Characterization evaluation of chitosan loaded transdermal film of Benincasa Hispida (Thunb.) Cogn. for the treatment of arthritis
Keywords:
Benincasa hispida (Thunb.) Cogn., formulation, anti-arthritic activityAbstract
Hence, in the present study, the plant of Benincasa hispida (Thunb.) Cogn. have been selected for anti-arthritic activity in rats. The films can be made with a constant drug content and little batch variability using the method used. Spectrophotometric analysis at 260 nm was used to determine drug concentration. Drug concentration ranges from 2.37 mg/cm2 to 2.48 mg/cm2 across all formulations, suggesting reasonable consistency. The surface morphology of the film was analyzed by scanning electron microscopy, and the results validated the film's smooth, glossy, and aesthetically attractive look. An indicator of Benincasa hispida's anti-arthritic activity at doses of 200&400 mg/kg, po, is paw swelling. Increasing SA content resulted in a larger film viscosity (measuring between 392.13 and 403.45 Cp).
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References
Edelson SB, Mitchell D. What Your Doctor May Not Tell You About (TM): Autoimmune Disorders: The Revolutionary Drug-free Treatments for Thyroid Disease, Lupus, MS, IBD, Chronic Fatigue, Rheumatoid Arthritis, and Other Diseases. Hachette UK; 2003 Mar 1.
Franzen S, Lommel SA. Targeting cancer with ‘smart bombs’: equipping plant virus nanoparticles for a ‘seek and destroy’mission. Nanomedicine. 2009 Jul;4(5):575-88.
Kuettner KE. Biochemistry of articular cartilage in health and disease. Clinical biochemistry. 1992 Jun 1;25(3):155-63.
Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best practice & research Clinical rheumatology. 2017 Feb 1;31(1):3-18.
Sailaja AK. An overall review on rheumatoid arthritis. Journal of Current Pharma Research. 2014;4(2):1138.
Wahid A, Sridhar BK, Shivakumar S. Preparation and evaluation of transdermal drug delivery system of etoricoxib using modified chitosan. Indian Journal of Pharmaceutical Sciences. 2008 Jul;70(4):455.
Jeong JH, Back SK, An JH, Lee NS, Kim DK, Na CS, Jeong YG, Han SY. Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2019 Oct;107(7):2325-34.
Subramanian K, Indumathi S, Vijayakumar V. Fabrication and evaluation of chitosan-gelatin composite film as a drug carrier for in vitro transdermal delivery. International Journal of Pharmaceutical Sciences and Research. 2014 Feb 1;5(2):438.
Airth JM, Bray DF, Radecka C. Variability of uniformity of weight test as an indicator of the amount of active ingredient in tablets. Journal of Pharmaceutical Sciences. 1967 Feb 1;56(2):233-5.
Wang B, Fu X, Song S, Chu HO, Gibson D, Li C, Shi Y, Wu Z. Simulation and optimization of film thickness uniformity in physical vapor deposition. Coatings. 2018 Sep 16;8(9):325.
Shaieb MD, Singer DI. Tensile strengths of various suture techniques. Journal of Hand Surgery. 1997 Dec;22(6):764-7.
Briassoulis D, Aristopoulou A, Bonora M, Verlodt I. Degradation characterisation of agricultural low-density polyethylene films. Biosystems engineering. 2004 Jun 1;88(2):131-43.
Takeuchi Y, Ikeda N, Tahara K, Takeuchi H. Mechanical characteristics of orally disintegrating films: Comparison of folding endurance and tensile properties. International Journal of Pharmaceutics. 2020 Nov 15;589:119876.
Breazeale EL, McGeorge WT, Breazeale JF. Moisture absorption by plants from an atmosphere of high humidity. Plant Physiology. 1950 Jul;25(3):413.
Papa J, Cain C, Messer HH. Moisture content of vital vs endodontically treated teeth. Dental Traumatology. 1994 Apr;10(2):91-3.
Budhian A, Siegel SJ, Winey KI. Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content. International journal of pharmaceutics. 2007 May 24;336(2):367-75.
Leamy HJ. Charge collection scanning electron microscopy. Journal of Applied Physics. 1982 Jun;53(6):R51-80.
Aqil M, Ali A, Sultana Y, Najmi AK. Fabrication and evaluation of polymeric films for transdermal delivery of pinacidil. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2004 Aug 1;59(8):631-5.
Rinartha, K., & Suryasa, W. (2017). Comparative study for better result on query suggestion of article searching with MySQL pattern matching and Jaccard similarity. In 2017 5th International Conference on Cyber and IT Service Management (CITSM) (pp. 1-4). IEEE.
Rinartha, K., Suryasa, W., & Kartika, L. G. S. (2018). Comparative Analysis of String Similarity on Dynamic Query Suggestions. In 2018 Electrical Power, Electronics, Communications, Controls and Informatics Seminar (EECCIS) (pp. 399-404). IEEE.
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