Role of the silymarin on the prolactin gene expression in the pituitary, estrogen and progesterone hormones of western rats during lactation

Doaa Hashim Jawad; Wefak Jbori Albazi; H. B Mahmood

doi:10.53730/ijhs.v6nS5.10219

Authors

Doaa Hashim Jawad Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Kerbala, Karbala, Iraq
Wefak Jbori Albazi Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Kerbala, Karbala, Iraq
Mahmood, H. B
Hussein.mahmmod@uokerbala.edu.iq
Department of Anatomy and Histology, College of Veterinary Medicine, University of Kerbala, Karbala, Iraq

Keywords:

Effects, Silymarin, Prolactin gene Expression

Abstract

Objective: To see how dose of Silymarin aqueous extracts affected prolactin hormone gene expression in pituitary glands and Androgen hormone in serum samples of female experimental rats throughout nursing. Methods: 24 adult healthy, Two sets of pregnant rats were created (12 each group) and treated as follows for ten days postnatal. G 1 were intubated orally distal water serving as control while, G 2 were intubated orally Silymarin (200 mg\kg\day). Results: The findings show that Silymarin had a strong influence on mRNA–PRL expression in pituitary glands, with a rise in Estrogen and a decline in Progesterone levels. Conclusion: The focus of this study mention a new evidence of the role of Silymarin on the prolactin gene expression for increasing the milk production and level of estrogen & progesterone hormones.

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