Formulation and characterization of Wrightia Tinctoria loaded zinc oxide nanoparticles by green synthesis

Jeremiah Immanuel; N. Damodharan; Bheemireddy Naga Rajesh Reddy

doi:10.53730/ijhs.v6nS4.10160

Authors

Jeremiah Immanuel Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Chennai-603203, Tamilnadu, India
N. Damodharan
damodhan@srmist.edu.in
Head of Department, Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Chennai-603203, Tamilnadu, India
Bheemireddy Naga Rajesh Reddy Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Chennai-603203, Tamilnadu, India

Keywords:

formulation, characterization, Wrightia Tinctoria, zinc oxide nanoparticles, green synthesis

Abstract

In the recent years, nanotechnology has become an important research field of modern material sciences. Green synthesis has garnered wide interest due to its inherent features like rapidity, eco-friendly and cost effectiveness. Zinc oxide nanoparticles were synthesized using Wrightia Tinctoria leaf extract using sol-gel method. The formation of Zinc oxide nanoparticles is confirmed by FTIR. The characterization of the formulated nanoparticles was done by X-ray diffraction (XRD) studies showed the crystalline nature and revealed the purity of Zinc oxide nanoparticles. The morphological studies Transmission electron microscopic (TEM) the shape of the nanoparticles can be identified. The zinc oxide nanoparticles were found to be rod-shaped on Scanning Electron Microscopy (SEM). The in-vitro antibacterial activity showed that the Wrightia tinctoria loaded zinc oxide nanoparticles were found to act against both gram-positive and gram-negative bacteria.

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References

Aiyambo, D. (2010). Traditional uses of selected members of the Apocynaceae family in Namibia. Ministry of Agriculture, Water and Forestry, Windhock.

Al-Daihan, S., & Bhat, R. S. (2012). Antibacterial activities of extracts of leaf, fruit, seed and bark of Phoenix dactylifera. African Journal of Biotechnology, 11(42), 10021–10025.

Anand, U., Nandy, S., Mundhra, A., Das, N., Kumar, P. D., & Dey, A. (2020). Investigation on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from the plant family of Apocynaceae; possible therapeutic approaches against multidrug resistance in pathogenic microorganisms. Drug Resistance Updates.

Bennis, S., Chapey, C., Robert, J., & Couvreur, P. (1994). Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture. European Journal of Cancer, 30(1), 89–93.

Bhuyan, T., Mishra, K., Khanuja, M., Prasad, R., & Varma, A. (2015). Biosynthesis of zinc oxide nanoparticles from Azadirachta indica for antibacterial and photocatalytic applications. Materials Science in Semiconductor Processing, 32, 55–61.

Franci, G., Falanga, A., Galdiero, S., Palomba, L., Rai, M., Morelli, G., & Galdiero, M. (2015). Silver nanoparticles as potential antibacterial agents. Molecules, 20(5), 8856–8874.

Frederickson, C. J., Koh, J.-Y., & Bush, A. I. (2005). The neurobiology of zinc in health and disease. Nature Reviews Neuroscience, 6(6), 449–462.

Kardina, I., Ramadany, S., Sanusi B, Y., Made, S., Stang, S., & Syarif, S. (2020). Children’s midwifery learning media application about android-based rough motor development in improving midwifery student skills. International Journal of Health & Medical Sciences, 3(1), 146-152. https://doi.org/10.31295/ijhms.v3n1.300

Kayser, O., Lemke, A., & Hernandez-Trejo, N. (2005). The impact of nanobiotechnology on the development of new drug delivery systems. Current Pharmaceutical Biotechnology, 6(1), 3–5.

Khalid, A., Khan, R., Ul-Islam, M., Khan, T., & Wahid, F. (2017). Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds. Carbohydrate Polymers, 164, 214–221. https://doi.org/10.1016/j.carbpol.2017.01.061

Kharissova, O. V., Dias, H. V. R., Kharisov, B. I., Pérez, B. O., & Pérez, V. M. J. (2013). The greener synthesis of nanoparticles. Trends in Biotechnology, 31(4), 240–248. https://doi.org/10.1016/j.tibtech.2013.01.003

Khyade, M. S., & Vaikos, N. P. (2009). Pharmacognostical and physio-chemical standardization of leaves of Wrightia tinctoria R. Br. Int J Pharm Res Dev, 8, 1–10.

