Microemulsion
A futuristic drug delivery approach
Keywords:
microemulsions, bicontinuous phase, lipophilic, sonication, cosurfactants, interfacial tension, dispersed phaseAbstract
Microemulsions are the advanced form of the conventionally used emulsions, which is a biphasic dosage form consisting of two immiscible liquids that are brought together with the application of surfactants and cosurfactants. The micron sized globules of microemulsions helps in achieving targeted action with improved availability and stability. The studies related to the microemulsions concluded its potential in delivering various hydrophilic and lipophilic drugs and several leading manufacturers are considering this as ideal formulation for delivering several potent drugs via several routes including oral, ocular, parenteral, topical routes. The advancements occurred during the previous few years in the pharmaceutical sector results in identification of innovative methods for preparing microemulsions and various patents related to the preparation of microemulsions are granted during last decade. This article enlisted the basic information related to the microemulsion along with its component, structure, method of preparation and evaluation parameters. The applications of microemulsion in several sectors of healthcare segment are also discussed in this review and the future scenario is also discussed in the article. Along with this, the article also enlisted the commercially available microemulsion, patent insight of microemulsion and the list of drugs previously used by the researchers for preparing microemulsion based products.
Downloads
References
Abolmaali, S. S., Tamaddon, A. M., Farvadi, F. S., Daneshamuz, S., & Moghimi, H. (2011). Pharmaceutical nanoemulsions and their potential topical and transdermal applications.
Acharya, D. P., & Hartley, P. G. (2012). Progress in microemulsion characterization. Current Opinion in Colloid & Interface Science, 17(5), 274-280.
Acosta-Zara, E. J., & Yuan, S. (2018). Linker-based lecithin microemulsion delivery vehicles: Google Patents.
Aggarwal, N., Goindi, S., & Khurana, R. (2013). Formulation, characterization and evaluation of an optimized microemulsion formulation of griseofulvin for topical application. Colloids and Surfaces B: Biointerfaces, 105, 158-166.
Ali, S. A., Couillet, I., England, K. W., & Samuel, M. M. (2011). Microemulsion to improve shale gas production by controlling water imbibition: Google Patents.
Ansel, H. C., Popovich, N. G., & AllenJr, L. V. (2020). Pharmaceutical dosage forms and drug delivery systems.
Bajpai, M., Sharma, P., & Mittal, A. (2014). A study of oleic acid oily base for the tropical delivery of dexamethasone microemulsion formulations. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm, 3(3).
Bhatia, G., Zhou, Y., & Banga, A. K. (2013). Adapalene microemulsion for transfollicular drug delivery. Journal of pharmaceutical sciences, 102(8), 2622-2631.
Bordi, F., Cametti, C., Sennato, S., & Diociaiuti, M. (2006). Direct evidence of multicompartment aggregates in polyelectrolyte-charged liposome complexes. Biophysical journal, 91(4), 1513-1520.
Brime, B., Moreno, M. A., Frutos, G., Ballesteros, M. P., & Frutos, P. (2002). Amphotericin B in oil–water lecithin-based microemulsions: formulation and toxicity evaluation. Journal of pharmaceutical sciences, 91(4), 1178-1185.
Brock, M., Hanning, T., Koberstein, E.-M., & Napierala, H. (2006). Microemulsion containing anti-uv filters and/or anti-dandruff agents: Google Patents.
Butani, D., Yewale, C., & Misra, A. (2014). Amphotericin B topical microemulsion: formulation, characterization and evaluation. Colloids and Surfaces B: Biointerfaces, 116, 351-358.
Cai, W., Deng, W., Yang, H., Chen, X., & Jin, F. (2012). A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics. International journal of pharmaceutics, 436(1-2), 536-544.
ČERPNJAK, K., Zvonar, A., Gašperlin, M., & Vrečer, F. (2013). Lipid-based systems as promising approach for enhancing the bioavailability of poorly water-soluble drugs. Acta pharmaceutica, 63(4), 427-445.
Collins-Gold, L., Lyons, R., & Bartholow, L. (1990). Parenteral emulsions for drug delivery. Advanced Drug Delivery Reviews, 5(3), 189-208.
