Effect of fenofibrate in comparison to metformin on the biophysical and biochemical parameters in diabetic albino wistar rats

Suhasini Padugupati; S. Ramamoorthy; Kumar Thangavelu; DVHS Sarma; Deepak Jamadar

doi:10.53730/ijhs.v6nS6.10100

Authors

Suhasini Padugupati
drduhasinimd@gmail.com
Research Scholar Department of Biochemistry, Manipal Academy of Higher Education, Manipal, Karnataka, India
S. Ramamoorthy Chief Executive Officer, Department of Toxicology, Palamur Bioscience Pvt.Ltd, Mahabub Nagar, Telangana, India
Kumar Thangavelu Director, Department of Toxicology, Palamur Bioscience Pvt.Ltd, Mahabub Nagar, Telangana, India
DVHS Sarma Professor and Head, Department of Biochemistry, S.V.S Medical College, Mahabub Nagar, Telangana, India
Deepak Jamadar Statistician Cum Assistant Professor, Department of Community Medicine, Palamur Bioscience Pvt.Ltd, Mahabub Nagar, Telangana, India

Keywords:

Feno fibrate (FF), Metformin (Met), Streptozotocin (STZ), Biophysical parameters, Biochemical parameters

Abstract

Introduction: Diabetic endothelial dysfunction is accompanied by increased oxidative stress and upregulated proinflammatory and inflammatory mediators in the endothelial vasculature. Activation of peroxisome proliferator-activated receptor-alpha (PPAR-α) results in antioxidant and anti-inflammatory effects. Aim of this study is to investigate the effect of fenofibrate, a PPAR-α activator, on the oxidative stress, inflammation and its anti-oxidant effect in streptozotocin diabetic rats and to compare the effectiveness of FF with that of Metformin (Met). Material & Methods: This experimental animal study was conducted at animal house. The sample size included 174 albino wistar rats divided into 3 Groups, one control groups (C )Diabetic and untreated and two test groups .T1 -Diabetic and treated with metformin 75 mg/kgwt/day) and T2 (T – Diabetics treated with fenofibrate 100 mg/kgwt/day), with 58 rats in each group (29 male & 29 female). All the rats were treated with streptozotocin intra peritoneally and the diabetic state was induced. T1 group was treated with metformin 75 mg/kg/wt/day. The T2 group of rats were treated with Feno fibrate (FF) at a dose of 100 mg/kgwt/day.

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