result found to obey Lipinski’s rule that indicates the compound are orally active molecules. Osiris property explorer was used for the prediction of drug relevant properties and toxicity of synthetic compounds. Pre ADMET server was also used to estimate ADME properties of synthetic compounds, results showed good to notable anticancer activity. So that, these new benzimidazole-urea compounds could serve as potential template to become leads in near future for the discovery and development of new effect orally drugs molecules.
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