Modulation of solubility and development of a formulation of Plumbagin using hydrotropic solubilization technique

Amrita Thakur; D. K. Tripathi; Hemant Badwaik; Kartik Nakhate

doi:10.53730/ijhs.v6nS5.10071

Authors

Amrita Thakur
amritathakur01@gmail.com
Rungta College of Pharmaceutical Sciences & Research, Rungta Educational Campus, Khoka- Kurud Road, Bhilai, Chhattisgarh 490024 Bhilai (C.G.), and School of Pharmacy, Vishwakarma University, Survey No 2, 3,4, Kondhwa Rd, Laxmi Nagar, Betal Nagar, Kondhwa, Pune, Maharashtra 411048, Pune (M.H.)
D.K. Tripathi Rungta College of Pharmaceutical Sciences & Research, Rungta Educational Campus, Khoka- Kurud Road, Bhilai, Chhattisgarh 490024 Bhilai (C.G.)
Hemant Badwaik Shri Shankaracharya Institute of Pharmaceutical Science, Junwani, Bhilai, Distt. Durg Chhattisgarh- 490020, Bhilai (C.G.)
Kartik Nakhate Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Survey No. 499, Plot No 03, Mumbai - Agra National Hwy, behind Gurudwara, Samta Nagar, Dhule, Maharashtra 424001 Dhule (M.H.)

Keywords:

Hydrotropic agent, solubilization technique, refractive index, solubility

Abstract

The present work aimed to increase the solubility of poorly water-soluble drug plumbagin using the hydrotropic solubilization technique. Plumbagin is a potent natural product extracted from the plant Plumbago zeylanica L. belonging to the family Plumbaginacea. It can be used to treat rheumatoid arthritis, dysmenorrhea, injury, and cancer. An oral liquid syrup was prepared using caffeine as a hydrotropic agent. The results showed 97 folds increase in the solubility of the plumbagin when caffeine was used as a hydrotropic agent. Moreover, various evaluation tests like pH, refractive index determination, and drug content of the developed syrup were performed. All the results showed satisfactory outcomes and proved that it is possible to create a stable dosage form using the hydrotropic solubilization technique.

Downloads

Download data is not yet available.

References

Ahmad, Iftekhar, Pharkphoom Panichayupakaranant, Md Iftekhar Ahmad, P Panichayupakaranant, and Á. M. I. Ahmad. 2016. “Plumbagin and Its Role in Chronic Diseases.” Springer 929:229–46. doi: 10.1007/978-3-319-41342-6_10.

Amidon, GL, H. Lennernäs, VP Shah, JR Crison-Pharmaceutical research, and undefined 1995. n.d. “A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability.” Springer.

Anon. n.d. “Pharmaceutical Practical Guide: Evaluation of Ointments.”

Badwan, A. A., L. K. El-Khordagui, A. M. Saleh, and S. A. Khalil. 1982. “The Solubility of Benzodiazepines in Sodium Salicylate Solution and a Proposed Mechanism for Hydrotropic Solubilization.” International Journal of Pharmaceutics 13(1):67–74. doi: 10.1016/0378-5173(82)90143-0.

Chen, Xiaonan, and J. C. Micheau. 2002. “Hydrotrope-Induced Autocatalysis in the Biphasic Alkaline Hydrolysis of Aromatic Esters.” Journal of Colloid and Interface Science 249(1):172–79. doi: 10.1006/JCIS.2002.8226.

Dharmendira Kumar, M., and N. Nagendra Gandhi. 2000. “Effect of Hydrotropes on Solubility and Mass Transfer Coefficient of Methyl Salicylate.” Journal of Chemical & Engineering Data 45(3):419–23. doi: 10.1021/je9901740.

Domb, Abraham, and Wahid Khan. 2013. Biodegradable Polymers as Drug Carrier Systems.

Friberg, Stig E. 1997. “Hydrotropes.” Current Opinion in Colloid & Interface Science 2(5):490–94. doi: https://doi.org/10.1016/S1359-0294(97)80096-9.

Gurumurthaih, S. S., Prabhakar Yadav, Deepak Gondkar, G. B. Shivakumara, and G. L. Prabhushankar. 2013. “Preparation and Evaluation of Sparfloxacin Parenteral Dosage Form.” 2(1):1–12.

Khan, Iqrar Ahmad, Ahmad Jahan Khanam, Mohmad Shafi Sheikh, and Kabir-ud-Din. 2011. “Influence of Ionic and Nonionic Hydrotropes on Micellar Behavior of a Cationic Gemini Surfactant Butanediyl-1,4-Bis(Dimethylcetylammonium Bromide).” Journal of Colloid and Interface Science 359(2):467–73. doi: 10.1016/J.JCIS.2011.03.083.

Liu, Yuling, Yuee Cai, Chengwei He, Meiwan Chen, and Hui Li. 2017. “Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review.” American Journal of Chinese Medicine 45(3):423–41. doi: 10.1142/S0192415X17500264.

Maheshwari, R. K., and R. Rajagopalan. 2012. “Formulation and Evaluation of Paracetamol Syrup Made by Mixed Solvency Concept.” Der Pharmacia Lettre 4(1):170–74.

Rakhmonov, O. M., Shadmanov, A. K., & Juraev, F. M. (2021). Results of endoscopic treatment of benign prostatic hyperplasia in patients with metabolic syndrome. International Journal of Health & Medical Sciences, 5(1), 21-25. https://doi.org/10.21744/ijhms.v5n1.1811

Maheshwari, Yash, D. K. Mishra, S. C. Mahajan, Prachi Maheshwari, R. K. Maheshwari, V. Jain, and Behind Air Strip. 2013. “Formulation Development of Syrups ( Liquid Oral Solutions ) Of.” 3(4):753–58.

Padhye, Subhash, Prasad Dandawate, Mujahid Yusufi, Aamir Ahmad, and Fazlul H. Sarkar. 2012. “Perspectives on Medicinal Properties of Plumbagin and Its Analogs.” Medicinal Research Reviews 32(6):1131–58. doi: 10.1002/MED.20235.

Pande, Vishal V. 2016. “Exploration of Mixed Hydrotropy Strategy in Formulation and Development of Etodolac Injection.” Journal of Nanomedicine Research 3(4). doi: 10.15406/jnmr.2016.03.00063.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937

Salvia-Trujillo, Laura, Robert Soliva-Fortuny, M. Alejandra Rojas-Graü, D. Julian McClements, and Olga Martín-Belloso. 2017. “Edible Nanoemulsions as Carriers of Active Ingredients: A Review.” Annual Review of Food Science and Technology 8:439–66. doi: 10.1146/ANNUREV-FOOD-030216-025908.

Varade, Dharmesh, and Pratap Bahadur. 2004. “Effect of Hydrotropes on the Aqueous Solution Behavior of Surfactants.” Journal of Surfactants and Detergents 7(3):257–61. doi: 10.1007/s11743-004-0309-7.

Wang, X., Y. Jiang, YW Wang, MT Huang, CT Ho-Food Chemistry, and undefined 2008. n.d. “Enhancing Anti-Inflammation Activity of Curcumin through O/W Nanoemulsions.” Elsevier.