Korbekandi, H., Iravani, S., & others. (2013). Biological synthesis of nanoparticles using algae. Green Biosynthesis of Nanoparticles: Mechanisms and Applications, 53–60.

Liu, X., Zhang, Z., Jiang, Y., Hu, Y., Wang, Z., Liu, J., Feng, R., Zhang, J., & Huang, G. (2015). Novel PEG-grafted nanostructured lipid carrier for systematic delivery of a poorly soluble anti-leukemia agent Tamibarotene: characterization and evaluation. Drug Delivery, 22(2), 223–229.

Mohanpuria, P., Rana, N. K., & Yadav, S. K. (2008). Biosynthesis of nanoparticles: technological concepts and future applications. Journal of Nanoparticle Research, 10(3), 507–517.

Naveed Ul Haq, A., Nadhman, A., Ullah, I., Mustafa, G., Yasinzai, M., & Khan, I. (2017). Synthesis Approaches of Zinc Oxide Nanoparticles: The Dilemma of Ecotoxicity. Journal of Nanomaterials, 2017, 1–14. https://doi.org/10.1155/2017/8510342

Pandey, R., & Khuller, G. K. (2004). Polymer based drug delivery systems for mycobacterial infections. Current Drug Delivery, 1(3), 195–201.

Raja, A., Ashokkumar, S., Marthandam, R. P., Jayachandiran, J., Khatiwada, C. P., Kaviyarasu, K., Raman, R. G., & Swaminathan, M. (2018). Eco-friendly preparation of zinc oxide nanoparticles using Tabernaemontana divaricata and its photocatalytic and antimicrobial activity. Journal of Photochemistry and Photobiology B: Biology, 181, 53–58.

Sáez, R., Molina, M. A., Ramsey, E. E., Rojo, F., Keenan, E. J., Albanell, J., Lluch, A., Garc’ia-Conde, J., Baselga, J., & Clinton, G. M. (2006). p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer. Clinical Cancer Research, 12(2), 424–431.

Santos, K. S., Barbosa, A. M., Freitas, V., Muniz, A. V., Mendonça, M. C., Calhelha, R. C., Ferreira, I. C. F. R., Franceschi, E., Padilha, F. F., Oliveira, M. B. P. P., & others. (2018). Antiproliferative activity of neem leaf extracts obtained by a sequential pressurized liquid extraction. Pharmaceuticals, 11(3), 76.

Schaming, D., & Remita, H. (2015). Nanotechnology: from the ancient time to nowadays. Foundations of Chemistry, 17(3), 187–205. https://doi.org/10.1007/s10698-015-9235-y

Sharma, B. K., Mehta, B. R., Shah, E. V, Chaudhari, V. P., Roy, D. R., & Mondal Roy, S. (2021). Green Synthesis of Triangular ZnO Nanoparticles Using Azadirachta indica Leaf Extract and Its Shape Dependency for Significant Antimicrobial Activity: Joint Experimental and Theoretical Investigation. Journal of Cluster Science, 1–14.

Tiwari, D. K., Behari, J., & Sen, P. (2008). Time and dose-dependent antimicrobial potential of Ag nanoparticles synthesized by top-down approach. Current Science, 647–655.

Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202

Yin L, Z. Z. (2020). Nanoparticles. In: Wagner WR, Sakiama-Elbert S, Zhang G, Yaszemski MJ, editors. Biomaterials Science (Fourth Edition): Academic Press, 453–483.

Yuvakkumar, R., Suresh, J., Saravanakumar, B., Nathanael, A. J., Hong, S. I., & Rajendran, V. (2015). Rambutan peels promoted biomimetic synthesis of bioinspired zinc oxide nanochains for biomedical applications. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 137, 250–258.