Constantinides, P. P., Scalart, J.-P., Lancaster, C., Marcello, J., Marks, G., Ellens, H., et al. (1994). Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharmaceutical research, 11(10), 1385-1390.
Constantinides, P. P., Welzel, G., Ellens, H., Smith, P. L., Sturgis, S., Yiv, S. H., et al. (1996). Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. Pharmaceutical research, 13(2), 210-215.
Danielsson, I. (1981). The definition of microemulsion.
Derle, D., Sagar, B., & Pimpale, S. (2006). Microemulsion as a vehicle for transdermal permeation of nimesulide. Indian Journal of Pharmaceutical Sciences, 68(5).
Dorman, D. C., Brenneman, K. A., McElveen, A. M., Lynch, S. E., Roberts, K. C., & Wong, B. A. (2002). Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain. Journal of Toxicology and Environmental Health, Part A, 65(20), 1493-1511.
Dreher, F., Walde, P., Walther, P., & Wehrli, E. (1997). Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport. Journal of controlled release, 45(2), 131-140.
Egito, E., Amaral-Machado, L., Alencar, E., & Oliveira, A. (2021). Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery. Drug Delivery and Translational Research, 11(5), 2108-2133.
Ganta, S., Talekar, M., Singh, A., Coleman, T. P., & Amiji, M. M. (2014). Nanoemulsions in translational research—opportunities and challenges in targeted cancer therapy. Aaps Pharmscitech, 15(3), 694-708.
Gasco, M. (1997). Microemulsions in the pharmaceutical field: perspectives and applications. Surfactant science series, 66, 97-122.
Gasco, M. R., Gallarate, M., Trotta, M., Bauchiero, L., Gremmo, E., & Chiappero, O. (1989). Microemulsions as topical delivery vehicles: ocular administration of timolol. Journal of pharmaceutical and biomedical analysis, 7(4), 433-439.
Ge, S., Lin, Y., Lu, H., Li, Q., He, J., Chen, B., et al. (2014). Percutaneous delivery of econazole using microemulsion as vehicle: formulation, evaluation and vesicle-skin interaction. International journal of pharmaceutics, 465(1-2), 120-131.
Ghosh, P. K., Majithiya, R. J., Umrethia, M. L., & Murthy, R. S. (2006). Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability. AAPS pharmscitech, 7(3), E172-E177.
Ghosh, P., & Murthy, R. (2006). Microemulsions: a potential drug delivery system. Current drug delivery, 3(2), 167-180.
Ghosh, V., Mukherjee, A., & Chandrasekaran, N. (2012). Mustard oil microemulsion formulation and evaluation of bactericidal activity. Int J Pharm Pharm Sci, 4(4), 497-500.
Gibaud, S., & Attivi, D. (2012). Microemulsions for oral administration and their therapeutic applications. Expert opinion on drug delivery, 9(8), 937-951.
Goindi, S., Arora, P., Kumar, N., & Puri, A. (2014). Development of novel ionic liquid-based microemulsion formulation for dermal delivery of 5-fluorouracil. AAPS PharmSciTech, 15(4), 810-821.
Goswami, P., Choudhury, A., & Dey, B. K. (2019). Microemulsion–A Potential Carrier for Improved Bioavailability. International Journal of Pharmaceutical & Biological Archive.
Harrison, J., & Zwinderman, M. (2011). Microemulsion cleaning composition: Google Patents.
Haβe, A., & Keipert, S. (1997). Development and characterization of microemulsions for ocular application. European journal of pharmaceutics and biopharmaceutics, 43(2), 179-183.
Ho, H. O., Huang, M. C., Chen, L. C., Hsia, A., Chen, K. T., Chiang, H.-S., et al. (1998). The percutaneous delivery of prostaglandin E1 and its alkyl esters by microemulsions. Chinese Pharmaceutical Journal, 50(5), 257-266.
Ho, H.-O., Hsiao, C.-C., & Sheu, M.-T. (1996). Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs. Journal of pharmaceutical sciences, 85(2), 138-143.
Hoar, T., & Schulman, J. (1943). Transparent water-in-oil dispersions: the oleopathic hydro-micelle. Nature, 152(3847), 102-103.
