Buccal drug delivery system: A new hope for high drug bioavailability

Alka Sharma; Sushma Verma; Suhail Khan; Syed Akhlaque Ahmed

doi:10.53730/ijhs.v6nS5.9456

Authors

Alka Sharma Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Institutional Area, Greater Noida (UP) -201306
Sushma Verma
SUSHMAVERMA76@GMAIL.COM
Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Institutional Area, Greater Noida (UP) -201306
Suhail Khan Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Institutional Area, Greater Noida (UP) -201306
Syed Akhlaque Ahmed Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Institutional Area, Greater Noida (UP) -201306

Keywords:

Mouth-to-mouth drug delivery systems, mucoadhesive patches for the mouth, mechanisms of the buccal mucosa a description of the patches, composition Analyze of the buccal patch

Abstract

It is well known that certain medications suffer hepatic first-pass metabolism or deteriorate in the digestive system, the buccal drug delivery method may be an alternative to oral administration. Because it is painless and may be swiftly and readily removed if the treatment must be terminated or interrupted, the buccal mucosa has long been ideal for administering medications. This paper focuses on the buccal drug delivery system had the goal of gathering recent literature and presenting a concise explanation of buccal patches by discussing the characteristics of an ideal mucoadhesive system, benefits of buccal delivery and disadvantages thereof, factors affecting buccal absorption, and various types of patches as well as the preparation method and composition thereof. The compilation of the data is also enhanced by adding market products as well as the patented, so that reader will get the complete knowledge about the buccal drug delivery.

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References

DimasiJA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. Journal of health economics [Internet]. 2003 [cited 2019 Apr 30];22(2):151–85. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12606142

Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci. 1998 Jan 1;1(1):15-30.

Hoogstraate JAJ, Wertz PW, Wertz PW. Drug delivery via the buccal mucosa. Pharmaceutical Science & Technology Today. 1998 Oct;1(7):309–16.

Smart J. The basics and underlying mechanisms of mucoadhesion. Advanced Drug Delivery Reviews. 2005 Nov 3;57(11):1556–68.

Verma S, Kaul M, Rawat A, Saini S. An overview on buccal drug delivery system. International journal of pharmaceutical sciences and research. 2011 Jun 1;2(6):1303.

BernkopschnurchA. Mucoadhesive polymers: strategies, achievements and future challenges. Advanced Drug Delivery Reviews [Internet]. 2005 Nov 3 [cited 2019 Apr 28];57(11):1553–5.

Huang Y, Leobandung W, Foss A, Peppas NA. Molecular aspects of muco- and bioadhesion: Journal of Controlled Release. 2000 Mar;65(1-2):63–71.

Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery--a promising option for orally less efficient drugs. Journal of Controlled Release: Official Journal of the Controlled Release Society [Internet]. 2006 Aug 10 [cited 2021 Jan 23];114(1):15–40. Available from: https://pubmed.ncbi.nlm.nih.gov/16828915/

Lee JW, Park JH, Robinson JR. Bioadhesive‐based dosage forms: The next generation. Journal of Pharmaceutical Sciences. 2000 Jul;89(7):850–66.

Mujoriya R, Dhamande K, Wankhede U, Angure S. A review on study of buccal drug delivery system. Inn Syst Design Eng. 2011;2(3):1-3.

Vyas SP, Khar RK. Controlled drug delivery concepts and advances. VallabhPrakashan. 2002;1:411-7.

Nicolazzo JA, Finnin BC. In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa. Drug Absorption Studies. :89–111.

Junginger HE, Hoogstraate JA, Verhoef jcoos. Recent advances in buccal drug delivery and absorption — in vitro and in vivo studies. Journal of Controlled Release. 1999 Nov;62(1-2):149–59.

Fiebrig I, Harding SE, Rowe AJ, Hyman SC, Davis SS. Transmission electron microscopy studies on pig gastric mucin and its interactions with chitosan. Carbohydrate Polymers. 1995 Nov;28(3):239–44.

