Role of silymarin on the some serum sex hormones and oxidant\ antioxidant parameters in during Lactation period on female rats
Keywords:
Silymarin, prolactin, estrogen, progesterone, oxidant\ antioxidant, ratsAbstract
Objective: To see how dosage of Silymarin effect on some serum prolactin ,estrogen and progesterone and some oxidant\ antioxidant in serum samples of female experimental rats throughout nursing. Methods: Twenty-four adult healthy, pregnant rats were divided into two groups (12rats/group) and treated as follows for ten days. G 1 were intubated orally distal water serving as control while, G 2 were intubated orally Silymarin (200 mg\kg\day), the following criteria were measured serum prolactin, estrogen, progesterone hormones, GSH, MDA, SOD and CAT. Results: The findings show that Silymarin had a significant increase influence in serum prolactin, estrogen hormone, SOD, CAT, MDA and a significant decrease in Progesterone and GSH. Conclusion: The focus of this study mention a new evidence of the role of Silymarin on the increasing prolactin, estrogen & progesterone hormones hormone and effect on some level of oxidant\ antioxidant.
Downloads
References
Wu, C. H., Huang, S. M., & Yen, G. C. (2011). Silymarin: a novel antioxidant with antiglycation and antiinflammatory properties in vitro and in vivo. Antioxidants & redox signaling, 14(3), 353-366. https://www.liebertpub.com/doi/abs/10.1089/ars.2010.3134
Farmer, C., Lapointe, J., & Palin, M. F. (2014). Effects of the plant extract silymarin on prolactin concentrations, mammary gland development, and oxidative stress in gestating gilts. Journal of animal science, 92(7), 2922-2930 https://academic.oup.com/jas/article-abstract/92/7/2922/4702184.
Starvaggi Cucuzza, L., Motta, M., Miretti, S., Macchi, E., Martignani, E., Accornero, P., & Baratta, M. (2010). Positive effect of silymarin on cell growth and differentiation in bovine and murine mammary cells. Journal of animal physiology and animal nutrition, 94(1), 111-117 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.14390396.2008.00890.x.
Starvaggi Cucuzza, L., Motta, M., Miretti, S., Macchi, E., Martignani, E., Accornero, P., & Baratta, M. (2010). Positive effect of silymarin on cell growth and differentiation in bovine and murine mammary cells. Journal of animal physiology and animal nutrition, 94(1), 111-117 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.14390396.2008.00890.x.
Feng B, Meng R, Huang B, Shen S, Bi Y and Zhu D 2016. Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice. Free Radical Research 50, 314–327
Freeman ME, Kanyicska B, Lerant A and Nagy G: Prolactin: Structure, function, and regulation of secretion. Physiol Rev 80:1523-1631, 2000.https://pubmed.ncbi.nlm.nih.gov/11015620/
Freeman ME, Kanyicska B, Lerant A and Nagy G: Prolactin: Structure, function, and regulation of secretion. Physiol Rev 80:1523-1631, 2000.https://pubmed.ncbi.nlm.nih.gov/11015620/
Freeman ME, Kanyicska B, Lerant A and Nagy G: Prolactin: Structure, function, and regulation of secretion. Physiol Rev 80:1523-1631, 2000.https://pubmed.ncbi.nlm.nih.gov/11015620/
McMurray RW: Estrogen, prolactin, and autoimmunity: Actions and interactions. Int Immunopharmacol 1: 9951008, 2001. https://doi.org/10.1016/j.otc.2015.09.002
Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev (1998) 19:225–68. doi:10.1210/ edrv.19.3.0334
Starvaggi Cucuzza, L., Motta, M., Miretti, S., Macchi, E., Martignani, E., Accornero, P., & Baratta, M. (2010). Positive effect of silymarin on cell growth and differentiation in bovine and murine mammary cells. Journal of animal physiology and animal nutrition, 94(1), 111-117 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.14390396.2008.00890.x.
Knoppert DC, Page A, Warren J, Seabrook JA, Carr M, Angelini M, et al. The Effect of Two Different domperidone Doses on Maternal Milk Production. J Hum Lact 2013; 29:38-44. https://doi.org/10.1177/0890334412438961
Akinloye AK, Oke BO. Sex Hormonal Pattern of the Female African Giant Rat (Cricetomys gambianus, Waterhouse) at Different Stages of the Oestrous Cycle. Nigerian Veterinary Journal 2012; 33:586-91. https://www.ajol.info/index.php/nvj/article/view/86458
Sriranga, K. R., Singh, A. K., Harini, K. R., Kumar, A., Mukherjee, I., Durge, A. B., & Mohanta, K. P. (2021). Insights of herbal supplements during transition period in dairy animals: An updated review. Iranian Journal of Applied Animal Science, 11(3), 419-429. Doi.org/20.1001.1.2251628.2021.11.3.1.7.
Adewale, O. O., Oduyemi, O. I., & Ayokunle, O. (2014). Oral administration of leaf extracts of Momordica charantia affect reproductive hormones of adult female Wistar rats. Asian Pacific Journal of Tropical Biomedicine, 4, S521-S524. https://doi.org/10.12980/APJTB.4.2014C939.
Santoso, P., Adrianta, K. A., & Wiranatha, I. G. (2021). Phytochemical screening and in vivo test of dewandaru (Eugenia uniflora L) fruit extract on mice exposed to cigarette smoke. International Journal of Health & Medical Sciences, 4(2), 246-252. https://doi.org/10.31295/ijhms.v4n2.1722
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Mohammad, B. I., Alzamely, H., Al Gharrawi, F., & Al-Aubaidy, H. A. (2019). Milk Thistle Seed Extract Favorably Affects Lactation and Development of Mammary Gland in Female Rats. Egyptian Journal of Veterinary Sciences, 50(1), 27-36
17- Daniel EE, Hamman WO, Olorunshola KV, Malgwi IS. The study of effect of aqueous Cucurbita pepo linn seed extract on serum prolactin level of lactating female albinorats. Scientific Journal of Medical Science 2013; 2:6-11. https://iranjournals.nlai.ir/handle/123456789/774136.
Kinn Rød, A. M., Harkestad, N., Jellestad, F. K., & Murison, R. (2017). Comparison of commercial ELISA assays for quantification of corticosterone in serum. Scientific Reports, 7(1), 1-5. https://www.nature.com/articles/s41598-017-06006-4.
Peinnequin, A., Mouret, C., Birot, O., Alonso, A., Mathieu, J., Clarençon, D., ... & Multon, E. (2004). Rat proinflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green. BMC immunology, 5(1), 1-10. Doi.org/10.1186/1471-2172-5-3
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