Jadhav, K., Shetye, S., & Kadam, V. (2010). Design and evaluation of microemulsion based drug delivery system. International journal of Advances in pharmaceutical Sciences, 1(2).
Jha, S. K., Dey, S., & Karki, S. (2011). Microemulsions-potential carrier for improved drug delivery. Asian Journal of Biomedical and Pharmaceutical Sciences, 1(1).
Kakkar Thukral, D., Dumoga, S., & K Mishra, A. (2014). Solid lipid nanoparticles: promising therapeutic nanocarriers for drug delivery. Current drug delivery, 11(6), 771-791.
Kantaria, S., Rees, G. D., & Lawrence, M. J. (2003). Formulation of electrically conducting microemulsion-based organogels. International journal of pharmaceutics, 250(1), 65-83.
Kawakami, K., Yoshikawa, T., Moroto, Y., Kanaoka, E., Takahashi, K., Nishihara, Y., et al. (2002). Microemulsion formulation for enhanced absorption of poorly soluble drugs: I. Prescription design. Journal of Controlled Release, 81(1-2), 65-74.
Khidoyatova, M. R., Kayumov, U. K., Inoyatova, F. K., Fozilov, K. G., Khamidullaeva, G. A., & Eshpulatov, A. S. (2022). Clinical status of patients with coronary artery disease post COVID-19. International Journal of Health & Medical Sciences, 5(1), 137-144. https://doi.org/10.21744/ijhms.v5n1.1858
Komesvarakul, N., Faller, J., Jones, B., Schiltz, J., Szekeres, E., Mentlik, A., et al. (2006). Alcohol-free microemulsion composition: Google Patents.
Kovalik, M., Thoday, K. L., Eatwell, K., & van den Broek, A. H. (2012). Successful treatment of idiopathic sebaceous adenitis in a lionhead rabbit. Journal of exotic pet medicine, 21(4), 336-342.
Kovarik, J. M., Mueller, E. A., Kutz, K., Van Bree, J. B., & Tetzloff, W. (1994). Reduced inter-and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation. Journal of pharmaceutical sciences, 83(3), 444-446.
Kumar, K. S., Dhachinamoorthi, D., Saravanan, R., Gopal, U., & Shanmugam, V. (2011). Microemulsions as carrier for novel drug delivery: a review. Int. J. Pharm. Sci. Rev. Res, 10, 37-45.
Kumar, P., & Mittal, K. (1999b). Handbook of Microemulsions. Science and Technology, 1, 411-523.
Kumar, P., & Mittal, K. L. (1999a). Handbook of microemulsion science and technology: CRC press.
Kumar, R., & Sinha, V. (2014). Preparation and optimization of voriconazole microemulsion for ocular delivery. Colloids and Surfaces B: Biointerfaces, 117, 82-88.
Larm, M. G., Harding, R., Johnston, M., Abram, A. Z., Vijayakumar, P., & Sun, P. (2013a). Microemulsion process and composition: Google Patents.
Larm, M. G., Harding, R., Johnston, M., Abram, A. Z., Vijayakumar, P., & Sun, P. (2013b). Microemulsion and sub-micron emulsion process and compositions: Google Patents.
Lawrence, M. J., & Rees, G. D. (2000). Microemulsion-based media as novel drug delivery systems. Advanced drug delivery reviews, 45(1), 89-121.
Lee, J., Lee, Y., Kim, J., Yoon, M., & Choi, Y. W. (2005). Formulation of microemulsion systems for transdermal delivery of aceclofenac. Archives of pharmacal research, 28(9), 1097-1102.
Levine, D. H., Ghoroghchian, P. P., Freudenberg, J., Zhang, G., Therien, M. J., Greene, M. I., et al. (2008). Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. Methods, 46(1), 25-32.
Li, G., Fan, Y., Li, X., Wang, X., Li, Y., Liu, Y., et al. (2012). In vitro and in vivo evaluation of a simple microemulsion formulation for propofol. International journal of pharmaceutics, 425(1-2), 53-61.
