Evaluate the biomarkers of bone turnover in patients with in sickle cell anemia in Basra province
Keywords:
sickle cell anemia, biomarkers, boneAbstract
Background: Sickle cell anemia (SCD) is one of many haemoglobinopathic disorders which is probably the most common known hereditary blood disorder. In this disease, the homozygous state in which the sickle gene is inherited from the father and the mother, and patients with sickle cell disorders often suffer from chronic hemolytic anemia, which causes bone marrow hyperplasia too. The present study was designed to evaluate the biomarkers which related with the bone turnover in sickle cell anemia patients. Patients with SCA (n=120) 60 males and 60 females were on follow up in the Basra center for Hereditary Blood Disease, who were included in this study and age and sex matched healthy persons (n=60) as controls. biomarkers had important role in many biological processes. Aims: of this study to measure serum levels of different biomarkers such as; BCTx, BSAP, CRP, DPD, IGF-1, OT, TRACP-5b, FER, IGFBPT, Intact (iPTH), Ostase, PINP and serum Ca+. Using Kruskal-Wallis test as statistical test, markers in sickle cell anemia and control groups.The results: showed no significant difference of both male and female patients (HbSS, HbSC and sickle- β-Thalassemia) in compared to control group.
Downloads
References
Ataga KI, Brittain JE, Desai P, May R, Jones S, Delaney J, et al. (2012) Association of coagulation activation with clinical complications in sicklecell disease. PLoS ONE.;7(1):e29786:1-7.
Ballas, S. K (2001). Sickle cell disease: current clinical management. Seminars in Hematology, 2001. Elsevier, 307-314.
Benenson, I. an-d Porter, S. (2018) ‗Sickle Cell Disease: Bone, Joint, Muscle, and Motor Complications‘, Orthopaedic Nursing, 37(4), pp. 221–227. doi: 10.1097/NOR.0000000000000464.
Broucek, J. (2021). Action of High Temperatures on the Biochemical Parameters of Cows. Zivocisna Vyroba
Ceglie G, Di Mauro M, Tarissi De Jacobis I, et al. (2019). Gender-Related Differences in Sickle Cell Disease in a Pediatric Cohort: A Single-Center Retrospective Study. front Mol Biosci. 6:140.
Da Guarda CC, Yahouédéhou S.(2020), Santiago RP, et al. Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC). PLoS One.15(1). 0228399 .
DAVID, H., BRIDGMAN, S., SC DAVIES, A. H. & EMERY, R.( 1993). The shoulder in sickle-cell disease. The Journal of Bone and Joint Surgery 75-B, No. 4.
Fakunle E, Eteng,KI, Shokunbi,WA.( 2012) .D- dimer levels in patients with sickle cell disease during bone pain crises and in the steady state. Pathology and aboratory Medicine International;4:21-25.
HOFFBRAND, A. V., VYAS, P., CAMPO, E., HAFERLACH, T. & GOMEZ, K.( 2019). Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease, John Wiley & Sons. Blackwell, 1-485.
Kalpatthi R, Novelli EM. (2018) Measuring success: utility of biomarkers in sickle cell disease clinical trials and care. Hematology Am Soc Hematol Educ Program. (1):482-492.
Lahhob, Q. R., Mohammed, N. Y., & Abbas, H. J. (2021b). Study of Some Minerals and Trace Elements Levels in patients with Sickle Cell Anemia and Sickle Cell Anemiathalassemia in South of Iraq. Biochemical and Cellular Archives, 21(1), 1091–1095.
Leonard, A. et al. (2021) ‗Curative therapy for hemoglobinopathies: an International Society for Cell & Gene Therapy Stem Cell Engineering Committee review comparing outcomes, accessibility and cost of ex vivo stem cell gene therapy versus allogeneic hematopoietic stem cell transpl‘, Cytotherapy.
Narkhova, A. G. (2021). Biochemical parameters of canned mountain ASH. AGRO-industrial technologies of the central RUSSIA, 2, 17–24.
PLATT, O. S., BRAMBILLA, D. J., ROSSE, W. F., MILNER, P. F., CASTRO, O., STEINBERG, M. H. & KLUG, P. P.( 1994). Mortality in sickle cell disease--life expectancy and risk factors for early death. New England Journal of Medicine, 330, 1639-1644.
Ravikanth , R. , Abraham , M. J. , & Alapati , A. ( 2017 ). Musculoskeletal manifestations in sickle cell anemia Medical Journal of Dr. DY Patil Vidyapeeth , 10 ( 5 ), 453 .
Romero Z, Urbinati F, Geiger S, Cooper AR, Wherley J, Kaufman ML, et al. ( 2013). Beta- globin gene transfer to human bone marrow for sickle cell disease. The Journal of clinical investigation, 123, 3317-3330.
Saud WH, Hassan MK, Al- Salait SK.( 2017). Coagulation activation in patients with sickle cell disease in Basra, Iraq. J Appl Hematol;8:54-60.
Schleicher, J. et al. (2020) ‗Statistical matching for conservation science‘, Conservation Biology, 34(3), pp. 538–549. doi: 10.1111/cobi.13448.
SHI, X., LI, C., LIANG, B., HE, K. & LI, X.( 2014). Weak cation magnetic separation technology and MALDI-TOF-MS in screening serum protein markers in primary type I osteoporosis. Genet Mol Res, 14, 15285-15294.
Tsitsikas, D.A.; Vize, J.; Abukar, J.( 2020) Fat Embolism Syndrome in Sickle Cell Disease. J. Clin. Med., 9, 3601.
Udezue E, Girshab AM. (2004). Differences between males and females in adult sickle cell pain crisis in eastern Saudi Arabia. Ann Saudi Med. 24(3):179-182. FanestilVichaka , Van Siclen Carleen. (2015). Differentiation Between Sickle Cell Anemia and S/β0 Thalassemia. Laboratory Medicine. 46(3). 79-81.
Eaton, W. A. (2020) ‗Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling‘s Science paper‘, American Journal of Hematology, 95(2), pp. 205–211Widana, I.K., Dewi, G.A.O.C., Suryasa, W. (2020). Ergonomics approach to improve student concentration on learning process of professional ethics. Journal of Advanced Research in Dynamical and Control Systems, 12(7), 429-445.
Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202
Yuriah, S., Kartini, F., & Isnaeni, Y. (2022). Experiences of women with preeclampsia. International Journal of Health & Medical Sciences, 5(3), 201-210. https://doi.org/10.21744/ijhms.v5n3.1901
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
