Developing the solid lipid nanoparticles of Losartan using the stearic acid and glyceryl monostearate as the carrier matrices

R. Divya; P. N. Remya; N. Damodharan; N. Damodharan

doi:10.53730/ijhs.v6nS6.12755

Authors

Divya R. Department of Pharmaceutics SRM College of Pharmacy SRM Institute of Science and Technology, Kattankulathur, India
Remya P. N.
remyamathavan@gmail.com
Department of Pharmaceutics SRM College of Pharmacy SRM Institute of Science and Technology, Kattankulathur, India
N. Damodharan Department of Pharmaceutics SRM College of Pharmacy SRM Institute of Science and Technology, Kattankulathur, India
N. Damodharan Department of Pharmaceutics SRM College of Pharmacy SRM Institute of Science and Technology, Kattankulathur, India

Keywords:

entrapment efficiency, hot homogenization technique, hypertension, losartan, invitro drug release, scanning electron microscopy (SEM), solid lipid nanoparticles (SLN), ultrasonication technique

Abstract

This research work deals with the design and development of the solid lipid nanoparticles of Losartan to improve solubility of poorly soluble drug. Losartan solid lipid nanoparticles are formed using hot homogenization technique followed by ultrasonication technique. Experiment trend is predicted using the standard calibration curve. The parameters studied are the percent drug release, entrapment efficiency, particle size of SLN and the in-vitro drug release of prepared SLN. The results obtained in this research work clearly indicated that the developed solid lipid nanoparticle delivery system for the highly lipophilic drug, Losartan using stearic acid, glyceryl monostearate as carrier matrices can be used effectively for hypertension.

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