Shaikh R, Raj Singh TR, Garland MJ, Woolfson AD, Donnelly RF. Mucoadhesive drug delivery systems. Journal of Pharmacy and Bioallied Sciences [Internet]. 2011 [cited 2020 May 31];3(1):89–100. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/

Perioli L, Ambrogi V, Rubini D, Giovagnoli S, Ricci M, Blasi P, et al. Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease. Journal of Controlled Release. 2004 Mar;95(3):521–33.1.

Kaur N. A review on study of buccal patches: current status of formulation and evaluation methods. Journal of Drug Delivery and Therapeutics. 2014 May 15;4(3):69-79.

Tauras JA, Chaloupka FJ. The demand for nicotine replacement therapies. Nicotine & tobacco research. 2003 Jan 1;5(2):237-43.

Nafee NA, Boraie MA, Ismail FA, Mortada LM. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Acta Pharmaceutica (Zagreb, Croatia). 2003 Sep 1;53(3):199-212.

Lee J, Kellaway IW. Peptide Washout and Permeability from Glyceryl Monooleate Buccal Delivery Systems. Drug Development and Industrial Pharmacy. 2002 Jan;28(9):1155–62.

Roy S, Prabhakar B. Bioadhesive polymeric platforms for transmucosal drug delivery systems – a review. Tropical Journal of Pharmaceutical Research [Internet]. 2010 Mar 1 [cited 2021 Jan 23];9(1). Available from: http://www.bioline.org.br/pdf?Pr10012

Kumar TP, Desai KG, Shivakumar HG. Mechanism of buccal permeation enhancers. Indian journal of pharmaceutical education. 2002;36(3):147-51.

Hao J, Heng PWS. Buccal Delivery Systems. Drug Development and Industrial Pharmacy. 2003 Jan;29(8):821–32.

Perioli L, Ambrogi V, Giovagnoli S, Ricci M, Blasi P, Rossi C. Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen. AAPS pharmscitech. 2007 Sep;8(3):E20–7.

Madgulkar A, Kadam S, Pokharkar V. Studies on Formulation Development of Mucoadhesive Sustained Release Itraconazole Tablet Using Response Surface Methodology. AAPS pharmscitech. 2008 Sep;9(3).

Madgulkar A, Kadam S, Pokharkar V. Development of buccal adhesive tablet with prolonged antifungal activity: Optimization andex vivodeposition studies. Indian Journal of Pharmaceutical Sciences. 2009;71(3):290.

Anlar Ş, Çapan Y, Güven O, Göğüş A, Dalkara T, Hincal A. Formulation and in vitro–in vivo evaluation of buccoadhesive morphine sulfate tablets. Pharmaceutical research. 1994 Feb;11(2):231-6.

Giunchedi P, Juliano C, Gavini E, Cossu M, Sorrenti M. Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. European Journal of Pharmaceutics and Biopharmaceutics. 2002 Mar;53(2):233–239.

Budhrani AB, Shadija AK. Mucoadhesive Buccal Drug Delivery System: A Review. American Journal of pharmtechResearch. 2020 Apr 7;10(2):274–85.

Cui Z, Mumper RJ. Buccal transmucosal delivery of calcitonin in rabbits using thin-film composites. Pharmaceutical research. 2002 Dec;19(12):1901-6.

Panda S. Formulation and Evaluation by Appling 32 (Three Squire) Factorial Design of Lercanidipine Hydrochloride Buccal Tablets with Mucoadhesive Polymers. Indian Journal of Pharmaceutical Education and Research. 2020 Mar 3;54(2):367–75.

Park CR, Munday DL. Development and evaluation of a biphasic buccal adhesive tablet for nicotine replacement therapy. International Journal of Pharmaceutics. 2002 Apr;237(1-2):215–26.

Hassan N, Khar RK, Ali M, Ali J. Development and Evaluation of Buccal Bioadhesive Tablet of an Anti-emetic Agent Ondansetron. AAPS pharmscitech. 2009 Sep 9;10(4).

Varshosaz J, Dehghan Z. Development and characterization of buccoadhesive nifedipine tablets. European Journal of Pharmaceutics and Biopharmaceutics. 2002 Sep;54(2):135–41.

