Acute kidney injury profile of COVID-19 patients and associated risk factors a rural hospital-based retrospective study from Vadodara, Gujarat

Nidhi Vaghani; Apurvakumar Pandya; Ankita Priyadarshini; Hemantkumar Patadia

doi:10.53730/ijhs.v6nS6.9800

Authors

Nidhi Vaghani M.Sc. MLT, Department of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara-391760, Gujarat, India
Apurvakumar Pandya Director, Parul Institute of Public Health, Faculty of Medicine, Parul University, Vadodara-391760, Gujarat, India
Ankita Priyadarshini PhD Scholar, Department of Microbiology, Faculty of Applied Sciences, Parul University, Vadodara -391760, Gujarat, India | Assistant Professor, Department of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara -391760, Gujarat, India
Hemantkumar Patadia
hemantsp87@gmail.com
Assistant Professor, Department of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara -391760, Gujarat, India

Keywords:

acute kidney injury, COVID-19, mortality, gujarat

Abstract

Background: Clinical outcome of patients hospitalized with COVID-19 and acute kidney injury (AKI) are not well understood. The clinical significance of abnormal electrolytes and renal outcome in COVID-19 patients have been poorly documented. We aim to exhibit the electrolyte abnormalities, renal outcome and associated risk factors in hospitalized COVID-19 patients in rural tertiary care hospital in Vadodara district, Western India. Method: A hospital record based retrospective study was conducted. Total 994 patients hospitalized with COVID-19 between 1st April 2021 to 30th June 2021 and those meeting inclusion criteria were included for the analysis. The laboratory data of interest included electrolytes reports like Na⁺, K⁺, CL^-, creatinine and blood urea. Result: Of the total hospitalized COVID-19 patients, 324 patients were eligible. For the criteria for suspected AKI - 279 (86.11%) and no AKI - 45 (13.88%) patients were found. Suspected AKI patients were classified into four conditions: 1) HYPERNATREMIA (14.33%); HYPERKALEMIA (2.15%); BCR ratio >20 (65.59%); HIGH Cl^- (17.92%). Out of total AKI patients, (36.91%) died whereas (13.3%) patients died in no AKI group. All patients were provided antibiotics, steroids and anti-viral therapies irrespective of AKI status, which we presume might have contributed in high mortality among suspected AKI.

Downloads

Download data is not yet available.

References

Kustina, K.T., Dewi, G.A.A.O., Prena, G.D., Suryasa, W. (2019). Branchless banking, third-party funds, and profitability evidence reference to banking sector in indonesia. Journal of Advanced Research in Dynamical and Control Systems, 11(2), 290-299.

Nyandra, M., Kartiko, B.H., Susanto, P.C., Supriyati, A., Suryasa, W. (2018). Education and training improve quality of life and decrease depression score in elderly population. Eurasian Journal of Analytical Chemistry, 13(2), 371-377.

Herman, H., Ardani, I. G. A. I., Aryani, L. N. A., Windiani, I. G. A. T., Adnyana, I. G. N. S., & Setiawati, Y. (2022). Signs and symptoms of depression in children and adolescents with type 1 diabetes mellitus: A case report. International Journal of Health & Medical Sciences, 5(1), 150-153. https://doi.org/10.21744/ijhms.v5n1.1861

Hirsch JS, Ng JH, Ross DW, Sharma P, Shah HH, Barnett RL, et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int. 2020;98(1):209–18.

Robbins-Juarez SY, Qian L, King KL, Stevens JS, Husain SA, Radhakrishnan J, et al. Outcomes for Patients With COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis. Kidney Int Reports. 2020;5(8):1149–60.

Kurts C, Panzer U, Anders H, Rees AJ. The immune system and kidney disease : basic concepts and clinical implications. 2013;(September).

Gao XP, Zheng CF, Liao MQ, He H, Liu YH, Jing CX, et al. Admission serum sodium and potassium levels predict survival among critically ill patients with acute kidney injury: A cohort study. BMC Nephrol. 2019;20(1):1–10.

Original A, Cohort R, Thalji SZ, Kothari AN, Kuo PC, Michael J. HHS Public Access. 2018;266(2):376–82.

Kolhe N V., Fluck RJ, Selby NM, Taal MW. Acute kidney injury associated with COVID-19: A retrospective cohort study. PLoS Med. 2020;17(10):1–16.

Guan WJ, Liang WH, He JX, Zhong NS. Cardiovascular comorbidity and its impact on patients with COVID-19. Eur Respir J. 2020;55(6):1069–76.

Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829–38.

Mohamed MMB, Lukitsch I, Torres-ortiz AE, Walker JB, Varghese V. Acute Kidney Injury Associated with Coronavirus Disease 2019 in Urban New Orleans. 2020;

Sun D, Wang T, Zheng KI. Subclinical Acute Kidney Injury in COVID-19 Patients : A Retrospective Cohort Study. 2020;325000(2).

Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019 : retrospective study. 2019;2.

Sharma PK, Aggarwal V, Sapariya N, Baweja S, Nagori R, Chabbra MK. Renal profile of COVID-19 infected patients admitted in a tertiary care hospital in Western Rajasthan. Int Surg J. 2020;7(7):2332.

Zahid U, Ramachandran P, Spitalewitz S, Alasadi L, Chakraborti A, Azhar M, et al. Acute Kidney Injury in COVID-19 Patients: An Inner City Hospital Experience and Policy Implications. Am J Nephrol. 2020;51(10):786–96.

Rudnick MR, Hilburg R. Acute Kidney Injury in COVID-19: Another Challenge for Nephrology. Am J Nephrol. 2020;51(10):761–3.

Gok M, Cetinkaya H, Kandemir T, Karahan E, Burak İ. Chronic kidney disease predicts poor outcomes of COVID‑19 patients. 2021;1891–8.