Cerebellar tuberculoma in an immunocompetent patient
A case report and literature review
Keywords:
cerebellar tuberculoma, CNS tuberculosis, disseminated tuberculosis, extrapulmonary tuberculosisAbstract
Background: Tuberculosis infection of the Central Nervous System is the major cause of death and morbidity in developing countries. The clinical manifestations and radiological findings in tuberculoma are nonspecific. This article reports a rare case of cerebellar tuberculoma with the manifestation related to an intracranial mass and without the typical clinical symptoms of Tuberculosis in an immunocompetent patient. Case Report: A 20-year-old female with seizure, headache, and vertigo. A mass in the posterior fossa was revealed by Magnetic Resonance Imaging. Thorax scan results showed the Tuberculosis process. The patient then underwent surgery. Histopathological examination displayed chronic granulomatous inflammation and the presence of Acid-Fast Bacilli. The patient received anti-tuberculous drug treatment for one year and anti-seizure medication. Discussion: Cerebellar tuberculoma can resemble an intracranial tumor or cranial abscess. Diagnosis is based on clinical, radiological manifestations, and histopathological analysis. Surgical intervention still has a role in the treatment of this disease. The finding of Mycobacterium tuberculosis on histopathological examination is the gold standard in diagnosing Tuberculosis. Conclusions: Although it is rare, the involvement of Tuberculosis in the CNS should be taken into account in both immunocompetent and immunocompromised patients with neurological symptoms who are living in an endemic area.
Downloads
References
A, B. (2015) ‘Cerebellar Tuberculoma In A Hiv Coinfected Patient With Arnold-Chiari I Malformation’, Journal Of Hiv And Aids ( Issn 2380-5536 ), 1(1), Pp. 2014–2016. Doi: 10.16966/2380-5536.104.
Agrawal, P. Et Al. (2020) ‘Giant Cerebral Tuberculoma Masquerading As Malignant Brain Tumor – A Report Of Two Cases’, Cureus, 12(9). Doi: 10.7759/Cureus.10546.
Bernaerts, A. Et Al. (2003) ‘Tuberculosis Of The Central Nervous System: Overview Of Neuroradiological Findings’, European Radiology, 13(8), Pp. 1876–1890. Doi: 10.1007/S00330-002-1608-7.
Binesh, F., Zahir, S. T. And Bovanlu, T. R. (2013) ‘Isolated Cerebellar Tuberculoma Mimicking Posterior Cranial Fossa Tumour’, Bmj Case Rep, Pp. 1–4. Doi: 10.1136/Bcr-2013-009965.
Bouali, S. Et Al. (2020) ‘Giant Posterior Fossa Tuberculoma In Immunocompetent Adults’, Human Pathology: Case Reports, 19(August 2019), P. 200342. Doi: 10.1016/J.Ehpc.2019.200342.
Capone, S. Et Al. (2021) ‘Presentation, Diagnosis, And Treatment Of A Cerebellar Tuberculoma: Illustrative Case’, Journal Of Neurosurgery: Case Lessons, 2(18), Pp. 2–5. Doi: 10.3171/Case21170.
Chaulagain, D. (2019) ‘Symptoms ,, Diagnosis And Surgical Procedures Of Tuberculoma Of Brain Among Infants- A Systematic Review’, 9(June), Pp. 345–357.
Chen, F. Et Al. (2018) ‘Intracisternal Tuberculoma: A Refractory Type Of Tuberculoma Indicating Surgical Intervention’, Bmc Neurology, 18(1), P. 10. Doi: 10.1186/S12883-017-0996-X.
Davis, A., Meintjes, G. And Wilkinson, R. J. (2018) ‘Treatment Of Tuberculous Meningitis And Its Complications In Adults’, Current Treatment Options In Neurology, 20(3). Doi: 10.1007/S11940-018-0490-9.
Er, M. Et Al. (2018) ‘A Rare Case Of Cerebellar And Lung Tuberculosis Coexistence Which Presenting Intracranial Mass Symptoms’, Eastern Journal Of Medicine, 23(1), Pp. 36–39. Doi: 10.5505/Ejm.2018.36035.
Fabrizio, P. Et Al. (2017) ‘Cognitive Age And Usability Of Health Website Among Older Adults’, Journal Of Neurosurgery Research And Reviews, 1(1), Pp. 1–5. Doi: 10.36959/363/404.
Gasparetto, E. L., Tazoniero, P. And Neto, A. De C. (2003) ‘Disseminated Tuberculosis In A Pregnant Woman Presenting With Numerous Brain Tuberculomas: Case Report’, Arquivos De Neuro-Psiquiatria, 61(3 B), Pp. 855–858. Doi: 10.1590/S0004-282x2003000500028.
Gupta, Shivani Et Al. (2022) ‘Abducens Nerve Palsy : A Sole Presentation Of Isolated Cerebellar Tuberculoma’, Pp. 205–208. Doi: 10.4103/Jdrntruhs.Jdrntruhs.
