Preparation and pre-formulation estimation method of floating microsphere of ofloxacin
Keywords:
Ofloxacin, Microsphere, CDDSAbstract
Floating drug delivery systems are mainly expected to remain buoyant in gastric contents and consequently to enhance the bioavailability of drugs Microsphere is loaded with a drug in their outer polymer shells was prepared by a novel emulsion-solvent diffusion method. It is floated continuously over the surface of acidic dissolution media containing the surfactant for invitro time 12 hours. Floating microspheres of ofloxacin were prepared by novel o/w emulsion solvent evaporation technique using Ethyl cellulose polymers order to retain drug in body for longer period of time. Ofloxacin has short half-life of 9 hrs. So we prepared a microsphere for increasing their activity.
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