8- Hydroxy -deoxyguanosine (8-OHdG) urine as a biomarker of oxidative damage in early elderly hypertension
Keywords:
hypertension, aging, urinary 8-OHdG, oxidative stressAbstract
According to JNC VII, patients with hypertension are patients who clinically have systolic and diastolic blood pressure ≥140 mmHg and ≥90 mmHg, respectively. The aging processes in hypertension are stiffening of the blood vessels and decreasing arterial flexibility. The underlying pathomechanism is oxidative stress due to reactive oxygen species (ROS) elevation. 8-Hydroxy-Deoxyguanosine (8-OHdG) is an oxidized product of DNA repair as a kind of oxidative stress biomarker. This study aimed to analyze urinary 8-OHdG in hypertensive patients and healthy control aged 46-55 years old by involveing 80 participants. Questionnaires and medical records were collected to obtain relevant clinical data. The level of 8-OHdG is measured by the Enzyme-Linked Immunosorbent Assay (ELISA). The results showed that there is no difference in the average urinary level of urinary 8-OHdG of hypertensive patients (1.871 ± 0.689 ng/mL) with the healthy controls (1.743 ± 0.364 ng/mL).
Downloads
References
Nyandra, M., Suryasa, W. (2018). Holistic approach to help sexual dysfunction. Eurasian Journal of Analytical Chemistry, 13(3), pp. 207–212.
Rinartha, K., & Suryasa, W. (2017). Comparative study for better result on query suggestion of article searching with MySQL pattern matching and Jaccard similarity. In 2017 5th International Conference on Cyber and IT Service Management (CITSM) (pp. 1-4). IEEE.
Salawali, A. Q. ., Tahir, A. M. ., & Hardjo, M. . (2021). The effect of family education on the fulfillment of family health tasks in handling case of hypertension post earthquake in Sigi regency. International Journal of Health & Medical Sciences, 4(1), 136-140. https://doi.org/10.31295/ijhms.v4n1.1625
Sugihantono A. Strategi Operasional Pencegahan Dan Pengendalian Penyakit Menuju Cakupan Kesehatan Semesta. In: Rakontek P2p Provinsi Sulawesi Selatan. Makassar: Dirjen Pencegahan Dan Pengendalian Penyakit KEMENKES RI; 2019.
Ansar J, Dwinata I MA. Determinan Kejadian Hipertensi Pada Pengunjung Posbindu Di Wilayah Kerja Puskesmas Ballaparang Kota Makassar. J Nas Ilmu Kesehat. 2019;1(3):28–35.
Higashi Y, Kihara Y, Noma K. Endothelial Dysfunction And Hypertension In Aging. Hypertens Res [Internet]. 2012;35(11):1039–47. Available From: Http://Dx.Doi.Org/10.1038/Hr.2012.138
[European Standards Committee On Ur, Evans MD, Olinski R, Loft S, Cooke MS. Toward Consensus In The Analysis Of Urinary 8‐Oxo‐7,8‐Dihydro‐2′‐Deoxyguanosine As A Noninvasive Biomarker Of Oxidative Stress. FASEB J. 2010;24(4):1249–60.
Roselló-Lletí E, De Burgos FG, Morillas P, Cortés R, Martínez-Dolz L, Almenar L, Et Al. Impact Of Cardiovascular Risk Factors And Inflammatory Status On Urinary 8-Ohdg In Essential Hypertension. Am J Hypertens [Internet]. 2012;25(2):236–42.
Felicya RH. Diagnosis And Management Of Hypertension In The Ederly Patient. J Major [Internet]. 2014;3(2):46–51.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The Hallmarks Of Aging Europe PMC Funders Group. Cell [Internet]. 2013;153(6):1194–217. Available From: Https://Www.Ncbi.Nlm.Nih.Gov/Pmc/Articles/PMC3836174/Pdf/Emss-55354.Pdf
Kusumawaty J, Hidayat N, Ginanjar E. Hubungan Jenis Kelamin Dengan Intensitas Hipertensi Pada Lansia Di Wilayah Factors Related Events Sex With Hypertension In Elderly Work Area Health District Lakbok Ciamis. J Mutiara Med. 2016;16(2):46–51.
Nieuwenhuis-Mark RE. Healthy Aging As Disease? Front Aging Neurosci. 2011;3(FEB):1–1.
Peningkatan T, Dan P, Pada S. Efektivitas Cepat Tensi (Cegah Dan Pantau Hipertensi) Terhadap Peningkatan Pengetahuan Dan Sikap Pada Wanita Menopause. J Heal Educ. 2017;2(2):107–14.
Wirakhmi IN, Purnawan I. Hubungan Kepatuhan Minum Obat Dengan Tekanan Darah Pada Penderita Hipertensi. J Ilmu Keperawatan Dan Kebidanan. 2021;12(2):327.
Girirajan S, Campbell C, Eichler E. 乳鼠心肌提取 HHS Public Access. Vol. 176, Physiology & Behavior. 2011. 139–148 P.
Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Testa G, Et Al. Oxidative Stress And Diseases. Oxidative Stress Dis. 2012;757–72.
Tanjoto EA, Suhartono E. Literature Review: Korelasi Stres Okidatif Dengan Tekenan Darah Pada Lanjut Usia. Homeostasis. 2021;4(1):227–36.
Dinh QN, Drummond GR, Sobey CG, Chrissobolis S. Roles Of Inflammation, Oxidative Stress, And Vascular Dysfunction In Hypertension. Biomed Res Int. 2014.
González J. Essential Hypertension And Oxidative Stress: New Insights. World J Cardiol. 2014;6(6):353.
Singh S, Shankar R, Singh GP. Prevalence And Associated Risk Factors Of Hypertension : A Cross-Sectional Study In Urban Varanasi. 2017.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