Lu, X., Howard, M. D., Mazik, M., Eldridge, J., Rinehart, J. J., Jay, M., et al. (2008). Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants: optimization and in vitro characterization. The AAPS journal, 10(1), 133-140.
Lucero, M., Vigo, J., & Leon, M. (1994). A study of shear and compression deformations on hydrophilic gels of tretinoin. International journal of pharmaceutics, 106(2), 125-133.
Luschmann, C., Tessmar, J., Schoeberl, S., Strau, O., Luschmann, K., & Goepferich, A. (2014). Self-assembling colloidal system for the ocular administration of cyclosporine A. Cornea, 33(1), 77-81.
Madhav, S., & Gupta, D. (2011). A review on microemulsion based system. International Journal of Pharmaceutical Sciences and Research, 2(8), 1888.
Malcolmson, C., & Lawrence, M. J. (1995). Three-component non-ionic oil-in-water microemulsions using polyoxyethylene ether surfactants. Colloids and surfaces B: Biointerfaces, 4(2), 97-109.
Matyjaszewski, K., & Min, K. (2012). Atom transfer radical polymerization in microemulsion and true emulsion polymerization processes: Google Patents.
McClements, D. J. (2015). Encapsulation, protection, and release of hydrophilic active components: Potential and limitations of colloidal delivery systems. Advances in colloid and interface science, 219, 27-53.
Mehta, K., & Bhatt, D. (2011). Preparation, optimization and in vitro microbiological efficacy of antifungal microemulsion. International Journal of Pharmaceutical Sciences and Research, 2(9), 2424.
Min, D. I. (1996). Neoral: a microemulsion cyclosporine. Journal of Transplant Coordination, 6(1), 5-8.
Moghimipour, E., Salimi, A., & Eftekhari, S. (2013). Design and characterization of microemulsion systems for naproxen. Advanced pharmaceutical bulletin, 3(1), 63.
Moghimipour, E., Salimi, A., & Leis, F. (2012). Preparation and evaluation of tretinoin microemulsion based on pseudo-ternary phase diagram. Advanced pharmaceutical bulletin, 2(2), 141.
Muzaffar, F., Singh, U., & Chauhan, L. (2013). Review on microemulsion as futuristic drug delivery. Int J Pharm Pharm Sci, 5(3), 39-53.
Nadkar, S., & Lokhande, C. (2010). Current trends in novel drug delivery: An OTC perspective. Pharma Times, 42(4), 17-23.
Narang, A. S., Delmarre, D., & Gao, D. (2007). Stable drug encapsulation in micelles and microemulsions. International journal of pharmaceutics, 345(1-2), 9-25.
Nguyen, D. T. (2017). Microemulsion flowback aid composition and method of using same: Google Patents.
Nour, S. A., Shalaby, S., Afify, N. N., Aal, S. A., & Kamal, M. (2002). Formulationand evaluation of econazole nitrate emulgels. J. Drug Res. Egypt, 24(1-2), 63-71.
Oliveira, M. C. K., & Maldonado, G. G. (2012). Composition of microemulsion and method for advanced recovery of heavy oil: Google Patents.
Panapisal, V., Charoensri, S., & Tantituvanont, A. (2012). Formulation of microemulsion systems for dermal delivery of silymarin. Aaps Pharmscitech, 13(2), 389-399.
Paria, S., & Khilar, K. (2000). A review on experimental studies of surfactant adsorption at the hydrophilic solidâĂŞwater interface. Adv Drug Deliv Rev, 45, 89-121.
Park, K.-M., Lee, M.-K., Hwang, K.-J., & Kim, C.-K. (1999). Phospholipid-based microemulsions of flurbiprofen by the spontaneous emulsification process. International journal of pharmaceutics, 183(2), 145-154.
Patel, A. R., & Vavia, P. R. (2007). Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. The AAPS journal, 9(3), E344-E352.
Patel, D., & Sawant, K. K. (2009). Self micro-emulsifying drug delivery system: formulation development and biopharmaceutical evaluation of lipophilic drugs. Current drug delivery, 6(4), 419-424.
Patel, M. R., Patel, R., Parikh, J., Bhatt, K., & Kundawala, A. (2007). Microemulsions: as novel drug delivery vehicle. Latest Reviews, 5(6).