Sweet NaskarSk, Kuotsu K. Drug Delivery Based On Buccal Adhesive Systems-A Review. Int J Pharm Bio Sci. 2013; 4(3):240-56.

Shidhaye SS, Thakkar PV, Dand NM, Kadam VJ. Buccal Drug Delivery of Pravastatin Sodium. AAPS pharmscitech. 2010 Mar;11(1):416–24.

Mohammadi-Samani S, Bahri-Najafi R, Yousefi G. Formulation and in vitro evaluation of prednisolone buccoadhesive tablets. Il Farmaco. 2005 Apr;60(4):339–44.

SurajkumarBhaskarao Rathod, Nilesh PrakashraoTekade, Nitin ShridharaoBhajipale, Dhirendra BabjiSanghai. Rospective designing and types of buccal drug delivery system: The Review. GSC Biological and Pharmaceutical Sciences. 2020 Sep 30;12(3):174–9.

Arya RK, Garud A, Jain NK, Garud N. Development and evaluation of mucoadhesive buccal tablets of salbutamol sulfate. Int J Pharmacy Pharm Sci. 2010;2(Suppl 2):40-2.

Shivanand K, Raju SA, Jaykar B. Mucoadhessivebilayered buccal tablets of tizanidine hydrochloride. Int J Pharm Tech Res. 2010 Jul;2(3):1861-9.

Cilurzo F, Minghetti P, Casiraghi A, Montanari L. Characterization of nifedipine solid dispersions. International Journal of Pharmaceutics. 2002 Aug;242(1-2):313–7.

Thakur RR, Rathore DS, Narwal S. Orally disintegrating preparations: recent advancement in formulation and technology. Journal of Drug Delivery and Therapeutics. 2012 May 15;2(3).

R S, D S, R G. Review on Mucoadhesive Drug Delivery System with Special Emphasis on Buccal Route: An Important Tool in Designing of Novel Controlled Drug Delivery System for the Effective Delivery of Pharmaceuticals. Journal of Developing Drugs. 2017;06(01).

Asif H, Rao T, Ayesha N, Anjum M, Rahman M. Design and Evaluation of Mucoadhesive Buccal Patches of Venlafaxine. British Journal of Pharmaceutical Research. 2015 Jan 10;6(2):96–106.

Vamshi Vishnu Y, Chandrasekhar K, Ramesh G, Madhusudan Rao Y. Development of Mucoadhesive Patches for Buccal Administration of Carvedilol. Current Drug Delivery. 2007 Jan 1;4(1):27–39.

R. Nagaraju, P. Subhash Chandra Bose, G. Ravi, Damineni Saritha, Valluru Ravi. A Review on Current status of Buccal drug delivery system. Research J. Pharm. And Tech 2020; 13(6): 2954-2962. Available on: https://rjptonline.org/abstractview.aspx?PID=2020-13-6-76

Perioli L, Ambrogi V, Angelici F, Ricci M, Giovagnoli S, Capuccella M, et al. Development of mucoadhesive patches for buccal administration of ibuprofen. Journal of Controlled Release [Internet]. 2004 Sep 14 [cited 2022 Apr 17];99(1):73–82. Available from: https://www.sciencedirect.com/science/article/pii/S0168365904002883

Ahmad F, Khar R, Sahni J, Raj S. Design and in vitro characterization of buccoadhesive drug delivery system of insulin. Indian Journal of Pharmaceutical Sciences. 2008;70(1):61.

Gupta S, Das S, Singh A, Ghosh S. A Brief Review on Bucco-adhesive Drug Delivery System. Journal of Drug Delivery and Therapeutics. 2021 Aug 15;11(4-S):231–5.

Wong C, Yuen K, Peh K. Formulation and evaluation of controlled release Eudragit buccal patches. International Journal of Pharmaceutics. 1999 Feb;178(1):11–22.

Mohit, Hussain mds. A brief review on buccal drug delivery system: advantages, limitations, and impact on healthcare system. World Journal of Pharmaceutical Research. 8AD Apr;10(5):558–76.

