Preparation and pre-formulation estimation method of floating microsphere of ofloxacin

Pravin G. Dhone; P. K. Sinha; Jitendra Mehta; Annapurna Sahoo

doi:10.53730/ijhs.v6nS6.10589

Preparation and pre-formulation estimation method of floating microsphere of ofloxacin

https://doi.org/10.53730/ijhs.v6nS6.10589

Authors

Pravin G. Dhone Professor & Head, Department of Pharmacology, RSDKS GMC, Ambikapur
P. K. Sinha Associate professor Department of skin and VD (Dermatology), RSDKS GMC, Ambikapur
Jitendra Mehta Assistance Professor, Department of Pharmacology, RSDKS GMC, Ambikapur
Annapurna Sahoo MD Pharmacology, District Head Quarter Hospital, Bargarh, Odisha Corresponding Author

Keywords:

Ofloxacin, Microsphere, CDDS

Abstract

Floating drug delivery systems are mainly expected to remain buoyant in gastric contents and consequently to enhance the bioavailability of drugs Microsphere is loaded with a drug in their outer polymer shells was prepared by a novel emulsion-solvent diffusion method. It is floated continuously over the surface of acidic dissolution media containing the surfactant for invitro time 12 hours. Floating microspheres of ofloxacin were prepared by novel o/w emulsion solvent evaporation technique using Ethyl cellulose polymers order to retain drug in body for longer period of time. Ofloxacin has short half-life of 9 hrs. So we prepared a microsphere for increasing their activity.

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Published

12-07-2022

How to Cite

Dhone, P. G., Sinha, P. K., Mehta, J., & Sahoo, A. (2022). Preparation and pre-formulation estimation method of floating microsphere of ofloxacin. International Journal of Health Sciences, 6(S6), 1230–1237. https://doi.org/10.53730/ijhs.v6nS6.10589

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Issue

Vol. 6 No. S6 (2022)

Section

Peer Review Articles

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