Patel, R. B., Patel, M. R., Bhatt, K. K., & Patel, B. G. (2013). Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of carbamazepine. Bulletin of Faculty of Pharmacy, Cairo University, 51(2), 243-253.
Paul, B. K., & Moulik, S. P. (2001). Uses and applications of microemulsions. Current science, 990-1001.
Peltola, S., Saarinen-Savolainen, P., Kiesvaara, J., Suhonen, T., & Urtti, A. (2003). Microemulsions for topical delivery of estradiol. International journal of pharmaceutics, 254(2), 99-107.
Petit, J. L. V., GONZALEZ, R. D., & Botello, A. F. (2020). Nanocapsules containing microemulsions: Google Patents.
Praça, F. G., Viegas, J. S. R., Peh, H. Y., Garbin, T. N., Medina, W. S. G., & Bentley, M. V. L. B. (2020). Microemulsion co-delivering vitamin A and vitamin E as a new platform for topical treatment of acute skin inflammation. Materials Science and Engineering: C, 110, 110639.
Quintero, L., Jones, T. A., Clark, D. E., Gabrysch, A. D., Forgiarini, A., & Salager, J.-L. (2012). Single phase microemulsions and in situ microemulsions for cleaning formation damage: Google Patents.
Rasal, A., Mahajan, H., Shaikh, H., & Surana, S. (2010). Development and characterization of nasal mucoadhesive microemulsion of sumatriptan succinate. Indian J Novel Drug Deliv, 2, 103-108.
Rhee, Y.-S., Choi, J.-G., Park, E.-S., & Chi, S.-C. (2001). Transdermal delivery of ketoprofen using microemulsions. International journal of pharmaceutics, 228(1-2), 161-170.
Roux, D., & Coulon, C. (1986). Modelling interactions in microemulsion phases. Journal de Physique, 47(7), 1257-1264.
Sahoo, S., Pani, N. R., & Sahoo, S. K. (2014). Microemulsion based topical hydrogel of sertaconazole: Formulation, characterization and evaluation. Colloids and Surfaces B: Biointerfaces, 120, 193-199.
Sarkhejiya Naimish, A., Nakum Mayur, A., Patel Vipul, P., Atara Samir, A., & Desai Thusarbindu, R. (2000). Emerging trend of microemulsion in formulation and research. International bulletin of drug research, 1(1), 54-83.
Shafiq-un-Nabi, S., Shakeel, F., Talegaonkar, S., Ali, J., Baboota, S., Ahuja, A., et al. (2007). Formulation development and optimization using nanoemulsion technique: a technical note. AAPS pharmscitech, 8(2), E12-E17.
Shaji, J., & Reddy, M. (2004). Microemulsions as drug delivery systems. Pharma times, 36(7), 17-24.
Sharma, B., Sharma, A., Gupta, S., & Bishnoi, M. (2015). Formulation, optimization and evaluation of atorvastatin calcium loaded microemulsion. Pharmaceutics & Drug Delivery Research, 2012.
Sharma, S., Garg, T., Rath, G., & Goyal, A. K. (2015). Development and characterization of fenofibrate micro emulsion based on pseudo-ternary phase diagram. Journal of Colloid Science and Biotechnology, 4(1), 49-56.
Shinoda, K., & Lindman, B. (1987). Organized surfactant systems: microemulsions. Langmuir, 3(2), 135-149.
Shiokawa, T., Hattori, Y., Kawano, K., Ohguchi, Y., Kawakami, H., Toma, K., et al. (2005). Effect of polyethylene glycol linker chain length of folate-linked microemulsions loading aclacinomycin A on targeting ability and antitumor effect in vitro and in vivo. Clinical cancer research, 11(5), 2018-2025.
Singh, S., Vijayakumar, M. R., & Dewangan, H. K. (2018). Lipid based aqueous core nanocapsules (ACNs) for encapsulating hydrophillic vinorelbine bitartrate: preparation, optimization, characterization and in vitro safety assessment for intravenous administration. Current drug delivery, 15(9), 1284-1293.