Paul AD, Samatha P, Manasa S, Munemma R, Supriya D. Modeling the Oral Cavity with Mucoadhesive Drug Delivery Systems - A Potential Alternative to Conventional Therapy. International Journal of Pharmaceutical Sciences and Drug Research. 2017 Nov 20;9(06).

Patel V, Prajapati B, Patel M. Design and characterization of chitosan-containing mucoadhesive buccal patches of propranolol hydrochloride. Acta Pharmaceutica. 2007 Mar 1;57(1):61–72.

Patel R, Poddar S. Development and Characterization of Mucoadhesive Buccal Patches of Salbutamol Sulphate. Current Drug Delivery. 2009 Jan 1;6(1):140–4.

Haju s, yadav s, baig r, sawant g. Buccal film: a novel approach for oral mucosal drug delivery system. Asian Journal of Pharmaceutical and Clinical Research. 2021 Jan 5;27–35.

Aprianto, D. R., Parenrengi, M. A., Utomo, B., Fauzi, A. A., & Subagyo, E. A. (2022). Autograft and implant cranioplasty in pediatric patients. International Journal of Health & Medical Sciences, 5(1), 129-136. https://doi.org/10.21744/ijhms.v5n1.1852

Chun M-K, Kwak B-T, Choi H-K. Preparation of buccal patch composed of carbopol, poloxamer and hydroxypropyl methylcellulose. Archives of Pharmacal Research. 2003 Nov;26(11):973–8.

Srivastava N, Aslam S. Recent Advancements and Patents on Buccal Drug Delivery Systems: A Comprehensive Review. Recent Patents on Nanotechnology. 2021 Jun 9;15.

Boyapally H, Nukala RK, Bhujbal P, Douroumis D. Controlled release from directly compressible theophylline buccal tablets. Colloids and Surfaces B: Biointerfaces. 2010 Jun;77(2):227–33.

Palem CR, Gannu R, Doodipala N, Yamsani VV, Yamsani MR. Transmucosal delivery of domperidone from bilayered buccal patches: In Vitro, Ex Vivo and In Vivo characterization. Archives of Pharmacal Research. 2011 Oct;34(10):1701–10.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949

Tran PHL, Duan W, Tran TTD. Recent developments of nanoparticle-delivered dosage forms for buccal delivery. International Journal of Pharmaceutics. 2019 Nov;571:118697.

Flockhart IR, Cort JH. Desmopressin buccal patch composition [Internet]. [cited 2022 May 12]. Available from: https://patents.google.com/patent/US5298256A/en

Kurkela K, Marvola M, Larma I, Virtanen R, Karlsson M. Transmucosal formulations of levosimendan [Internet]. [cited 2022 May 12]. Available from: https://patents.google.com/patent/WO1999032081A1

Malcovati L. Canker sore patch [Internet]. [cited 2022 May 12]. Available from: https://patents.google.com/patent/US20110160634A1/en

Haley J. Soft, adherent, soluble oral patch [Internet]. Available from: https://patents.google.com/patent/US20030124178A1

Daud as, sapkal np, bondemn. Water soluble pharmaceutical film with enhanced stability [Internet]. [cited 2022 May 12]. Available from: https://patents.google.com/patent/WO2015083181A3/en

Search of: mucoadhesive - List Results - clinicaltrials.gov [Internet]. Clinicaltrials.gov. [cited 2022 May 12]. Available from: https://clinicaltrials.gov/ct2/results?Term=mucoadhesive

Singh A, Kumar Sharma P, Malviya R. Sustained Drug Delivery Using Mucoadhesive Microspheres: The Basic Concept, Preparation Methods and Recent Patents. Recent Patents on Nanomedicine. 2012 Jul 25;2(1):62–77.

Crowley MM, Zhang F, Repka MA, Thumma S, Upadhye SB, Kumar Battu S, et al. Pharmaceutical Applications of Hot-Melt Extrusion: Part I. Drug Development and Industrial Pharmacy. 2007 Jan;33(9):909–26.

Ammanage A, Rodriques P, Kempwade A, Hiremath R. Formulation and evaluation of buccal films of piroxicam co-crystals. Future Journal of Pharmaceutical Sciences. 2020 May 25;6(1).