Ikbal, M. And Sugianto, P. (2022) ‘Perbaikan Klinis Dan Radiologis Tuberkuloma Serebral Dengan Terapi Non Operatif: Dua Laporan Kasus’, Aksona, 1(1), Pp. 18–23. Doi: 10.20473/Aksona.V1i1.96.
Imran, D. Et Al. (2019) ‘Barriers To Diagnosis And Management Of Cns Infections In Indonesia’, American Academy Of Neurology, 92(2), Pp. 104–106. Doi: 10.1212/Wnl.0000000000006732.
Işik, U. Et Al. (2009) ‘Seizures As The Sole Manifestation Of Cerebellar Lesions In Three Children’, Journal Of Pediatric Neurology, 7(2), Pp. 193–198. Doi: 10.3233/Jpn-2009-0286.
Israr Khan, D. Et Al. (2019) ‘Chronic Headache: The Only Manifestation Of Cerebellar Tuberculoma’, Biosciences, Biotechnology Research Asia, 16(04), Pp. 711–714. Doi: 10.13005/Bbra/2786.
Leonard, J. M. (2021) ‘Tuberculosis Of The Central Nervous System’, In Aminoff’s Neurology And General Medicine. Elsevier, Pp. 717–726. Doi: 10.1016/B978-0-12-819306-8.00040-X.
Marais, S. Et Al. (2019) ‘Management Of Intracranial Tuberculous Mass Lesions: How Long Should We Treat For?’, Wellcome Open Research, 4(158), P. 158. Doi: 10.12688/Wellcomeopenres.15501.1.
Nabiuni, M. And Sarvarian, S. (2011) ‘Primary Cerebellar Tuberculoma In Arnold-Chiari Malformation Mimicking Posterior Cranial Fossa Tumor: The First Report’, Global Spine Journal, 1(1), Pp. 019–021. Doi: 10.1055/S-0031-1296052.
Nicolls, D. J. Et Al. (2005) ‘Intracranial Tuberculomas Developing While On Therapy For Pulmonary Tuberculosis’, The Lancet Infectious Diseases, 5(12), Pp. 795–801. Doi: 10.1016/S1473-3099(05)70299-1.
Rock, R. B. Et Al. (2008) ‘Central Nervous System Tuberculosis: Pathogenesis And Clinical Aspects’, Clinical Microbiology Reviews, 21(2), Pp. 243–261. Doi: 10.1128/Cmr.00042-07.
Soni, R. (2021) ‘A Case Of Rarest Presentation Of Cns Tuberculosis As Disseminated Miliary Tuberculoma Brain’. Doi: Doi: Https://Doi.Org/10.21203/Rs.3.Rs-523117/V1 License:
Sutantoyo, F. F. And Sugianto, P. (2022) ‘A Malignant Disseminated Tuberculosis: Concurrent Intracranial Tuberculosis With Skipped Multilevel Spondylitis In A Young Immunocompetent Patient’, Romanian Journal Of Neurology, 21(February), Pp. 83–89. Doi: 10.37897/Rjn.2022.1.16.
Thwaites, G. Et Al. (2009) ‘British Infection Society Guidelines For The Diagnosis And Treatment Of Tuberculosis Of The Central Nervous System In Adults And Children’, Journal Of Infection, 59(3), Pp. 167–187. Doi: 10.1016/J.Jinf.2009.06.011.
Wakisaka, S., Soejima, T. And Matsuoka, S. (1987) ‘Cerebellar Tuberculoma’, Neurologia Medico-Chirurgica, 27(1), Pp. 31–36. Doi: 10.2176/Nmc.27.31.
Weidauer, S. Et Al. (2020) ‘Cns Infections In Immunoincompetent Patients’, Clinical Neuroradiology, 30(1), Pp. 9–25. Doi: 10.1007/S00062-019-00837-6.
Wibawani, R. Et Al. (2019) ‘Head Computed Tomography Images Of Hiv/Aids Patients With Suspected Cerebral Toxoplasmosis In Dr. Soetomo General Hospital Surabaya’, Biomolecular And Health Science Journal, 2(1), P. 21. Doi: 10.20473/Bhsj.V2i1.13343.
Zahrou, F. Et Al. (2019) ‘Diagnosis And Management Of Intracranial Tuberculomas: About 2 Cases And A Review Of The Literature’, Pan African Medical Journal, 34, Pp. 1–6. Doi: Doi:10.11604/Pamj.2019.34.23.17587.
Parmin, P., Suarayasa, K., & Wandira, B. A. (2020). Relationship between quality of service with patient loyality at general polyclinic of kamonji public health center. International Journal of Health & Medical Sciences, 3(1), 86-91. https://doi.org/10.31295/ijhms.v3n1.157
Rinartha, K., Suryasa, W., & Kartika, L. G. S. (2018). Comparative Analysis of String Similarity on Dynamic Query Suggestions. In 2018 Electrical Power, Electronics, Communications, Controls and Informatics Seminar (EECCIS) (pp. 399-404). IEEE.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