Sintov, A., & Levy, H. (2010). Pharmaceutical compositions based on a microemulsion: Google Patents.
Strickley, R. G. (2004). Solubilizing excipients in oral and injectable formulations. Pharmaceutical research, 21(2), 201-230.
Strickley, R. G. (2007). Currently marketed oral lipid-based dosage forms: drug products and excipients Oral Lipid-Based Formulations (pp. 23-54): CRC Press.
Sullivan, P. F., Tustin, G. J., Christanti, Y., Kubala, G., Drochon, B., & Hughes, T. L. (2010). Aqueous two-phase emulsion gel systems for zone isolation: Google Patents.
Suryasa, I.W., Sudipa, I.N., Puspani, I.A.M., Netra, I.M. (2019). Translation procedure of happy emotion of english into indonesian in kṛṣṇa text. Journal of Language Teaching and Research, 10(4), 738–746
Talegaonkar, S., Azeem, A., Ahmad, F. J., Khar, R. K., Pathan, S. A., & Khan, Z. I. (2008). Microemulsions: a novel approach to enhanced drug delivery. Recent patents on drug delivery & formulation, 2(3), 238-257.
Tamilvanan, S. (2008). Oil-in-water nanosized emulsions: medical applications. Production and Processes, 1327.
Tang, J.-l., Sun, J., & He, Z.-G. (2007). Self-emulsifying drug delivery systems: strategy for improving oral delivery of poorly soluble drugs. Current drug therapy, 2(1), 85-93.
Tenjarla, S. (1999). Microemulsions: an overview and pharmaceutical applications. Critical Reviews™ in Therapeutic Drug Carrier Systems, 16(5).
Üstündag-Okur, N., Gökçe, E. H., Eğrilmez, S., Özer, Ö., & Ertan, G. (2014). Novel ofloxacin-loaded microemulsion formulations for ocular delivery. Journal of ocular pharmacology and therapeutics, 30(4), 319-332.
Vandamme, T. F. (2002). Microemulsions as ocular drug delivery systems: recent developments and future challenges. Progress in retinal and eye research, 21(1), 15-34.
Von Corswant, C., Thorén, P., & Engström, S. (1998). Triglyceride-based microemulsion for intravenous administration of sparingly soluble substances. Journal of pharmaceutical sciences, 87(2), 200-208.
Vyas, S. P., & Khar, R. K. (2004). Targeted & controlled drug delivery: novel carrier systems: CBS publishers & distributors.
Watnasirichaikul, S., Davies, N. M., Rades, T., & Tucker, I. G. (2000). Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions. Pharmaceutical research, 17(6), 684-689.
Wermeling, D. P. H., Miller, J. L., Archer, S. M., Manaligod, J. M., & Rudy, A. C. (2001). Bioavailability and pharmacokinetics of lorazepam after intranasal, intravenous, and intramuscular administration. The Journal of Clinical Pharmacology, 41(11), 1225-1231.
Yaqoob Khan, A., Talegaonkar, S., Iqbal, Z., Jalees Ahmed, F., & Krishan Khar, R. (2006). Multiple emulsions: an overview. Current drug delivery, 3(4), 429-443.
Yiv, S., Li, M., D'cruz, O., & Uckun, F. M. (2006). Gel-microemulsion formulations: Google Patents.
Yuan, Y., Li, S.-m., Mo, F.-k., & Zhong, D.-f. (2006). Investigation of microemulsion system for transdermal delivery of meloxicam. International journal of Pharmaceutics, 321(1-2), 117-123.
Yukuyama, M., Ghisleni, D., Pinto, T., & Bou‐Chacra, N. (2016). Nanoemulsion: process selection and application in cosmetics–a review. International journal of cosmetic science, 38(1), 13-24.
Zhang, Y., & Feng, Y. (2020). Stimuli-responsive microemulsions: State-of-the-art and future prospects. Current Opinion in Colloid & Interface Science, 49, 27-41.
Zhu, W., Yu, A., Wang, W., Dong, R., Wu, J., & Zhai, G. (2008). Formulation design of microemulsion for dermal delivery of penciclovir. International journal of pharmaceutics, 360(1-2), 184-190.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.








